CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12

The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of CALM/AF10 -positive leukemias, and compare...

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Veröffentlicht in:	Leukemia 2012-05, Vol.26 (5), p.1012-1019
Hauptverfasser:	Mulaw, M A, Krause, A J, Deshpande, A J, Krause, L F, Rouhi, A, La Starza, R, Borkhardt, A, Buske, C, Mecucci, C, Ludwig, W-D, Lottaz, C, Bohlander, S K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Acute myeloid leukemia Analysis Angiogenesis Animals Antigens Assembly B-cell lymphoma Biological and medical sciences Bone marrow Cancer Research Care and treatment Cell interactions Chromatin Assembly and Disassembly - genetics Chromatin remodeling Chromosome Fragile Sites Chromosome translocations Chromosomes, Human, Pair 10 Critical Care Medicine Deoxyribonucleic acid DNA DNA methylation DNA repair DNA Repair - genetics Fusion protein Gene expression Gene regulation Genes Genetic aspects Genomics Health aspects Heat shock proteins Hematologic and hematopoietic diseases Hematology Homology Hsp40 protein Humans Intensive Internal Medicine Leukemia Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphoma Medical sciences Medicine Medicine & Public Health Mice Monomeric Clathrin Assembly Proteins - genetics Oncology original-article Physiological aspects Proteins Repair Reverse Transcriptase Polymerase Chain Reaction Risk factors RNA-directed DNA polymerase Transcription Factors - genetics Translocation Translocation, Genetic Transplantation Transplants & implants Up-Regulation
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