Serotonin Transporter Knockout Rats Show Improved Strategy Set-Shifting and Reduced Latent Inhibition
Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT[superscript -/-]) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral fl...
Gespeichert in:
| Veröffentlicht in: | Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2012-05, Vol.19 (5), p.190-193 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 193 |
|---|---|
| container_issue | 5 |
| container_start_page | 190 |
| container_title | Learning & memory (Cold Spring Harbor, N.Y.) |
| container_volume | 19 |
| creator | Nonkes, Lourens J. P van de Vondervoort, Ilse I. G. M de Leeuw, Mark J. C Wijlaars, Linda P Maes, Joseph H. R Homberg, Judith R |
| description | Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT[superscript -/-]) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT[superscript -/-] rodents as well. Here we subjected 5-HTT[superscript -/-] rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT[superscript -/-] rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism. |
| doi_str_mv | 10.1101/lm.025908.112 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1014101865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ericid>EJ973716</ericid><sourcerecordid>1014101865</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-6340cf5a8a137cdcee9a5181d0f337641a4135a0c9f0d3ffb8529471a220c22e3</originalsourceid><addsrcrecordid>eNqN0Utv3CAQAGBUpWpePfZWRRxzcTqAMfYxijbJtitFWm_PFovHWVobNoBb5d-HaNOce0Awmk8zaIaQLwyuGAP2bZyugMsG6hzyD-SEybIpZFnLo_wGxQuQwI_JaYy_AECpkn0ix5xLkIqzE4ItBp-8s45ugnZx70PCQH84b377OdG1TpG2O_-XLqd98H-wp20KOuHjM20xFe3ODsm6R6pdT9fYzyaLVc67RJduZ7c2We_OycdBjxE_v91n5OftYnNzX6we7pY316vCiLpKRSVKMIPUtWZCmd4gNlqymvUwCKGqkumSCanBNAP0Yhi2teRNqZjmHAznKM7I5aFu_urTjDF1k40Gx1E79HPs8sDKfOpK_gcF1sjclGdaHKgJPsaAQ7cPdtLhOaPudQndOHWHJeTw1V-8lZ63E_bv-t_UM_h6ABiseU8vvjdKKFaJF8W-iyo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1001957642</pqid></control><display><type>article</type><title>Serotonin Transporter Knockout Rats Show Improved Strategy Set-Shifting and Reduced Latent Inhibition</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Nonkes, Lourens J. P ; van de Vondervoort, Ilse I. G. M ; de Leeuw, Mark J. C ; Wijlaars, Linda P ; Maes, Joseph H. R ; Homberg, Judith R</creator><creatorcontrib>Nonkes, Lourens J. P ; van de Vondervoort, Ilse I. G. M ; de Leeuw, Mark J. C ; Wijlaars, Linda P ; Maes, Joseph H. R ; Homberg, Judith R</creatorcontrib><description>Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT[superscript -/-]) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT[superscript -/-] rodents as well. Here we subjected 5-HTT[superscript -/-] rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT[superscript -/-] rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.</description><identifier>ISSN: 1072-0502</identifier><identifier>ISSN: 1549-5485</identifier><identifier>EISSN: 1549-5485</identifier><identifier>DOI: 10.1101/lm.025908.112</identifier><identifier>PMID: 22505721</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Behavior, Animal - physiology ; Brain ; Cognitive ability ; Cognitive Processes ; Comparative Analysis ; Control Groups ; Cortex (prefrontal) ; Environmental changes ; Experimental Psychology ; Experiments ; Gene Knockout Techniques ; Inhibition ; Inhibition (Psychology) ; Latent inhibition ; Learning Processes ; Prefrontal Cortex - metabolism ; Rats ; Rats, Wistar ; Recall (Psychology) ; Reversal learning ; Serotonin Plasma Membrane Transport Proteins - metabolism ; Serotonin transporter ; Task Analysis</subject><ispartof>Learning & memory (Cold Spring Harbor, N.Y.), 2012-05, Vol.19 (5), p.190-193</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6340cf5a8a137cdcee9a5181d0f337641a4135a0c9f0d3ffb8529471a220c22e3</citedby><cites>FETCH-LOGICAL-c386t-6340cf5a8a137cdcee9a5181d0f337641a4135a0c9f0d3ffb8529471a220c22e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ973716$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22505721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nonkes, Lourens J. P</creatorcontrib><creatorcontrib>van de Vondervoort, Ilse I. G. M</creatorcontrib><creatorcontrib>de Leeuw, Mark J. C</creatorcontrib><creatorcontrib>Wijlaars, Linda P</creatorcontrib><creatorcontrib>Maes, Joseph H. R</creatorcontrib><creatorcontrib>Homberg, Judith R</creatorcontrib><title>Serotonin Transporter Knockout Rats Show Improved Strategy Set-Shifting and Reduced Latent Inhibition</title><title>Learning & memory (Cold Spring Harbor, N.Y.)</title><addtitle>Learn Mem</addtitle><description>Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT[superscript -/-]) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT[superscript -/-] rodents as well. Here we subjected 5-HTT[superscript -/-] rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT[superscript -/-] rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Brain</subject><subject>Cognitive ability</subject><subject>Cognitive Processes</subject><subject>Comparative Analysis</subject><subject>Control Groups</subject><subject>Cortex (prefrontal)</subject><subject>Environmental changes</subject><subject>Experimental Psychology</subject><subject>Experiments</subject><subject>Gene Knockout Techniques</subject><subject>Inhibition</subject><subject>Inhibition (Psychology)</subject><subject>Latent inhibition</subject><subject>Learning Processes</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recall (Psychology)</subject><subject>Reversal learning</subject><subject>Serotonin Plasma Membrane Transport Proteins - metabolism</subject><subject>Serotonin transporter</subject><subject>Task Analysis</subject><issn>1072-0502</issn><issn>1549-5485</issn><issn>1549-5485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0Utv3CAQAGBUpWpePfZWRRxzcTqAMfYxijbJtitFWm_PFovHWVobNoBb5d-HaNOce0Awmk8zaIaQLwyuGAP2bZyugMsG6hzyD-SEybIpZFnLo_wGxQuQwI_JaYy_AECpkn0ix5xLkIqzE4ItBp-8s45ugnZx70PCQH84b377OdG1TpG2O_-XLqd98H-wp20KOuHjM20xFe3ODsm6R6pdT9fYzyaLVc67RJduZ7c2We_OycdBjxE_v91n5OftYnNzX6we7pY316vCiLpKRSVKMIPUtWZCmd4gNlqymvUwCKGqkumSCanBNAP0Yhi2teRNqZjmHAznKM7I5aFu_urTjDF1k40Gx1E79HPs8sDKfOpK_gcF1sjclGdaHKgJPsaAQ7cPdtLhOaPudQndOHWHJeTw1V-8lZ63E_bv-t_UM_h6ABiseU8vvjdKKFaJF8W-iyo</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Nonkes, Lourens J. P</creator><creator>van de Vondervoort, Ilse I. G. M</creator><creator>de Leeuw, Mark J. C</creator><creator>Wijlaars, Linda P</creator><creator>Maes, Joseph H. R</creator><creator>Homberg, Judith R</creator><general>Cold Spring Harbor Laboratory Press</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20120501</creationdate><title>Serotonin Transporter Knockout Rats Show Improved Strategy Set-Shifting and Reduced Latent Inhibition</title><author>Nonkes, Lourens J. P ; van de Vondervoort, Ilse I. G. M ; de Leeuw, Mark J. C ; Wijlaars, Linda P ; Maes, Joseph H. R ; Homberg, Judith R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6340cf5a8a137cdcee9a5181d0f337641a4135a0c9f0d3ffb8529471a220c22e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Brain</topic><topic>Cognitive ability</topic><topic>Cognitive Processes</topic><topic>Comparative Analysis</topic><topic>Control Groups</topic><topic>Cortex (prefrontal)</topic><topic>Environmental changes</topic><topic>Experimental Psychology</topic><topic>Experiments</topic><topic>Gene Knockout Techniques</topic><topic>Inhibition</topic><topic>Inhibition (Psychology)</topic><topic>Latent inhibition</topic><topic>Learning Processes</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recall (Psychology)</topic><topic>Reversal learning</topic><topic>Serotonin Plasma Membrane Transport Proteins - metabolism</topic><topic>Serotonin transporter</topic><topic>Task Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nonkes, Lourens J. P</creatorcontrib><creatorcontrib>van de Vondervoort, Ilse I. G. M</creatorcontrib><creatorcontrib>de Leeuw, Mark J. C</creatorcontrib><creatorcontrib>Wijlaars, Linda P</creatorcontrib><creatorcontrib>Maes, Joseph H. R</creatorcontrib><creatorcontrib>Homberg, Judith R</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Learning & memory (Cold Spring Harbor, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nonkes, Lourens J. P</au><au>van de Vondervoort, Ilse I. G. M</au><au>de Leeuw, Mark J. C</au><au>Wijlaars, Linda P</au><au>Maes, Joseph H. R</au><au>Homberg, Judith R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ973716</ericid><atitle>Serotonin Transporter Knockout Rats Show Improved Strategy Set-Shifting and Reduced Latent Inhibition</atitle><jtitle>Learning & memory (Cold Spring Harbor, N.Y.)</jtitle><addtitle>Learn Mem</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>19</volume><issue>5</issue><spage>190</spage><epage>193</epage><pages>190-193</pages><issn>1072-0502</issn><issn>1549-5485</issn><eissn>1549-5485</eissn><abstract>Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT[superscript -/-]) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT[superscript -/-] rodents as well. Here we subjected 5-HTT[superscript -/-] rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT[superscript -/-] rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>22505721</pmid><doi>10.1101/lm.025908.112</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1072-0502 |
| ispartof | Learning & memory (Cold Spring Harbor, N.Y.), 2012-05, Vol.19 (5), p.190-193 |
| issn | 1072-0502 1549-5485 1549-5485 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1014101865 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Behavior, Animal - physiology Brain Cognitive ability Cognitive Processes Comparative Analysis Control Groups Cortex (prefrontal) Environmental changes Experimental Psychology Experiments Gene Knockout Techniques Inhibition Inhibition (Psychology) Latent inhibition Learning Processes Prefrontal Cortex - metabolism Rats Rats, Wistar Recall (Psychology) Reversal learning Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin transporter Task Analysis |
| title | Serotonin Transporter Knockout Rats Show Improved Strategy Set-Shifting and Reduced Latent Inhibition |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T22%3A51%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serotonin%20Transporter%20Knockout%20Rats%20Show%20Improved%20Strategy%20Set-Shifting%20and%20Reduced%20Latent%20Inhibition&rft.jtitle=Learning%20&%20memory%20(Cold%20Spring%20Harbor,%20N.Y.)&rft.au=Nonkes,%20Lourens%20J.%20P&rft.date=2012-05-01&rft.volume=19&rft.issue=5&rft.spage=190&rft.epage=193&rft.pages=190-193&rft.issn=1072-0502&rft.eissn=1549-5485&rft_id=info:doi/10.1101/lm.025908.112&rft_dat=%3Cproquest_cross%3E1014101865%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1001957642&rft_id=info:pmid/22505721&rft_ericid=EJ973716&rfr_iscdi=true |