Bacillus atrophaeus inactivated spores as a potential adjuvant for veterinary rabies vaccine

Highlights ► B. atrophaeus inactivated spores (BAIS) were tested as adjuvant for rabies vaccine. ► BAIS proved to be as effective as the adjuvant saponin in a murine model. ► BAIS and saponin combined resulted in even higher antibody titers against rabies. ► The combined formulation maintained viabi...

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Veröffentlicht in:	Vaccine 2012-05, Vol.30 (23), p.3351-3354
Hauptverfasser:	Oliveira-Nascimento, L, Caricati, A.T.P, Abdulack-Lopes, F, Neves, L.C.M, Caricati, C.P, Penna, T.C.V, Stephano, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - chemistry adverse effects Allergy and Immunology Aluminum Animals Antibodies Antibodies, Viral - blood Bacillus Bacillus - chemistry Bacillus - immunology Bacillus atrophaeus Bites Combined vaccines Drug Stability Encephalitis Mice Rabies Rabies Vaccines - administration & dosage Rabies Vaccines - immunology Rabies virus Saponin Saponins Side effects Spores Spores, Bacterial - chemistry Spores, Bacterial - immunology Toxicity vaccination Vaccine Vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Veterinary Medicine - methods viability viral encephalitis
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Zusammenfassung:	Highlights ► B. atrophaeus inactivated spores (BAIS) were tested as adjuvant for rabies vaccine. ► BAIS proved to be as effective as the adjuvant saponin in a murine model. ► BAIS and saponin combined resulted in even higher antibody titers against rabies. ► The combined formulation maintained viability for 21 months when stored at 4–8 °C.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.03.029