Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog
– The prognosis for a reimplanted tooth depends largely on the condition of the root. Platelet‐derived growth factor (PDGF)‐BB has been shown to regenerate periodontal tissue in animal and human clinical studies. However, information regarding the effect of PDGF‐BB on tooth reimplantation is limite...
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| Veröffentlicht in: | Dental traumatology 2012-06, Vol.28 (3), p.217-225 |
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| creator | Noda, Katsuya Seshima, Fumi Okubo, Nobuki Ishii, Yoshihito Ota, Mikio Yamada, Satroru Saito, Atsushi |
| description | – The prognosis for a reimplanted tooth depends largely on the condition of the root. Platelet‐derived growth factor (PDGF)‐BB has been shown to regenerate periodontal tissue in animal and human clinical studies. However, information regarding the effect of PDGF‐BB on tooth reimplantation is limited. The objective of this study was to investigate the effect of PDGF‐BB on root resorption after reimplantation of a partially denuded tooth in dog. A total of 15 healthy female beagle dogs were used. Mandibular third and fourth premolars were endodontically treated and then extracted as atraumatically as possible. The coronal portion of each root was carefully scaled and planed. The roots on the right side of the mandible were treated with PDGF‐BB and reimplanted, while the roots on the left side served as controls. After 2, 4, or 8 weeks, specimens were collected and processed for histopathological examination. By the 4th week after reimplantation, new periodontal ligament (PDL)‐like tissue had formed around the PDGF‐BB‐treated root surfaces and new bone. By the 8th week, healing of the PDGF‐BB‐treated roots was characterized by newly formed PDL with inserting attachment formation. In contrast, control roots showed multiple areas of replacement resorption. Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) performed at 2 weeks after reimplantation showed that the number of PCNA‐positive cells in the connective tissue area was statistically significantly greater in the PDGF‐BB‐treated group than in the control group (P |
| doi_str_mv | 10.1111/j.1600-9657.2011.01070.x |
| format | Article |
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Platelet‐derived growth factor (PDGF)‐BB has been shown to regenerate periodontal tissue in animal and human clinical studies. However, information regarding the effect of PDGF‐BB on tooth reimplantation is limited. The objective of this study was to investigate the effect of PDGF‐BB on root resorption after reimplantation of a partially denuded tooth in dog. A total of 15 healthy female beagle dogs were used. Mandibular third and fourth premolars were endodontically treated and then extracted as atraumatically as possible. The coronal portion of each root was carefully scaled and planed. The roots on the right side of the mandible were treated with PDGF‐BB and reimplanted, while the roots on the left side served as controls. After 2, 4, or 8 weeks, specimens were collected and processed for histopathological examination. By the 4th week after reimplantation, new periodontal ligament (PDL)‐like tissue had formed around the PDGF‐BB‐treated root surfaces and new bone. By the 8th week, healing of the PDGF‐BB‐treated roots was characterized by newly formed PDL with inserting attachment formation. In contrast, control roots showed multiple areas of replacement resorption. Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) performed at 2 weeks after reimplantation showed that the number of PCNA‐positive cells in the connective tissue area was statistically significantly greater in the PDGF‐BB‐treated group than in the control group (P < 0.001). The application of PDGF‐BB resulted in a significantly lower occurrence and extent of root resorption and ankylosis. These results suggest that the use of PDGF‐BB reduces occurrence of ankylosis and root resorption in tooth reimplantation.</description><identifier>ISSN: 1600-4469</identifier><identifier>EISSN: 1600-9657</identifier><identifier>DOI: 10.1111/j.1600-9657.2011.01070.x</identifier><identifier>PMID: 22051114</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Angiogenesis Inducing Agents - therapeutic use ; Animals ; Dentistry ; Dogs ; Female ; Periodontal Ligament - drug effects ; Periodontal Ligament - pathology ; Periodontal Ligament - surgery ; Proliferating Cell Nuclear Antigen - drug effects ; Proto-Oncogene Proteins c-sis - therapeutic use ; Regeneration - drug effects ; Root Resorption - drug therapy ; Root Resorption - prevention & control ; Tooth Replantation - methods ; Tooth Root - drug effects ; Tooth Root - pathology ; Tooth Root - physiology ; Tooth Root - surgery</subject><ispartof>Dental traumatology, 2012-06, Vol.28 (3), p.217-225</ispartof><rights>2011 John Wiley & Sons A/S</rights><rights>2011 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4070-51b876e1d0477d59843ba6cdde4dfa79e2a96ee151e68eb498e1403d2c8d54d13</citedby><cites>FETCH-LOGICAL-c4070-51b876e1d0477d59843ba6cdde4dfa79e2a96ee151e68eb498e1403d2c8d54d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-9657.2011.01070.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-9657.2011.01070.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22051114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noda, Katsuya</creatorcontrib><creatorcontrib>Seshima, Fumi</creatorcontrib><creatorcontrib>Okubo, Nobuki</creatorcontrib><creatorcontrib>Ishii, Yoshihito</creatorcontrib><creatorcontrib>Ota, Mikio</creatorcontrib><creatorcontrib>Yamada, Satroru</creatorcontrib><creatorcontrib>Saito, Atsushi</creatorcontrib><title>Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog</title><title>Dental traumatology</title><addtitle>Dent Traumatol</addtitle><description>– The prognosis for a reimplanted tooth depends largely on the condition of the root. Platelet‐derived growth factor (PDGF)‐BB has been shown to regenerate periodontal tissue in animal and human clinical studies. However, information regarding the effect of PDGF‐BB on tooth reimplantation is limited. The objective of this study was to investigate the effect of PDGF‐BB on root resorption after reimplantation of a partially denuded tooth in dog. A total of 15 healthy female beagle dogs were used. Mandibular third and fourth premolars were endodontically treated and then extracted as atraumatically as possible. The coronal portion of each root was carefully scaled and planed. The roots on the right side of the mandible were treated with PDGF‐BB and reimplanted, while the roots on the left side served as controls. After 2, 4, or 8 weeks, specimens were collected and processed for histopathological examination. By the 4th week after reimplantation, new periodontal ligament (PDL)‐like tissue had formed around the PDGF‐BB‐treated root surfaces and new bone. By the 8th week, healing of the PDGF‐BB‐treated roots was characterized by newly formed PDL with inserting attachment formation. In contrast, control roots showed multiple areas of replacement resorption. Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) performed at 2 weeks after reimplantation showed that the number of PCNA‐positive cells in the connective tissue area was statistically significantly greater in the PDGF‐BB‐treated group than in the control group (P < 0.001). The application of PDGF‐BB resulted in a significantly lower occurrence and extent of root resorption and ankylosis. These results suggest that the use of PDGF‐BB reduces occurrence of ankylosis and root resorption in tooth reimplantation.</description><subject>Angiogenesis Inducing Agents - therapeutic use</subject><subject>Animals</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Female</subject><subject>Periodontal Ligament - drug effects</subject><subject>Periodontal Ligament - pathology</subject><subject>Periodontal Ligament - surgery</subject><subject>Proliferating Cell Nuclear Antigen - drug effects</subject><subject>Proto-Oncogene Proteins c-sis - therapeutic use</subject><subject>Regeneration - drug effects</subject><subject>Root Resorption - drug therapy</subject><subject>Root Resorption - prevention & control</subject><subject>Tooth Replantation - methods</subject><subject>Tooth Root - drug effects</subject><subject>Tooth Root - pathology</subject><subject>Tooth Root - physiology</subject><subject>Tooth Root - surgery</subject><issn>1600-4469</issn><issn>1600-9657</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtz2yAUhZlOMnk1f6HDshupIBCIRRdN6jxm8tgkbXcMFlcJrmxcQI3974Nix-uw4d7L-Q5wEMKUlDSvb7OSCkIKJWpZVoTSklAiSbn6hI52B3vbmnOhDtFxjDNCqJCKHKDDqiJ19uFHaJh0HbQJ-w4ve5Ogh1RYCO4_WPwU_Et6xp1pkw_F2Rn2Cxy8TzhA9GGZXO5NlyDkgZtnfJHM23A0MyE50_drbGEx2OyWMvmM3QJb__QZ7Xemj3C63U_Q48Xk4fyquLm_vD7_cVO0PP-nqOm0kQKoJVxKW6uGs6kRrbXAbWekgsooAUBrCqKBKVcNUE6YrdrG1txSdoK-bnyXwf8bICY9d7GFPj8V_BA1JZQpqljDsrTZSNvgYwzQ6WVwcxPWWaTH0PVMj3nqMVs9hq7fQterjH7Z3jJM52B34HvKWfB9I3hxPaw_bKwnPx_GKvPFhncxwWrHm_BXC8lkrX_fXWpxywj78-tCV-wVWUyghQ</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Noda, Katsuya</creator><creator>Seshima, Fumi</creator><creator>Okubo, Nobuki</creator><creator>Ishii, Yoshihito</creator><creator>Ota, Mikio</creator><creator>Yamada, Satroru</creator><creator>Saito, Atsushi</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog</title><author>Noda, Katsuya ; Seshima, Fumi ; Okubo, Nobuki ; Ishii, Yoshihito ; Ota, Mikio ; Yamada, Satroru ; Saito, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4070-51b876e1d0477d59843ba6cdde4dfa79e2a96ee151e68eb498e1403d2c8d54d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Angiogenesis Inducing Agents - therapeutic use</topic><topic>Animals</topic><topic>Dentistry</topic><topic>Dogs</topic><topic>Female</topic><topic>Periodontal Ligament - drug effects</topic><topic>Periodontal Ligament - pathology</topic><topic>Periodontal Ligament - surgery</topic><topic>Proliferating Cell Nuclear Antigen - drug effects</topic><topic>Proto-Oncogene Proteins c-sis - therapeutic use</topic><topic>Regeneration - drug effects</topic><topic>Root Resorption - drug therapy</topic><topic>Root Resorption - prevention & control</topic><topic>Tooth Replantation - methods</topic><topic>Tooth Root - drug effects</topic><topic>Tooth Root - pathology</topic><topic>Tooth Root - physiology</topic><topic>Tooth Root - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noda, Katsuya</creatorcontrib><creatorcontrib>Seshima, Fumi</creatorcontrib><creatorcontrib>Okubo, Nobuki</creatorcontrib><creatorcontrib>Ishii, Yoshihito</creatorcontrib><creatorcontrib>Ota, Mikio</creatorcontrib><creatorcontrib>Yamada, Satroru</creatorcontrib><creatorcontrib>Saito, Atsushi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dental traumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noda, Katsuya</au><au>Seshima, Fumi</au><au>Okubo, Nobuki</au><au>Ishii, Yoshihito</au><au>Ota, Mikio</au><au>Yamada, Satroru</au><au>Saito, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog</atitle><jtitle>Dental traumatology</jtitle><addtitle>Dent Traumatol</addtitle><date>2012-06</date><risdate>2012</risdate><volume>28</volume><issue>3</issue><spage>217</spage><epage>225</epage><pages>217-225</pages><issn>1600-4469</issn><eissn>1600-9657</eissn><abstract>– The prognosis for a reimplanted tooth depends largely on the condition of the root. Platelet‐derived growth factor (PDGF)‐BB has been shown to regenerate periodontal tissue in animal and human clinical studies. However, information regarding the effect of PDGF‐BB on tooth reimplantation is limited. The objective of this study was to investigate the effect of PDGF‐BB on root resorption after reimplantation of a partially denuded tooth in dog. A total of 15 healthy female beagle dogs were used. Mandibular third and fourth premolars were endodontically treated and then extracted as atraumatically as possible. The coronal portion of each root was carefully scaled and planed. The roots on the right side of the mandible were treated with PDGF‐BB and reimplanted, while the roots on the left side served as controls. After 2, 4, or 8 weeks, specimens were collected and processed for histopathological examination. By the 4th week after reimplantation, new periodontal ligament (PDL)‐like tissue had formed around the PDGF‐BB‐treated root surfaces and new bone. By the 8th week, healing of the PDGF‐BB‐treated roots was characterized by newly formed PDL with inserting attachment formation. In contrast, control roots showed multiple areas of replacement resorption. Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) performed at 2 weeks after reimplantation showed that the number of PCNA‐positive cells in the connective tissue area was statistically significantly greater in the PDGF‐BB‐treated group than in the control group (P < 0.001). The application of PDGF‐BB resulted in a significantly lower occurrence and extent of root resorption and ankylosis. These results suggest that the use of PDGF‐BB reduces occurrence of ankylosis and root resorption in tooth reimplantation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22051114</pmid><doi>10.1111/j.1600-9657.2011.01070.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Dental traumatology, 2012-06, Vol.28 (3), p.217-225 |
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| subjects | Angiogenesis Inducing Agents - therapeutic use Animals Dentistry Dogs Female Periodontal Ligament - drug effects Periodontal Ligament - pathology Periodontal Ligament - surgery Proliferating Cell Nuclear Antigen - drug effects Proto-Oncogene Proteins c-sis - therapeutic use Regeneration - drug effects Root Resorption - drug therapy Root Resorption - prevention & control Tooth Replantation - methods Tooth Root - drug effects Tooth Root - pathology Tooth Root - physiology Tooth Root - surgery |
| title | Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog |
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