Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma

Osteosarcoma (OS) severely threatens the health of young people and understanding on the molecular mechanisms of OS etiology enables gene therapy to become an effective therapeutic modality. However, insufficient expression level of genes using existing vectors limits the clinical application of gen...

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Veröffentlicht in:	Molecular and cellular biochemistry 2012-05, Vol.364 (1-2), p.337-344
Hauptverfasser:	Chunbao, Li, Qianpeng, Cheng, Jia, Liu, Bin, Wang, Dongfeng, Chen, Yujie, Liu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses Animals Biochemistry Biomedical and Life Sciences Biosafety Bone cancer Bone Neoplasms - genetics Bone Neoplasms - therapy Cardiology Cell Line, Tumor Development and progression Etiology Expression vectors Fibroblasts - cytology Gene expression Gene therapy Genetic engineering Genetic Therapy - methods Genetic Vectors Green Fluorescent Proteins - genetics Growth Health aspects Humans Infection Life Sciences Medical Biochemistry Mice Mice, Inbred BALB C Molecular biology Molecular modelling Neoplasms, Experimental Oncology Oncolysis Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Osteosarcoma Osteosarcoma - genetics Osteosarcoma - therapy Replication Therapeutic applications TNF-Related Apoptosis-Inducing Ligand - biosynthesis TNF-Related Apoptosis-Inducing Ligand - genetics TRAIL protein Tumors
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