Evaluation of Subclinical Hypothyroidism in Ambulatory Children With Controlled Epilepsy on Valproate Monotherapy
There are conflicting reports in the literature about the influence of valproate on thyroid function. A cross-sectional study was performed to determine the prevalence of subclinical hypothyroidism in ambulatory children aged 3 to 15 years with controlled epilepsy receiving valproate monotherapy for...
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| Veröffentlicht in: | Journal of child neurology 2012-05, Vol.27 (5), p.594-597 |
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| container_title | Journal of child neurology |
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| creator | Sahu, Jitendra K. Gulati, Sheffali Kabra, Madhulika Arya, Ravindra Sharma, Rajni Gupta, Nandita Kaleekal, Thomas Reeta, Kh Gupta, Y. K. |
| description | There are conflicting reports in the literature about the influence of valproate on thyroid function. A cross-sectional study was performed to determine the prevalence of subclinical hypothyroidism in ambulatory children aged 3 to 15 years with controlled epilepsy receiving valproate monotherapy for at least 6 months. Fifty-seven consecutive children with controlled epilepsy on valproate monotherapy and 52 healthy age- and sex-matched control children were studied. Thyroid-stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, and serum valproic acid levels were measured. There was a significantly high (P = .012) prevalence of subclinical hypothyroidism (26%) in those receiving valproate monotherapy compared with healthy controls (7.7%). Median duration of valproate therapy was significantly higher (P = .039) in the subclinical hypothyroidism group (21 months, range 6-36) compared with those without subclinical hypothyroidism (14 months, range 6-25). Results of the present study suggest higher prevalence of subclinical hypothyroidism in children with controlled epilepsy on long-term valproate monotherapy. |
| doi_str_mv | 10.1177/0883073811421985 |
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K.</creator><creatorcontrib>Sahu, Jitendra K. ; Gulati, Sheffali ; Kabra, Madhulika ; Arya, Ravindra ; Sharma, Rajni ; Gupta, Nandita ; Kaleekal, Thomas ; Reeta, Kh ; Gupta, Y. K.</creatorcontrib><description>There are conflicting reports in the literature about the influence of valproate on thyroid function. A cross-sectional study was performed to determine the prevalence of subclinical hypothyroidism in ambulatory children aged 3 to 15 years with controlled epilepsy receiving valproate monotherapy for at least 6 months. Fifty-seven consecutive children with controlled epilepsy on valproate monotherapy and 52 healthy age- and sex-matched control children were studied. Thyroid-stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, and serum valproic acid levels were measured. There was a significantly high (P = .012) prevalence of subclinical hypothyroidism (26%) in those receiving valproate monotherapy compared with healthy controls (7.7%). Median duration of valproate therapy was significantly higher (P = .039) in the subclinical hypothyroidism group (21 months, range 6-36) compared with those without subclinical hypothyroidism (14 months, range 6-25). Results of the present study suggest higher prevalence of subclinical hypothyroidism in children with controlled epilepsy on long-term valproate monotherapy.</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/0883073811421985</identifier><identifier>PMID: 22114214</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Ambulatory Care ; Antibodies ; Antibodies - blood ; Anticonvulsants - adverse effects ; Anticonvulsants - blood ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Electrochemical Techniques ; Epilepsy ; Epilepsy - blood ; Epilepsy - drug therapy ; Female ; Humans ; Hypothyroidism ; Hypothyroidism - blood ; Hypothyroidism - chemically induced ; Hypothyroidism - diagnosis ; Iodide Peroxidase - immunology ; Male ; Peroxidase ; Retrospective Studies ; Statistics, Nonparametric ; Thyroid ; Thyroid-stimulating hormone ; Thyrotropin - blood ; Thyroxine ; Thyroxine - blood ; Time Factors ; Valproic acid ; Valproic Acid - adverse effects ; Valproic Acid - blood</subject><ispartof>Journal of child neurology, 2012-05, Vol.27 (5), p.594-597</ispartof><rights>The Author(s) 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-f9b9e6c7391e505bd1f27342ea748a8da424bd4d00868d079aa897c0ddc1286a3</citedby><cites>FETCH-LOGICAL-c370t-f9b9e6c7391e505bd1f27342ea748a8da424bd4d00868d079aa897c0ddc1286a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0883073811421985$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0883073811421985$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22114214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahu, Jitendra K.</creatorcontrib><creatorcontrib>Gulati, Sheffali</creatorcontrib><creatorcontrib>Kabra, Madhulika</creatorcontrib><creatorcontrib>Arya, Ravindra</creatorcontrib><creatorcontrib>Sharma, Rajni</creatorcontrib><creatorcontrib>Gupta, Nandita</creatorcontrib><creatorcontrib>Kaleekal, Thomas</creatorcontrib><creatorcontrib>Reeta, Kh</creatorcontrib><creatorcontrib>Gupta, Y. K.</creatorcontrib><title>Evaluation of Subclinical Hypothyroidism in Ambulatory Children With Controlled Epilepsy on Valproate Monotherapy</title><title>Journal of child neurology</title><addtitle>J Child Neurol</addtitle><description>There are conflicting reports in the literature about the influence of valproate on thyroid function. A cross-sectional study was performed to determine the prevalence of subclinical hypothyroidism in ambulatory children aged 3 to 15 years with controlled epilepsy receiving valproate monotherapy for at least 6 months. Fifty-seven consecutive children with controlled epilepsy on valproate monotherapy and 52 healthy age- and sex-matched control children were studied. Thyroid-stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, and serum valproic acid levels were measured. There was a significantly high (P = .012) prevalence of subclinical hypothyroidism (26%) in those receiving valproate monotherapy compared with healthy controls (7.7%). Median duration of valproate therapy was significantly higher (P = .039) in the subclinical hypothyroidism group (21 months, range 6-36) compared with those without subclinical hypothyroidism (14 months, range 6-25). Results of the present study suggest higher prevalence of subclinical hypothyroidism in children with controlled epilepsy on long-term valproate monotherapy.</description><subject>Adolescent</subject><subject>Ambulatory Care</subject><subject>Antibodies</subject><subject>Antibodies - blood</subject><subject>Anticonvulsants - adverse effects</subject><subject>Anticonvulsants - blood</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Electrochemical Techniques</subject><subject>Epilepsy</subject><subject>Epilepsy - blood</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - chemically induced</subject><subject>Hypothyroidism - diagnosis</subject><subject>Iodide Peroxidase - immunology</subject><subject>Male</subject><subject>Peroxidase</subject><subject>Retrospective Studies</subject><subject>Statistics, Nonparametric</subject><subject>Thyroid</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine</subject><subject>Thyroxine - blood</subject><subject>Time Factors</subject><subject>Valproic acid</subject><subject>Valproic Acid - adverse effects</subject><subject>Valproic Acid - blood</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1v2zAURYkiQe243TsFHLMo4ZdMajQMpwngIEPSdhSeRKqmQYkKKQXQvy9dOx0KBMjE4Z178PguQt8ouaZUyhuiFCeSK0oFo4XKP6E5lURliil-huaHcXaYz9BFjHtCiMoL8hnNGPubEHP0snkFN8JgfYd9g5_Gqna2szU4fDf1fthNwVttY4tth1dtNToYfJjwemedDqbDv-yww2vfDcE7ZzTe9NaZPk44CX-C64OHweAH3yWXCdBPX9B5Ay6ar6d3gX7cbp7Xd9n28fv9erXNai7JkDVFVZhlLXlBTU7yStOGSS6YASkUKA2CiUoLnf60VJrIAkAVsiZa15SpJfAFujp60wovo4lD2dpYG-egM36MJSVUUEq4zD-CEsaFojyh5IjWwccYTFP2wbYQpgSVh07K_ztJkcuTfaxao_8F3kpIQHYEIvw25d6PoUuHeV_4B5DClLY</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Sahu, Jitendra K.</creator><creator>Gulati, Sheffali</creator><creator>Kabra, Madhulika</creator><creator>Arya, Ravindra</creator><creator>Sharma, Rajni</creator><creator>Gupta, Nandita</creator><creator>Kaleekal, Thomas</creator><creator>Reeta, Kh</creator><creator>Gupta, Y. 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| subjects | Adolescent Ambulatory Care Antibodies Antibodies - blood Anticonvulsants - adverse effects Anticonvulsants - blood Case-Control Studies Child Child, Preschool Children Chromatography, High Pressure Liquid Cross-Sectional Studies Electrochemical Techniques Epilepsy Epilepsy - blood Epilepsy - drug therapy Female Humans Hypothyroidism Hypothyroidism - blood Hypothyroidism - chemically induced Hypothyroidism - diagnosis Iodide Peroxidase - immunology Male Peroxidase Retrospective Studies Statistics, Nonparametric Thyroid Thyroid-stimulating hormone Thyrotropin - blood Thyroxine Thyroxine - blood Time Factors Valproic acid Valproic Acid - adverse effects Valproic Acid - blood |
| title | Evaluation of Subclinical Hypothyroidism in Ambulatory Children With Controlled Epilepsy on Valproate Monotherapy |
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