Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes

Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplasmic reticulum (SR). Heart-specific overexpression of CSQ in transgenic mi...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2012-05, Vol.302 (10), p.H2008-H2017
Hauptverfasser:	Kučerová, Dana, Baba, Hideo A, Bokník, Peter, Fabritz, Larissa, Heinick, Alexander, Mát'uš, Marek, Müller, Frank U, Neumann, Joachim, Schmitz, Wilhelm, Kirchhefer, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Signaling - physiology Calsequestrin - genetics Calsequestrin - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Disease Models, Animal Fibrosis Heart Failure - metabolism Heart Failure - physiopathology Heart Ventricles - cytology Heart Ventricles - metabolism Heart Ventricles - pathology Mice Mice, Transgenic Muscle Proteins - genetics Muscle Proteins - metabolism Myocardial Contraction - physiology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
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