Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer

Purpose Targeted oncolytic adenoviruses capable of replication selectively in cancer cells are an appealing approach for the treatment of various cancer types refractory to conventional therapies. The aim of this study was to evaluate the effect of Ad5/3MDR1E1, a multidrug resistance gene 1 (MDR1)-t...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2012-04, Vol.138 (4), p.603-610
Hauptverfasser:	Rein, Daniel T., Volkmer, Anne, Bauerschmitz, Gerd, Beyer, Ines M., Janni, Wolfgang, Fleisch, Markus C., Welter, Anne Kathrin, Bauerschlag, Dirk, Schöndorf, Thomas, Breidenbach, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - physiology Adenovirus Adenoviruses Animal models Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antitumor agents ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences Cancer Research Capsid Proteins - genetics Cell Line Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cells Chemotherapy Cisplatin - pharmacology Combined Modality Therapy Cytostatic agents Data processing Drug Resistance, Neoplasm Drug therapy Expression vectors Female Female genital diseases Gynecology. Andrology. Obstetrics Hematology hepatotoxicity Humans Internal Medicine Liver Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Multidrug resistance Oncology Oncolysis Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - physiology Original Article Ovarian cancer Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Ovarian Neoplasms - virology P-Glycoprotein Paclitaxel Paclitaxel - pharmacology Pharmacology. Drug treatments Promoter Regions, Genetic - genetics Promoters Replication Survival Analysis Toxicity Treatment Outcome Tumor cells Tumors Virus Replication Xenograft Model Antitumor Assays
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