Effects of hypoxia and HIFs on cancer metabolism

Cancer cells are characterized by rapid proliferation and require adaptive metabolic responses to allow continued biosynthesis and cell growth in the setting of decreased oxygen (O 2 ) and nutrient availability. The hypoxia-inducible factors (HIFs) are a common link between adaptation to low O 2 , c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of hematology 2012-05, Vol.95 (5), p.464-470
Hauptverfasser: Mucaj, Vera, Shay, Jessica E. S., Simon, M. Celeste
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cancer cells are characterized by rapid proliferation and require adaptive metabolic responses to allow continued biosynthesis and cell growth in the setting of decreased oxygen (O 2 ) and nutrient availability. The hypoxia-inducible factors (HIFs) are a common link between adaptation to low O 2 , changes in cancer metabolism, and malignant progression. The HIF-α subunits differentially regulate metabolic enzymes and other key factors involved in glycolysis, changes in redox status, and oxidative phosphorylation. Importantly, metabolic changes can, in turn, regulate HIF activity. Finally, changes in metabolism under hypoxia lead to important crosstalk between cancer cells and the stromal compartment of the microenvironment.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-012-1070-5