Coffee Component 3-Caffeoylquinic Acid Increases Antioxidant Capacity but not Polyphenol Content in Experimental Cerebral Infarction
Although coffee has antioxidant capacity, it is not known which of its bioactive compounds is responsible for it, nor has it been analyzed in experimental cerebral infarction. We studied the effect one of its compounds, 3-caffeoylquinic acid (3-CQA), at doses of 4, 25 and 100 μg on plasma antioxidan...
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| Veröffentlicht in: | Neurochemical research 2012-05, Vol.37 (5), p.1085-1090 |
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| creator | Ruiz-Crespo, Silvia Trejo-Gabriel-Galan, Jose M Cavia-Saiz, Monica Muniz, Pilar |
| description | Although coffee has antioxidant capacity, it is not known which of its bioactive compounds is responsible for it, nor has it been analyzed in experimental cerebral infarction. We studied the effect one of its compounds, 3-caffeoylquinic acid (3-CQA), at doses of 4, 25 and 100 μg on plasma antioxidant capacity and plasma polyphenol content, measuring the differences before and after inducing a cerebral infarction in an experimental rat model. We compared them with 3-caffeoylquinic-free controls. The increase in total antioxidant capacity was only higher than in controls in 3-CQA treated animals with the highest dose. This increase in antioxidant capacity was not due to an increase in polyphenols. No differences between the experimental and control group were found regarding polyphenol content and cerebral infarction volume. In conclusion, this increase in antioxidant capacity in the group that received the highest dose of 3-CQA was not able to reduce experimental cerebral infarction. |
| doi_str_mv | 10.1007/s11064-012-0711-7 |
| format | Article |
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We studied the effect one of its compounds, 3-caffeoylquinic acid (3-CQA), at doses of 4, 25 and 100 μg on plasma antioxidant capacity and plasma polyphenol content, measuring the differences before and after inducing a cerebral infarction in an experimental rat model. We compared them with 3-caffeoylquinic-free controls. The increase in total antioxidant capacity was only higher than in controls in 3-CQA treated animals with the highest dose. This increase in antioxidant capacity was not due to an increase in polyphenols. No differences between the experimental and control group were found regarding polyphenol content and cerebral infarction volume. In conclusion, this increase in antioxidant capacity in the group that received the highest dose of 3-CQA was not able to reduce experimental cerebral infarction.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-012-0711-7</identifier><identifier>PMID: 22297726</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Antioxidants - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cerebral Infarction - metabolism ; Chlorogenic Acid - pharmacology ; Coffee - chemistry ; Male ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Polyphenols - metabolism ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Neurochemical research, 2012-05, Vol.37 (5), p.1085-1090</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-59a649afe40feb69bd8c5a822530c8fd73483b154fd5638123f0eb3b9971be173</citedby><cites>FETCH-LOGICAL-c404t-59a649afe40feb69bd8c5a822530c8fd73483b154fd5638123f0eb3b9971be173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-012-0711-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-012-0711-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22297726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz-Crespo, Silvia</creatorcontrib><creatorcontrib>Trejo-Gabriel-Galan, Jose M</creatorcontrib><creatorcontrib>Cavia-Saiz, Monica</creatorcontrib><creatorcontrib>Muniz, Pilar</creatorcontrib><title>Coffee Component 3-Caffeoylquinic Acid Increases Antioxidant Capacity but not Polyphenol Content in Experimental Cerebral Infarction</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Although coffee has antioxidant capacity, it is not known which of its bioactive compounds is responsible for it, nor has it been analyzed in experimental cerebral infarction. 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In conclusion, this increase in antioxidant capacity in the group that received the highest dose of 3-CQA was not able to reduce experimental cerebral infarction.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cerebral Infarction - metabolism</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>Coffee - chemistry</subject><subject>Male</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Polyphenols - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkcFu1DAQhi1ERZeFB-CCIk69BGbsJI6Pq6iUlSrBoZwjxxmDq6yd2onUvfPgeLUFJCQkTrZn_vlmPD9jbxDeI4D8kBChqUpAXoJELOUztsFairJRIJ6zDYicFajgkr1M6R4gV3F8wS4550pK3mzYjy5YS1R04TAHT34pRNnpHArH6WF13pliZ9xY7L2JpBOlYucXFx7dqLO207M2bjkWw7oUPizFlzAd5-_kw5SJfjnxnC-uH2eK7pBfOscp0hDzZe-tjibD_Ct2YfWU6PXTuWVfP17fdZ_K2883-253W5oKqqWslW4qpS1VYGlo1DC2ptYt57UA09pRiqoVA9aVHetGtMiFBRrEoJTEgVCKLbs6c-cYHlZKS39wydA0aU9hTT0CCoVKcPgPKbRtVUNutGXv_pLehzX6_JE-L7mVUEvMIjyLTAwpRbL9nDei4zGTTjDZn83ss5n9ycz-NO7bJ_A6HGj8XfHLvSzgZ0HKKf-N4p_O_6b-BPJFqhY</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Ruiz-Crespo, Silvia</creator><creator>Trejo-Gabriel-Galan, Jose M</creator><creator>Cavia-Saiz, Monica</creator><creator>Muniz, Pilar</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Coffee Component 3-Caffeoylquinic Acid Increases Antioxidant Capacity but not Polyphenol Content in Experimental Cerebral Infarction</title><author>Ruiz-Crespo, Silvia ; 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| subjects | Animals Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cerebral Infarction - metabolism Chlorogenic Acid - pharmacology Coffee - chemistry Male Neurochemistry Neurology Neurosciences Original Paper Polyphenols - metabolism Rats Rats, Sprague-Dawley |
| title | Coffee Component 3-Caffeoylquinic Acid Increases Antioxidant Capacity but not Polyphenol Content in Experimental Cerebral Infarction |
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