Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway

Group IVA cytosolic phospholipase A(2) (cPLA(2)α), which preferentially cleaves arachidonic acid from phospholipids, plays a role in apoptosis and tissue injury. Downstream signals in response to tumor necrosis factor (TNF)-α, a mediator of myocardial ischemia-reperfusion (I/R) injury, involve cPLA(...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2012-05, Vol.302 (10), p.H2018-H2030
Hauptverfasser:	Saito, Yukio, Watanabe, Kazuhiro, Fujioka, Daisuke, Nakamura, Takamitsu, Obata, Jun-ei, Kawabata, Kenichi, Watanabe, Yosuke, Mishina, Hideto, Tamaru, Shun, Kita, Yoshihiro, Shimizu, Takao, Kugiyama, Kiyotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Etanercept Group IV Phospholipases A2 - deficiency Group IV Phospholipases A2 - genetics Group IV Phospholipases A2 - physiology Immunoglobulin G - pharmacology Leukotriene B4 - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Receptors, Tumor Necrosis Factor Signal Transduction - physiology Thromboxane B2 - metabolism Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - prevention & control
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!