Icaritin inhibits T cell activation and prolongs skin allograft survival in mice

Icaritin is a native compound from Epimedium Genus, a traditional Chinese herbal medicine which is effective in treating asthma, autoimmune diseases and viral infections. In the present paper, the immunosuppressive effects of icaritin were found through in vitro and in vivo studies. Icaritin could d...

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Veröffentlicht in:	International immunopharmacology 2012-05, Vol.13 (1), p.1-7
Hauptverfasser:	Li, Xiaojuan, Hu, Yiping, He, Longgang, Wang, Song, Zhou, Hua, Liu, Shuwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma Autoimmune diseases Biological and medical sciences CD25 CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell activation Cell proliferation Cell Proliferation - drug effects Cell survival Concanavalin A Cytokines Dose-Response Relationship, Drug Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - therapeutic use Epimedium Female Flavonoids - administration & dosage Flavonoids - isolation & purification Flavonoids - therapeutic use gamma -Interferon Graft Survival - drug effects Helper cells Herbal medicines Humans Icaritin Immunosuppression Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - therapeutic use Infection Interleukin 2 Interleukin 4 Interleukin-2 - antagonists & inhibitors Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors Jurkat Cells Lymphocyte Activation - drug effects Lymphocytes T Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mitogens NF-AT protein Ovalbumin Pharmacology. Drug treatments Skin Skin Transplantation Spleen - cytology Spleen - drug effects Spleen - immunology Splenocytes T cell activation Th1 Cells - drug effects Th1 Cells - immunology Th1/Th2 cytokines Transplantation, Homologous
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