Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines

Highly active against Botrytis cinerea (grey mould), Mycosphaerella graminicola (wheat leaf blotch) and Alternaria solani (potato and tomato early blight). Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics i...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-05, Vol.20 (9), p.2803-2810
Hauptverfasser:	Lamberth, Clemens, Trah, Stephan, Wendeborn, Sebastian, Dumeunier, Raphael, Courbot, Mikael, Godwin, Jeremy, Schneiter, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternaria solani Animals Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology antifungal properties Ascomycota - drug effects Biological and medical sciences blight Botrytis - drug effects Botrytis cinerea Chlorine Crop protection Early blight fungi Fungicidal activity Fungicide Fungicides gray mold Heterocycle Leaf blotch Lycopersicon esculentum mechanism of action Medical sciences Microtubules Mycosphaerella graminicola Nitrogen Pathogens Pharmacology. Drug treatments plant pathogens polymerization potatoes Promoters Pyridazine pyridazines Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - pharmacology Solanum tuberosum Structure-Activity Relationship Structure-activity relationships Swine tomatoes Triticum aestivum Tubulin Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology wheat
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