Targeting the lateral but not the third ventricle induces bone loss in ewe: an experimental approach to generate an improved large animal model of osteoporosis

Osteoporosis is a chronic disease characterized by bone loss and increased skeletal fragility. Large animal models are required for preclinical testing of new therapeutic approaches. We have recently demonstrated that continuous intracerebroventricular (ICV) application of leptin into the lateral ve...

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Veröffentlicht in:	The journal of trauma 2012-03, Vol.72 (3), p.720-726
Hauptverfasser:	Oheim, Ralf, Beil, Frank Timo, Barvencik, Florian, Egermann, Marcus, Amling, Michael, Clarke, Iain J, Pogoda, Pia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Autopsy Bone (trabecular) Bone loss Bone strength Bone turnover Brain Brain Diseases - chemically induced Brain Diseases - complications Brain Diseases - diagnosis Cerebrospinal fluid Disease Models, Animal Excretion Female Fibrosis Injections, Intraventricular Lateral Ventricles - abnormalities Lateral Ventricles - drug effects Leptin Leptin - administration & dosage Leptin - toxicity Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Osteoclasts Osteogenesis Osteoporosis Osteoporosis - diagnosis Osteoporosis - etiology Osteoporosis - metabolism Ovariectomy Prognosis Sheep stainless steel Third Ventricle Trauma Ventricles (cerebral)
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