Non-invasive measures of tissue autofluorescence are increased in Type 1 diabetes complications and correlate with a non-invasive measure of vascular dysfunction
Diabet. Med. 29, 726–733 (2012) Objective To determine if ocular and skin autofluorescence, reflecting advanced glycation end‐products, and vascular stiffness correlate in non‐diabetic and Type 1 diabetic subjects and if levels differ by diabetes status. Research design and methods Patients with T...
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| creator | Januszewski, A. S. Sachithanandan, N. Karschimkus, C. O'Neal, D. N. Yeung, C. K. Alkatib, N. Jenkins, A. J. |
| description | Diabet. Med. 29, 726–733 (2012)
Objective To determine if ocular and skin autofluorescence, reflecting advanced glycation end‐products, and vascular stiffness correlate in non‐diabetic and Type 1 diabetic subjects and if levels differ by diabetes status.
Research design and methods Patients with Type 1 diabetes (n = 69, 19 with and 50 without vascular complications) and 60 subjects without diabetes (control) had ocular and skin autofluorescence and pulse‐wave analysis performed in the fasted state. Correlations between measures within groups used the Pearson or Spearman correlation‐coefficient and measures between groups were compared by anova.
Results Lens and skin autofluorescence correlated in control (r = 0.58, P = 0.0001) and in Type 1 diabetes (r = 0.53, P = 0.001). Corneal autofluorescence correlated with lens (r = 0.53, r = 0.52, P = 0.0001) and skin autofluorescence (r = 0.34, P = 0.01 and r = 0.49, P = 0.00001) in control and Type 1 diabetes respectively. In Type 1 diabetes, small and large artery elasticity correlated inversely and systemic vascular resistance correlated positively with skin autofluorescence (all P = 0.001), and with lens and corneal autofluorescence (all P |
| doi_str_mv | 10.1111/j.1464-5491.2011.03562.x |
| format | Article |
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Objective To determine if ocular and skin autofluorescence, reflecting advanced glycation end‐products, and vascular stiffness correlate in non‐diabetic and Type 1 diabetic subjects and if levels differ by diabetes status.
Research design and methods Patients with Type 1 diabetes (n = 69, 19 with and 50 without vascular complications) and 60 subjects without diabetes (control) had ocular and skin autofluorescence and pulse‐wave analysis performed in the fasted state. Correlations between measures within groups used the Pearson or Spearman correlation‐coefficient and measures between groups were compared by anova.
Results Lens and skin autofluorescence correlated in control (r = 0.58, P = 0.0001) and in Type 1 diabetes (r = 0.53, P = 0.001). Corneal autofluorescence correlated with lens (r = 0.53, r = 0.52, P = 0.0001) and skin autofluorescence (r = 0.34, P = 0.01 and r = 0.49, P = 0.00001) in control and Type 1 diabetes respectively. In Type 1 diabetes, small and large artery elasticity correlated inversely and systemic vascular resistance correlated positively with skin autofluorescence (all P = 0.001), and with lens and corneal autofluorescence (all P < 0.03). In Type 1 diabetes tissue advanced glycation end‐products correlated with C‐reactive protein and inversely with the estimated glucose disposal rate and with circulating advanced glycation end‐product levels. Relative to non‐diabetic subjects, lens, corneal and skin fluorescence were increased (all P < 0.001) and small artery elasticity was decreased in diabetes (P = 0.04). Lens, corneal and skin autofluorescence were greater (all P = 0.0001) in patients with Type 1 diabetes with complications compared to those without complications, but small artery elasticity did not differ significantly.
Conclusions Ocular and skin autofluorescence and vascular stiffness correlate in non‐diabetic and Type 1 diabetes subjects and are increased in Type 1 diabetes. Tissue advanced glycation end‐products correlate with vascular risk factors, including circulating advanced glycation end‐products.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2011.03562.x</identifier><identifier>PMID: 22211881</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Pressure ; Body Mass Index ; C-Reactive Protein - metabolism ; Cornea - blood supply ; Cross-Sectional Studies ; diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Angiopathies - blood ; Diabetic Angiopathies - etiology ; Diabetic Angiopathies - physiopathology ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - etiology ; Diabetic Retinopathy - physiopathology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding. Feeding behavior ; Female ; Fluorescence ; Fundamental and applied biological sciences. Psychology ; Glycated Hemoglobin A - metabolism ; glycation ; Glycation End Products, Advanced - blood ; Humans ; Lens, Crystalline - blood supply ; Male ; Medical sciences ; Risk Factors ; Skin - blood supply ; tissue fluorescence ; Vascular Resistance ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>Diabetic medicine, 2012-06, Vol.29 (6), p.726-733</ispartof><rights>2011 The Authors. Diabetic Medicine © 2011 Diabetes UK</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4372-6c59dbd101244e11e35d310ca001ce40ee6e7238025a1495893d0b83f58c4f23</citedby><cites>FETCH-LOGICAL-c4372-6c59dbd101244e11e35d310ca001ce40ee6e7238025a1495893d0b83f58c4f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2011.03562.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2011.03562.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25901335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22211881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Januszewski, A. S.</creatorcontrib><creatorcontrib>Sachithanandan, N.</creatorcontrib><creatorcontrib>Karschimkus, C.</creatorcontrib><creatorcontrib>O'Neal, D. N.</creatorcontrib><creatorcontrib>Yeung, C. K.</creatorcontrib><creatorcontrib>Alkatib, N.</creatorcontrib><creatorcontrib>Jenkins, A. J.</creatorcontrib><title>Non-invasive measures of tissue autofluorescence are increased in Type 1 diabetes complications and correlate with a non-invasive measure of vascular dysfunction</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Diabet. Med. 29, 726–733 (2012)
Objective To determine if ocular and skin autofluorescence, reflecting advanced glycation end‐products, and vascular stiffness correlate in non‐diabetic and Type 1 diabetic subjects and if levels differ by diabetes status.
Research design and methods Patients with Type 1 diabetes (n = 69, 19 with and 50 without vascular complications) and 60 subjects without diabetes (control) had ocular and skin autofluorescence and pulse‐wave analysis performed in the fasted state. Correlations between measures within groups used the Pearson or Spearman correlation‐coefficient and measures between groups were compared by anova.
Results Lens and skin autofluorescence correlated in control (r = 0.58, P = 0.0001) and in Type 1 diabetes (r = 0.53, P = 0.001). Corneal autofluorescence correlated with lens (r = 0.53, r = 0.52, P = 0.0001) and skin autofluorescence (r = 0.34, P = 0.01 and r = 0.49, P = 0.00001) in control and Type 1 diabetes respectively. In Type 1 diabetes, small and large artery elasticity correlated inversely and systemic vascular resistance correlated positively with skin autofluorescence (all P = 0.001), and with lens and corneal autofluorescence (all P < 0.03). In Type 1 diabetes tissue advanced glycation end‐products correlated with C‐reactive protein and inversely with the estimated glucose disposal rate and with circulating advanced glycation end‐product levels. Relative to non‐diabetic subjects, lens, corneal and skin fluorescence were increased (all P < 0.001) and small artery elasticity was decreased in diabetes (P = 0.04). Lens, corneal and skin autofluorescence were greater (all P = 0.0001) in patients with Type 1 diabetes with complications compared to those without complications, but small artery elasticity did not differ significantly.
Conclusions Ocular and skin autofluorescence and vascular stiffness correlate in non‐diabetic and Type 1 diabetes subjects and are increased in Type 1 diabetes. Tissue advanced glycation end‐products correlate with vascular risk factors, including circulating advanced glycation end‐products.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cornea - blood supply</subject><subject>Cross-Sectional Studies</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Angiopathies - blood</subject><subject>Diabetic Angiopathies - etiology</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diabetic Retinopathy - etiology</subject><subject>Diabetic Retinopathy - physiopathology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>glycation</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Humans</subject><subject>Lens, Crystalline - blood supply</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Risk Factors</subject><subject>Skin - blood supply</subject><subject>tissue fluorescence</subject><subject>Vascular Resistance</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhLyBfkLgk-DMfBw5oW1qkUlRpJY6W15kIL4mz2Em7-3P4p0zY7fbCAcuSR-PnnfH4JYRylnNcHzY5V4XKtKp5LhjnOZO6EPnuGVmcLp6TBSuVyCQr-Rl5ldKGMS5qWb8kZ0IIzquKL8jv2yFkPtzb5O-B9mDTFCHRoaWjT2kCaqdxaLtpwKyD4DARgfrgIqLQYERX-y1QThtv1zCi1g39tvPOjn4IidrQYCZG6OwI9MGPP6il4R9N556YcVNnI232qZ2Cm0u8Ji9a2yV4czzPyerz5Wp5nd18u_qy_HSTOSVLkRVO18264TijUsA5SN1IzpzFqR0oBlBAKWTFhLZc1bqqZcPWlWx15VQr5Dl5fyi7jcOvCdJoeo8Td50NMEzJYGHFcTOGaHVAXRxSitCabfS9jXuEzOyP2ZjZBjPbYGZ_zF9_zA6lb49dpnUPzUn4aAgC744AfoXt2miD8-mJ0zXjUmrkPh64B9_B_r8fYC6-Xs4R6rOD3qcRdie9jT9NUcpSm--3V2aprvVddSdQ_Qf-1b0I</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Januszewski, A. S.</creator><creator>Sachithanandan, N.</creator><creator>Karschimkus, C.</creator><creator>O'Neal, D. N.</creator><creator>Yeung, C. K.</creator><creator>Alkatib, N.</creator><creator>Jenkins, A. J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Non-invasive measures of tissue autofluorescence are increased in Type 1 diabetes complications and correlate with a non-invasive measure of vascular dysfunction</title><author>Januszewski, A. S. ; Sachithanandan, N. ; Karschimkus, C. ; O'Neal, D. N. ; Yeung, C. K. ; Alkatib, N. ; Jenkins, A. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4372-6c59dbd101244e11e35d310ca001ce40ee6e7238025a1495893d0b83f58c4f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cornea - blood supply</topic><topic>Cross-Sectional Studies</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Angiopathies - blood</topic><topic>Diabetic Angiopathies - etiology</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diabetic Retinopathy - etiology</topic><topic>Diabetic Retinopathy - physiopathology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>glycation</topic><topic>Glycation End Products, Advanced - blood</topic><topic>Humans</topic><topic>Lens, Crystalline - blood supply</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Risk Factors</topic><topic>Skin - blood supply</topic><topic>tissue fluorescence</topic><topic>Vascular Resistance</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Januszewski, A. S.</creatorcontrib><creatorcontrib>Sachithanandan, N.</creatorcontrib><creatorcontrib>Karschimkus, C.</creatorcontrib><creatorcontrib>O'Neal, D. N.</creatorcontrib><creatorcontrib>Yeung, C. K.</creatorcontrib><creatorcontrib>Alkatib, N.</creatorcontrib><creatorcontrib>Jenkins, A. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Januszewski, A. S.</au><au>Sachithanandan, N.</au><au>Karschimkus, C.</au><au>O'Neal, D. N.</au><au>Yeung, C. K.</au><au>Alkatib, N.</au><au>Jenkins, A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-invasive measures of tissue autofluorescence are increased in Type 1 diabetes complications and correlate with a non-invasive measure of vascular dysfunction</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2012-06</date><risdate>2012</risdate><volume>29</volume><issue>6</issue><spage>726</spage><epage>733</epage><pages>726-733</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Diabet. Med. 29, 726–733 (2012)
Objective To determine if ocular and skin autofluorescence, reflecting advanced glycation end‐products, and vascular stiffness correlate in non‐diabetic and Type 1 diabetic subjects and if levels differ by diabetes status.
Research design and methods Patients with Type 1 diabetes (n = 69, 19 with and 50 without vascular complications) and 60 subjects without diabetes (control) had ocular and skin autofluorescence and pulse‐wave analysis performed in the fasted state. Correlations between measures within groups used the Pearson or Spearman correlation‐coefficient and measures between groups were compared by anova.
Results Lens and skin autofluorescence correlated in control (r = 0.58, P = 0.0001) and in Type 1 diabetes (r = 0.53, P = 0.001). Corneal autofluorescence correlated with lens (r = 0.53, r = 0.52, P = 0.0001) and skin autofluorescence (r = 0.34, P = 0.01 and r = 0.49, P = 0.00001) in control and Type 1 diabetes respectively. In Type 1 diabetes, small and large artery elasticity correlated inversely and systemic vascular resistance correlated positively with skin autofluorescence (all P = 0.001), and with lens and corneal autofluorescence (all P < 0.03). In Type 1 diabetes tissue advanced glycation end‐products correlated with C‐reactive protein and inversely with the estimated glucose disposal rate and with circulating advanced glycation end‐product levels. Relative to non‐diabetic subjects, lens, corneal and skin fluorescence were increased (all P < 0.001) and small artery elasticity was decreased in diabetes (P = 0.04). Lens, corneal and skin autofluorescence were greater (all P = 0.0001) in patients with Type 1 diabetes with complications compared to those without complications, but small artery elasticity did not differ significantly.
Conclusions Ocular and skin autofluorescence and vascular stiffness correlate in non‐diabetic and Type 1 diabetes subjects and are increased in Type 1 diabetes. Tissue advanced glycation end‐products correlate with vascular risk factors, including circulating advanced glycation end‐products.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22211881</pmid><doi>10.1111/j.1464-5491.2011.03562.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood Pressure Body Mass Index C-Reactive Protein - metabolism Cornea - blood supply Cross-Sectional Studies diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Angiopathies - blood Diabetic Angiopathies - etiology Diabetic Angiopathies - physiopathology Diabetic Retinopathy - blood Diabetic Retinopathy - etiology Diabetic Retinopathy - physiopathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Female Fluorescence Fundamental and applied biological sciences. Psychology Glycated Hemoglobin A - metabolism glycation Glycation End Products, Advanced - blood Humans Lens, Crystalline - blood supply Male Medical sciences Risk Factors Skin - blood supply tissue fluorescence Vascular Resistance Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Non-invasive measures of tissue autofluorescence are increased in Type 1 diabetes complications and correlate with a non-invasive measure of vascular dysfunction |
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