miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts

Keloids are a fibroproliferative disease due to abnormal wound healing process after skin injury. They are characterized by overproduction of extracellular matrix (ECM) such as collagens. MicroRNAs (miRNAs) are noncoding small RNAs and negatively regulate protein expression. Several miRNAs that have...

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Veröffentlicht in:	Journal of investigative dermatology 2012-06, Vol.132 (6), p.1597-1604
Hauptverfasser:	Kashiyama, Kazuya, Mitsutake, Norisato, Matsuse, Michiko, Ogi, Tomoo, Saenko, Vladimir A., Ujifuku, Kenta, Utani, Atsushi, Hirano, Akiyoshi, Yamashita, Shunichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Collagen Type I - genetics Collagen Type III - genetics CpG Islands - genetics Dermatology Dermis - cytology DNA Methylation - physiology Down-Regulation - genetics Female Fibroblasts - cytology Fibroblasts - physiology Humans Keloid - genetics Keloid - pathology Keloid - physiopathology Luciferases - genetics Male Medical sciences MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Primary Cell Culture Promoter Regions, Genetic - genetics Real-Time Polymerase Chain Reaction Skin involvement in other diseases. Miscellaneous. General aspects Young Adult
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