Analytical Characterization of an Orally-Delivered Peptide Pharmaceutical Product

The characterization of orally-delivered peptide pharmaceuticals presents several challenges to analytical methods in comparison to characterization of conventional small-molecule drugs. These challenges include the analysis and characterization of difficult-to-separate impurities, secondary structu...

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Veröffentlicht in:	Analytical chemistry (Washington) 2012-05, Vol.84 (10), p.4357-4372
Hauptverfasser:	Kelley, Wayne P, Chen, Shujun, Floyd, Philip D, Hu, Ping, Kapsi, Shiva G, Kord, Alireza S, Sun, Mingjiang, Vogt, Frederick G
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amino Acid Sequence Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, High Pressure Liquid Drug Compounding Exact sciences and technology Humans Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Sequence Data Molecular structure Other chromatographic methods Parathyroid Hormone - analysis Parathyroid Hormone - genetics Parathyroid Hormone - metabolism Peptides Peptides - analysis Pharmaceuticals Protein Structure, Secondary Recombinant Proteins - analysis Recombinant Proteins - genetics Recombinant Proteins - metabolism Spectrometric and optical methods Spectrum Analysis, Raman Sucrose - chemistry
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