CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12
The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of CALM/AF10 -positive leukemias, and compare...
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| creator | Mulaw, M A Krause, A J Deshpande, A J Krause, L F Rouhi, A La Starza, R Borkhardt, A Buske, C Mecucci, C Ludwig, W-D Lottaz, C Bohlander, S K |
| description | The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the
CALM/AF10
fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of
CALM/AF10
-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 normal bone marrow samples. Based on gene set enrichment analyses, the
CALM/AF10
-positive samples showed significant upregulation of genes involved in chromatin assembly and maintenance and DNA repair process, and downregulation of angiogenesis and cell communication genes. Interestingly, we observed a striking upregulation of four genes located immediately centromeric to the break point of the t(10;11)(p12;q14) on 10p12 (
COMMD3
(COMM domain containing 3),
BMI1
(B lymphoma Mo-MLV insertion region 1 homolog),
DNAJC1
(DnaJ (Hsp40) homolog subfamily C member 1) and
SPAG6
(sperm associated antigen 6)). We also conducted semiquantitative reverse transcriptase-PCR analysis on leukemic blasts from a murine
CALM/AF10
transplantation model that does not have the translocation.
Commd3
,
Bmi1
and
Dnajc1
, but not
Spag6
were upregulated in these samples. These results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the
CALM/AF10
fusion gene expression, though the mechanism of regulation is not well understood. |
| doi_str_mv | 10.1038/leu.2011.307 |
| format | Article |
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CALM/AF10
fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of
CALM/AF10
-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 normal bone marrow samples. Based on gene set enrichment analyses, the
CALM/AF10
-positive samples showed significant upregulation of genes involved in chromatin assembly and maintenance and DNA repair process, and downregulation of angiogenesis and cell communication genes. Interestingly, we observed a striking upregulation of four genes located immediately centromeric to the break point of the t(10;11)(p12;q14) on 10p12 (
COMMD3
(COMM domain containing 3),
BMI1
(B lymphoma Mo-MLV insertion region 1 homolog),
DNAJC1
(DnaJ (Hsp40) homolog subfamily C member 1) and
SPAG6
(sperm associated antigen 6)). We also conducted semiquantitative reverse transcriptase-PCR analysis on leukemic blasts from a murine
CALM/AF10
transplantation model that does not have the translocation.
Commd3
,
Bmi1
and
Dnajc1
, but not
Spag6
were upregulated in these samples. These results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the
CALM/AF10
fusion gene expression, though the mechanism of regulation is not well understood.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2011.307</identifier><identifier>PMID: 22064352</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Acute myeloid leukemia ; Analysis ; Angiogenesis ; Animals ; Antigens ; Assembly ; B-cell lymphoma ; Biological and medical sciences ; Bone marrow ; Cancer Research ; Care and treatment ; Cell interactions ; Chromatin Assembly and Disassembly - genetics ; Chromatin remodeling ; Chromosome Fragile Sites ; Chromosome translocations ; Chromosomes, Human, Pair 10 ; Critical Care Medicine ; Deoxyribonucleic acid ; DNA ; DNA methylation ; DNA repair ; DNA Repair - genetics ; Fusion protein ; Gene expression ; Gene regulation ; Genes ; Genetic aspects ; Genomics ; Health aspects ; Heat shock proteins ; Hematologic and hematopoietic diseases ; Hematology ; Homology ; Hsp40 protein ; Humans ; Intensive ; Internal Medicine ; Leukemia ; Leukemia - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic leukemia ; Lymphoma ; Medical sciences ; Medicine ; Medicine & Public Health ; Mice ; Monomeric Clathrin Assembly Proteins - genetics ; Oncology ; original-article ; Physiological aspects ; Proteins ; Repair ; Reverse Transcriptase Polymerase Chain Reaction ; Risk factors ; RNA-directed DNA polymerase ; Transcription Factors - genetics ; Translocation ; Translocation, Genetic ; Transplantation ; Transplants & implants ; Up-Regulation</subject><ispartof>Leukemia, 2012-05, Vol.26 (5), p.1012-1019</ispartof><rights>Macmillan Publishers Limited 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2012</rights><rights>Macmillan Publishers Limited 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c650t-72579c664e82c39a82f327677f195d086e1ba32eeb0987dad6ca4b752854dc1d3</citedby><cites>FETCH-LOGICAL-c650t-72579c664e82c39a82f327677f195d086e1ba32eeb0987dad6ca4b752854dc1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2011.307$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2011.307$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25883987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22064352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mulaw, M A</creatorcontrib><creatorcontrib>Krause, A J</creatorcontrib><creatorcontrib>Deshpande, A J</creatorcontrib><creatorcontrib>Krause, L F</creatorcontrib><creatorcontrib>Rouhi, A</creatorcontrib><creatorcontrib>La Starza, R</creatorcontrib><creatorcontrib>Borkhardt, A</creatorcontrib><creatorcontrib>Buske, C</creatorcontrib><creatorcontrib>Mecucci, C</creatorcontrib><creatorcontrib>Ludwig, W-D</creatorcontrib><creatorcontrib>Lottaz, C</creatorcontrib><creatorcontrib>Bohlander, S K</creatorcontrib><title>CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the
CALM/AF10
fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of
CALM/AF10
-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 normal bone marrow samples. Based on gene set enrichment analyses, the
CALM/AF10
-positive samples showed significant upregulation of genes involved in chromatin assembly and maintenance and DNA repair process, and downregulation of angiogenesis and cell communication genes. Interestingly, we observed a striking upregulation of four genes located immediately centromeric to the break point of the t(10;11)(p12;q14) on 10p12 (
COMMD3
(COMM domain containing 3),
BMI1
(B lymphoma Mo-MLV insertion region 1 homolog),
DNAJC1
(DnaJ (Hsp40) homolog subfamily C member 1) and
SPAG6
(sperm associated antigen 6)). We also conducted semiquantitative reverse transcriptase-PCR analysis on leukemic blasts from a murine
CALM/AF10
transplantation model that does not have the translocation.
Commd3
,
Bmi1
and
Dnajc1
, but not
Spag6
were upregulated in these samples. These results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the
CALM/AF10
fusion gene expression, though the mechanism of regulation is not well understood.</description><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Acute myeloid leukemia</subject><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Antigens</subject><subject>Assembly</subject><subject>B-cell lymphoma</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell interactions</subject><subject>Chromatin Assembly and Disassembly - genetics</subject><subject>Chromatin remodeling</subject><subject>Chromosome Fragile Sites</subject><subject>Chromosome translocations</subject><subject>Chromosomes, Human, Pair 10</subject><subject>Critical Care Medicine</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA repair</subject><subject>DNA Repair - genetics</subject><subject>Fusion protein</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Heat shock proteins</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Homology</subject><subject>Hsp40 protein</subject><subject>Humans</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemia - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic leukemia</subject><subject>Lymphoma</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Monomeric Clathrin Assembly Proteins - genetics</subject><subject>Oncology</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Repair</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk factors</subject><subject>RNA-directed DNA polymerase</subject><subject>Transcription Factors - genetics</subject><subject>Translocation</subject><subject>Translocation, Genetic</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Up-Regulation</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEokvhxhlZQiAOZGs7cewcV4UCUoELnCPHmex6m9ipnSzqv-GnMmGXfqAKIR9s-X08M555k-Q5o0tGM3XSwbTklLFlRuWDZMFyWaRCCPYwWVClZFqUPD9KnsS4pXQWi8fJEee0yDPBF8nP09X555PVGaPp4KMd7Q4IRryA3upI4sb_INMQYD11erTeEd-SNTiIxLqd73bQ4IGYTfA96o7oGKGvuyuiXUPefVmRAIO2gQzBG0At_haug-hmqw24kYyejBsgdQB9MXiLN3okjA6MP00etbqL8OywHyffz95_O_2Ynn_98AmLT00h6JhKLmRpiiIHxU1WasXbjMtCypaVoqGqAFbrjAPUtFSy0U1hdF5LwZXIG8Oa7Dh5s4-LpV5OEMeqt9FA12kHfooVw-Yxmiue_w-KDVZ5RhF9-Re69VNw-JGKF7mQvMQ5_IvCWExIpkp-Q611B5V1rR-DNnPqasVLysssExKp5T0UrgZHaryD1uL9nQevbz3YgO7GTfTdNI873gXf7kETfIwB2moIttfhCousZitWaJxqtmKFVkT8xeFTU91Dcw3_8R4Crw6AjkZ3bdDO2HjDCaUynBVy6Z6LKLk1hNvduSfxL2hl8Rw</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Mulaw, M A</creator><creator>Krause, A J</creator><creator>Deshpande, A J</creator><creator>Krause, L F</creator><creator>Rouhi, A</creator><creator>La Starza, R</creator><creator>Borkhardt, A</creator><creator>Buske, C</creator><creator>Mecucci, C</creator><creator>Ludwig, W-D</creator><creator>Lottaz, C</creator><creator>Bohlander, S K</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>20120501</creationdate><title>CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12</title><author>Mulaw, M A ; Krause, A J ; Deshpande, A J ; Krause, L F ; Rouhi, A ; La Starza, R ; Borkhardt, A ; Buske, C ; Mecucci, C ; Ludwig, W-D ; Lottaz, C ; Bohlander, S K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c650t-72579c664e82c39a82f327677f195d086e1ba32eeb0987dad6ca4b752854dc1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Acute lymphocytic leukemia</topic><topic>Acute myeloid leukemia</topic><topic>Analysis</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Antigens</topic><topic>Assembly</topic><topic>B-cell lymphoma</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Cell interactions</topic><topic>Chromatin Assembly and Disassembly - genetics</topic><topic>Chromatin remodeling</topic><topic>Chromosome Fragile Sites</topic><topic>Chromosome translocations</topic><topic>Chromosomes, Human, Pair 10</topic><topic>Critical Care Medicine</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA repair</topic><topic>DNA Repair - genetics</topic><topic>Fusion protein</topic><topic>Gene expression</topic><topic>Gene regulation</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Heat shock proteins</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Homology</topic><topic>Hsp40 protein</topic><topic>Humans</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukemia - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic leukemia</topic><topic>Lymphoma</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Monomeric Clathrin Assembly Proteins - genetics</topic><topic>Oncology</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Repair</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Risk factors</topic><topic>RNA-directed DNA polymerase</topic><topic>Transcription Factors - genetics</topic><topic>Translocation</topic><topic>Translocation, Genetic</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mulaw, M A</creatorcontrib><creatorcontrib>Krause, A J</creatorcontrib><creatorcontrib>Deshpande, A J</creatorcontrib><creatorcontrib>Krause, L F</creatorcontrib><creatorcontrib>Rouhi, A</creatorcontrib><creatorcontrib>La Starza, R</creatorcontrib><creatorcontrib>Borkhardt, A</creatorcontrib><creatorcontrib>Buske, C</creatorcontrib><creatorcontrib>Mecucci, C</creatorcontrib><creatorcontrib>Ludwig, W-D</creatorcontrib><creatorcontrib>Lottaz, C</creatorcontrib><creatorcontrib>Bohlander, S K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mulaw, M A</au><au>Krause, A J</au><au>Deshpande, A J</au><au>Krause, L F</au><au>Rouhi, A</au><au>La Starza, R</au><au>Borkhardt, A</au><au>Buske, C</au><au>Mecucci, C</au><au>Ludwig, W-D</au><au>Lottaz, C</au><au>Bohlander, S K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>26</volume><issue>5</issue><spage>1012</spage><epage>1019</epage><pages>1012-1019</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the
CALM/AF10
fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of
CALM/AF10
-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 normal bone marrow samples. Based on gene set enrichment analyses, the
CALM/AF10
-positive samples showed significant upregulation of genes involved in chromatin assembly and maintenance and DNA repair process, and downregulation of angiogenesis and cell communication genes. Interestingly, we observed a striking upregulation of four genes located immediately centromeric to the break point of the t(10;11)(p12;q14) on 10p12 (
COMMD3
(COMM domain containing 3),
BMI1
(B lymphoma Mo-MLV insertion region 1 homolog),
DNAJC1
(DnaJ (Hsp40) homolog subfamily C member 1) and
SPAG6
(sperm associated antigen 6)). We also conducted semiquantitative reverse transcriptase-PCR analysis on leukemic blasts from a murine
CALM/AF10
transplantation model that does not have the translocation.
Commd3
,
Bmi1
and
Dnajc1
, but not
Spag6
were upregulated in these samples. These results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the
CALM/AF10
fusion gene expression, though the mechanism of regulation is not well understood.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22064352</pmid><doi>10.1038/leu.2011.307</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2012-05, Vol.26 (5), p.1012-1019 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1014104824 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute lymphoblastic leukemia Acute lymphocytic leukemia Acute myeloid leukemia Analysis Angiogenesis Animals Antigens Assembly B-cell lymphoma Biological and medical sciences Bone marrow Cancer Research Care and treatment Cell interactions Chromatin Assembly and Disassembly - genetics Chromatin remodeling Chromosome Fragile Sites Chromosome translocations Chromosomes, Human, Pair 10 Critical Care Medicine Deoxyribonucleic acid DNA DNA methylation DNA repair DNA Repair - genetics Fusion protein Gene expression Gene regulation Genes Genetic aspects Genomics Health aspects Heat shock proteins Hematologic and hematopoietic diseases Hematology Homology Hsp40 protein Humans Intensive Internal Medicine Leukemia Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphoma Medical sciences Medicine Medicine & Public Health Mice Monomeric Clathrin Assembly Proteins - genetics Oncology original-article Physiological aspects Proteins Repair Reverse Transcriptase Polymerase Chain Reaction Risk factors RNA-directed DNA polymerase Transcription Factors - genetics Translocation Translocation, Genetic Transplantation Transplants & implants Up-Regulation |
| title | CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A02%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CALM/AF10-positive%20leukemias%20show%20upregulation%20of%20genes%20involved%20in%20chromatin%20assembly%20and%20DNA%20repair%20processes%20and%20of%20genes%20adjacent%20to%20the%20breakpoint%20at%2010p12&rft.jtitle=Leukemia&rft.au=Mulaw,%20M%20A&rft.date=2012-05-01&rft.volume=26&rft.issue=5&rft.spage=1012&rft.epage=1019&rft.pages=1012-1019&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/leu.2011.307&rft_dat=%3Cgale_proqu%3EA290293357%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1011571892&rft_id=info:pmid/22064352&rft_galeid=A290293357&rfr_iscdi=true |