Suppression of Skeletal Muscle Turnover in Cancer Cachexia: Evidence from the Transcriptome in Sequential Human Muscle Biopsies

The mechanisms underlying muscle wasting in patients with cancer remain poorly understood, and consequently there remains an unmet clinical need for new biomarkers and treatment strategies. Microarrays were used to examine the transcriptome in single biopsies from healthy controls (n = 6) and in pai...

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Veröffentlicht in:	Clinical cancer research 2012-05, Vol.18 (10), p.2817-2827
Hauptverfasser:	GALLAGHER, Lain J, STEPHENS, Nathan A, MACDONALD, Alisdair J, SKIPWORTH, Richard J. E, HUSI, Holger, GREIG, Carolyn A, ROSS, James A, TIMMONS, James A, FEARON, Kenneth C. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Biological and medical sciences C-Reactive Protein - analysis Cachexia - etiology Cachexia - genetics Cachexia - metabolism Cachexia - pathology Female Gastrointestinal Neoplasms - complications Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gene Expression Humans Male Medical sciences Middle Aged Motor Activity Muscle Strength Muscular Atrophy - genetics Muscular Atrophy - metabolism Muscular Atrophy - pathology Pharmacology. Drug treatments Quadriceps Muscle - metabolism Quadriceps Muscle - pathology Serum Albumin - analysis Transcriptome Weight Loss
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