Positive allosteric modulation of α4β2 nAChR agonist induced behaviour

Abstract Neuronal cholinergic transmission is a prerequisite for proper CNS function. Consequently, disturbance of this system is associated with a number of pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, schizophrenia and ADHD. Consequently, drug discovery...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2012-06, Vol.1458, p.67-75
Hauptverfasser:	Rode, F, Munro, G, Holst, D, Nielsen, E.Ø, Troelsen, K.B, Timmermann, D.B, Rønn, L.C.B, Grunnet, M
Format:	Artikel
Sprache:	eng
Schlagworte:	6-OHDA model Acute pain agonists Allosteric Regulation - drug effects Allosteric Regulation - physiology Alzheimer disease analgesics animal behavior Animals Azepines - pharmacology Behavioral psychophysiology Biological and medical sciences brain cholinergic receptors Corpus Striatum - drug effects Corpus Striatum - physiology dopamine Female formalin Fundamental and applied biological sciences. Psychology in vitro studies ion channels Male Neurology Neurotransmission and behavior Nicotinic Agonists - pharmacology Oxadiazoles - pharmacology Oxidopamine - toxicity pain Pain - chemically induced Pain - physiopathology Pain Measurement - drug effects Pain Measurement - methods Parkinson disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - physiopathology Partial agonist Positive allosteric modulation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyridines - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Receptors, Nicotinic - physiology Rotation stoichiometry Striatal dopamine release α4β2 nAChR
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!