Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts

Phosphorodiamidate morpholino oligonucleotides (PMOs) have been extensively applied in antisense strategies for gene regulation because of their high stability in serum and low toxicity. However, chain elongation of PMOs requires long reaction time because few efficient methods have been developed f...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-02, Vol.22 (3), p.1445-1447
Hauptverfasser:	Harakawa, Taro, Tsunoda, Hirosuke, Ohkubo, Akihiro, Seio, Kohji, Sekine, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	additives Antisense Biological and medical sciences blood serum bromides Bromides - pharmacology chemistry Chromatography, High Pressure Liquid Elongation Gene regulation genes Inorganic salt catalysis inorganic salts Lithium Lithium Compounds - pharmacology Medical sciences Molecular Structure Morpholino nucleic acid Morpholinos - chemical synthesis Morpholinos - chemistry Oligonucleotides Pharmacology. Drug treatments Phosphorodiamidate bond Salts Salts - chemistry Toxicity
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