NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterized by peribronchial and perivascular inflammation and largely irreversible airflow obstruction. Acute disease exacerbations, due frequently to viral infections, lead to enhanced disease symptoms and contribute to long-term progression of COP...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-05, Vol.188 (9), p.4468-4475
Hauptverfasser:	Wortham, Brian W, Eppert, Bryan L, Motz, Greg T, Flury, Jennifer L, Orozco-Levi, Mauricio, Hoebe, Kasper, Panos, Ralph J, Maxfield, Melissa, Glasser, Stephan W, Senft, Albert P, Raulet, David H, Borchers, Michael T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - immunology Cytokines - genetics Cytokines - immunology Disease Models, Animal Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humans Influenza A Virus, H3N2 Subtype - immunology Killer Cells, Natural - immunology Killer Cells, Natural - pathology Mice Mice, Knockout NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - immunology Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Pulmonary Disease, Chronic Obstructive - chemically induced Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - virology Tobacco Smoke Pollution - adverse effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!