RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility

The factors responsible for cardiomyopathy are not fully understood. Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart develo...

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Veröffentlicht in:	Cardiovascular research 2012-06, Vol.94 (3), p.418-427
Hauptverfasser:	Poon, Kar Lai, Tan, Kar Tong, Wei, Yang Ye, Ng, Chee Peng, Colman, Alan, Korzh, Vladimir, Xu, Xiu Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques Heart - embryology Humans Myocardial Contraction Myocytes, Cardiac - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sarcomeres - metabolism Zebrafish - anatomy & histology Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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