Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile
A series of truncated analogs of α-galactosylceramide with altered ceramide moiety was prepared, and evaluated for Th2-biased response in the context of IL-4/IFN-γ ratio. Phytosphingosine-modified analogs including cyclic, aromatic and ethereal compounds as well as the C-glycoside analog of OCH (2)...
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Veröffentlicht in: | Bioorganic & medicinal chemistry 2012-05, Vol.20 (9), p.2850-2859 |
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Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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