Intranasal delivery of biologics to the central nervous system

Treatment of central nervous system (CNS) diseases is very difficult due to the blood–brain barrier's (BBB) ability to severely restrict entry of all but small, non-polar compounds. Intranasal administration is a non-invasive method of drug delivery which may bypass the BBB to allow therapeutic...

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Veröffentlicht in:	Advanced drug delivery reviews 2012-05, Vol.64 (7), p.614-628
Hauptverfasser:	Lochhead, Jeffrey J., Thorne, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Alzheimer's disease Animals Biological Products - administration & dosage Biological Products - metabolism Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Central Nervous System - drug effects Central Nervous System - metabolism Central Nervous System Diseases - drug therapy Central Nervous System Diseases - metabolism Drug delivery Drug Delivery Systems - methods Drug Delivery Systems - trends Gene vectors Humans Nasal passage Olfactory Proteins Stem cells Trigeminal
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