NO CONSISTENT EVIDENCE FOR ASSOCIATION BETWEEN mtDNA VARIANTS AND ALZHEIMER DISEASE

Objective: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. Methods: We tested 138 mtDNA variants for a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2012-04, Vol.78 (15), p.1038-1042
Hauptverfasser:	Hudson, G, Sims, R, Harold, D, Chapman, J, Hollingworth, P, Gerrish, A, Russo, G, Hamshere, M, Moskvina, V, Jones, N, Thomas, C, Stretton, A, Holmans, P A, O'Donovan, M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Data processing Etiology Genetic diversity Geriatrics Mitochondrial DNA Neurodegenerative diseases Nitric oxide Quality control Reviews
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1042
container_issue	15
container_start_page	1038
container_title	Neurology
container_volume	78
creator	Hudson, G Sims, R Harold, D Chapman, J Hollingworth, P Gerrish, A Russo, G Hamshere, M Moskvina, V Jones, N Thomas, C Stretton, A Holmans, P A O'Donovan, M C
description	Objective: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. Methods: We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis. Results: In the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD. Conclusion: The current evidence linking common mtDNA variations with AD is not compelling.
format	Article
fullrecord	<record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1014106002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1014106002</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_10141060023</originalsourceid><addsrcrecordid>eNqVzr0OgjAUQOEOmog_73BHF5JWVHCscAlN9DahDSYuhBhMNCBq4f118AWczvINZ8Q8zleRH0RhNGFT5-6ci80q3HnMkIZYk1HGIlnAQiVIMUKqc5DG6FhJqzTBHu0JkaDtE5JQyFxJsgYkJSAP5wzVEXNIlEFpcM7G16px9eLXGVumaOPMf76711C7vmxv7lI3TfWou8GVgou14NvvYvAH_QD96jtm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1014106002</pqid></control><display><type>article</type><title>NO CONSISTENT EVIDENCE FOR ASSOCIATION BETWEEN mtDNA VARIANTS AND ALZHEIMER DISEASE</title><source>Journals@Ovid Ovid Autoload</source><source>Alma/SFX Local Collection</source><creator>Hudson, G ; Sims, R ; Harold, D ; Chapman, J ; Hollingworth, P ; Gerrish, A ; Russo, G ; Hamshere, M ; Moskvina, V ; Jones, N ; Thomas, C ; Stretton, A ; Holmans, P A ; O'Donovan, M C</creator><creatorcontrib>Hudson, G ; Sims, R ; Harold, D ; Chapman, J ; Hollingworth, P ; Gerrish, A ; Russo, G ; Hamshere, M ; Moskvina, V ; Jones, N ; Thomas, C ; Stretton, A ; Holmans, P A ; O'Donovan, M C</creatorcontrib><description>Objective: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. Methods: We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis. Results: In the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD. Conclusion: The current evidence linking common mtDNA variations with AD is not compelling.</description><identifier>ISSN: 0028-3878</identifier><language>eng</language><subject>Alzheimer's disease ; Data processing ; Etiology ; Genetic diversity ; Geriatrics ; Mitochondrial DNA ; Neurodegenerative diseases ; Nitric oxide ; Quality control ; Reviews</subject><ispartof>Neurology, 2012-04, Vol.78 (15), p.1038-1042</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Hudson, G</creatorcontrib><creatorcontrib>Sims, R</creatorcontrib><creatorcontrib>Harold, D</creatorcontrib><creatorcontrib>Chapman, J</creatorcontrib><creatorcontrib>Hollingworth, P</creatorcontrib><creatorcontrib>Gerrish, A</creatorcontrib><creatorcontrib>Russo, G</creatorcontrib><creatorcontrib>Hamshere, M</creatorcontrib><creatorcontrib>Moskvina, V</creatorcontrib><creatorcontrib>Jones, N</creatorcontrib><creatorcontrib>Thomas, C</creatorcontrib><creatorcontrib>Stretton, A</creatorcontrib><creatorcontrib>Holmans, P A</creatorcontrib><creatorcontrib>O'Donovan, M C</creatorcontrib><title>NO CONSISTENT EVIDENCE FOR ASSOCIATION BETWEEN mtDNA VARIANTS AND ALZHEIMER DISEASE</title><title>Neurology</title><description>Objective: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. Methods: We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis. Results: In the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD. Conclusion: The current evidence linking common mtDNA variations with AD is not compelling.</description><subject>Alzheimer's disease</subject><subject>Data processing</subject><subject>Etiology</subject><subject>Genetic diversity</subject><subject>Geriatrics</subject><subject>Mitochondrial DNA</subject><subject>Neurodegenerative diseases</subject><subject>Nitric oxide</subject><subject>Quality control</subject><subject>Reviews</subject><issn>0028-3878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqVzr0OgjAUQOEOmog_73BHF5JWVHCscAlN9DahDSYuhBhMNCBq4f118AWczvINZ8Q8zleRH0RhNGFT5-6ci80q3HnMkIZYk1HGIlnAQiVIMUKqc5DG6FhJqzTBHu0JkaDtE5JQyFxJsgYkJSAP5wzVEXNIlEFpcM7G16px9eLXGVumaOPMf76711C7vmxv7lI3TfWou8GVgou14NvvYvAH_QD96jtm</recordid><startdate>20120410</startdate><enddate>20120410</enddate><creator>Hudson, G</creator><creator>Sims, R</creator><creator>Harold, D</creator><creator>Chapman, J</creator><creator>Hollingworth, P</creator><creator>Gerrish, A</creator><creator>Russo, G</creator><creator>Hamshere, M</creator><creator>Moskvina, V</creator><creator>Jones, N</creator><creator>Thomas, C</creator><creator>Stretton, A</creator><creator>Holmans, P A</creator><creator>O'Donovan, M C</creator><scope>7TK</scope><scope>7TM</scope></search><sort><creationdate>20120410</creationdate><title>NO CONSISTENT EVIDENCE FOR ASSOCIATION BETWEEN mtDNA VARIANTS AND ALZHEIMER DISEASE</title><author>Hudson, G ; Sims, R ; Harold, D ; Chapman, J ; Hollingworth, P ; Gerrish, A ; Russo, G ; Hamshere, M ; Moskvina, V ; Jones, N ; Thomas, C ; Stretton, A ; Holmans, P A ; O'Donovan, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_10141060023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alzheimer's disease</topic><topic>Data processing</topic><topic>Etiology</topic><topic>Genetic diversity</topic><topic>Geriatrics</topic><topic>Mitochondrial DNA</topic><topic>Neurodegenerative diseases</topic><topic>Nitric oxide</topic><topic>Quality control</topic><topic>Reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudson, G</creatorcontrib><creatorcontrib>Sims, R</creatorcontrib><creatorcontrib>Harold, D</creatorcontrib><creatorcontrib>Chapman, J</creatorcontrib><creatorcontrib>Hollingworth, P</creatorcontrib><creatorcontrib>Gerrish, A</creatorcontrib><creatorcontrib>Russo, G</creatorcontrib><creatorcontrib>Hamshere, M</creatorcontrib><creatorcontrib>Moskvina, V</creatorcontrib><creatorcontrib>Jones, N</creatorcontrib><creatorcontrib>Thomas, C</creatorcontrib><creatorcontrib>Stretton, A</creatorcontrib><creatorcontrib>Holmans, P A</creatorcontrib><creatorcontrib>O'Donovan, M C</creatorcontrib><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudson, G</au><au>Sims, R</au><au>Harold, D</au><au>Chapman, J</au><au>Hollingworth, P</au><au>Gerrish, A</au><au>Russo, G</au><au>Hamshere, M</au><au>Moskvina, V</au><au>Jones, N</au><au>Thomas, C</au><au>Stretton, A</au><au>Holmans, P A</au><au>O'Donovan, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NO CONSISTENT EVIDENCE FOR ASSOCIATION BETWEEN mtDNA VARIANTS AND ALZHEIMER DISEASE</atitle><jtitle>Neurology</jtitle><date>2012-04-10</date><risdate>2012</risdate><volume>78</volume><issue>15</issue><spage>1038</spage><epage>1042</epage><pages>1038-1042</pages><issn>0028-3878</issn><abstract>Objective: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. Methods: We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis. Results: In the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD. Conclusion: The current evidence linking common mtDNA variations with AD is not compelling.</abstract></addata></record>
fulltext	fulltext
identifier	ISSN: 0028-3878
ispartof	Neurology, 2012-04, Vol.78 (15), p.1038-1042
issn	0028-3878
language	eng
recordid	cdi_proquest_miscellaneous_1014106002
source	Journals@Ovid Ovid Autoload; Alma/SFX Local Collection
subjects	Alzheimer's disease Data processing Etiology Genetic diversity Geriatrics Mitochondrial DNA Neurodegenerative diseases Nitric oxide Quality control Reviews
title	NO CONSISTENT EVIDENCE FOR ASSOCIATION BETWEEN mtDNA VARIANTS AND ALZHEIMER DISEASE
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A51%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=NO%20CONSISTENT%20EVIDENCE%20FOR%20ASSOCIATION%20BETWEEN%20mtDNA%20VARIANTS%20AND%20ALZHEIMER%20DISEASE&rft.jtitle=Neurology&rft.au=Hudson,%20G&rft.date=2012-04-10&rft.volume=78&rft.issue=15&rft.spage=1038&rft.epage=1042&rft.pages=1038-1042&rft.issn=0028-3878&rft_id=info:doi/&rft_dat=%3Cproquest%3E1014106002%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1014106002&rft_id=info:pmid/&rfr_iscdi=true