Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers, and metastasis is the principal cause of death in ESCC patients. It has been shown that amplification and overexpression of mitotic serine/threonine kinase Aurora-A occur in several types of human tumors, including ESCC...

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Veröffentlicht in:	Molecular cancer research 2012-05, Vol.10 (5), p.588-596
Hauptverfasser:	Wang, Xiaoxia, Lu, Na, Niu, Bo, Chen, Xianjiu, Xie, Jun, Cheng, Niuliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurora Kinases Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement - genetics Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasm Invasiveness - genetics Oncogene Protein v-akt - metabolism Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Small Interfering
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