HPTLC methods to assay active ingredients in pharmaceutical formulations: A review of the method development and validation steps
High-performance thin-layer chromatography (HPTLC) is still increasingly finding its way in pharmaceutical analysis in some parts of the world. With the advancements in the stationary phases and the introduction of densitometers as detection equipment, the technique achieves for given applications a...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2012-07, Vol.66, p.11-23 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 66 |
| creator | Shewiyo, D.H. Kaale, E. Risha, P.G. Dejaegher, B. Smeyers-Verbeke, J. Heyden, Y. Vander |
| description | High-performance thin-layer chromatography (HPTLC) is still increasingly finding its way in pharmaceutical analysis in some parts of the world. With the advancements in the stationary phases and the introduction of densitometers as detection equipment, the technique achieves for given applications a precision and trueness comparable to high-performance liquid chromatography (HPLC). In this review, the literature is surveyed for developed and validated HPTLC methods to assay active ingredients in pharmaceutical formulations published in the period 2005–2011. Procedures and approaches for method development, validation and quantitative assays are compared with the standard ways of conducting them. Applications of HPTLC in some other areas are also briefly highlighted. |
| doi_str_mv | 10.1016/j.jpba.2012.03.034 |
| format | Article |
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Psychology ; General pharmacology ; high performance liquid chromatography ; HPTLC ; Humans ; Medical sciences ; Method development ; Method validation ; Pharmaceutical analysis ; Pharmaceutical formulation ; Pharmaceutical Preparations - analysis ; Pharmaceutical Preparations - chemistry ; Pharmacology. Drug treatments ; thin layer chromatography ; Validation Studies as Topic</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2012-07, Vol.66, p.11-23</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. 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Vander</creatorcontrib><title>HPTLC methods to assay active ingredients in pharmaceutical formulations: A review of the method development and validation steps</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>High-performance thin-layer chromatography (HPTLC) is still increasingly finding its way in pharmaceutical analysis in some parts of the world. With the advancements in the stationary phases and the introduction of densitometers as detection equipment, the technique achieves for given applications a precision and trueness comparable to high-performance liquid chromatography (HPLC). In this review, the literature is surveyed for developed and validated HPTLC methods to assay active ingredients in pharmaceutical formulations published in the period 2005–2011. Procedures and approaches for method development, validation and quantitative assays are compared with the standard ways of conducting them. Applications of HPTLC in some other areas are also briefly highlighted.</description><subject>Active ingredient</subject><subject>active ingredients</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Thin Layer - methods</subject><subject>densitometers</subject><subject>Densitometry</subject><subject>drug formulations</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>high performance liquid chromatography</subject><subject>HPTLC</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Method development</subject><subject>Method validation</subject><subject>Pharmaceutical analysis</subject><subject>Pharmaceutical formulation</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmacology. 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| ispartof | Journal of pharmaceutical and biomedical analysis, 2012-07, Vol.66, p.11-23 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Active ingredient active ingredients Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid - methods Chromatography, Thin Layer - methods densitometers Densitometry drug formulations Fundamental and applied biological sciences. Psychology General pharmacology high performance liquid chromatography HPTLC Humans Medical sciences Method development Method validation Pharmaceutical analysis Pharmaceutical formulation Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments thin layer chromatography Validation Studies as Topic |
| title | HPTLC methods to assay active ingredients in pharmaceutical formulations: A review of the method development and validation steps |
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