First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia
Summary Background First‐degree relatives (FDRs) of early‐onset gastric carcinoma (EOGC) patients are at increased risk of cancer development. OLGA/OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification of individuals at high ri...
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| creator | Marcos-Pinto, R. Carneiro, F. Dinis-Ribeiro, M. Wen, X. Lopes, C. Figueiredo, C. Machado, J. C. Ferreira, R. M. Reis, C. A. Ferreira, J. Pedroto, I. Areias, J. |
| description | Summary
Background
First‐degree relatives (FDRs) of early‐onset gastric carcinoma (EOGC) patients are at increased risk of cancer development. OLGA/OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification of individuals at high risk of gastric cancer development.
Aim
To estimate the prevalence and severity of premalignant conditions and lesions in FDRs of EOGC patients.
Methods
A case–control study was conducted encompassing 103 FDRs of EOGC patients (cases) and 101 age‐ and gender‐matched controls, all submitted to upper GI endoscopy and OLGA and OLGIM used for staging as well as modified versions with exclusion of the biopsies from incisura angularis in the analysis.
Results
Helicobacter pylori infection was present in 82% of cases (P = 0.001). Atrophy was present in 70% of cases (OLGA stages I–IV). High‐risk stages (III–IV) were identified only in cases (19%) (P |
| doi_str_mv | 10.1111/j.1365-2036.2012.05111.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1013918263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1013918263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4871-4560c132622c18cc45785fedbf0f76cbe67885321acb7b9e7aa303cc87ebb5723</originalsourceid><addsrcrecordid>eNqNkc2O0zAUhSMEYsrAKyBvkNik45_GdhcsqoopIwrDiCKW1o1z07qkSbHTnzzLvOw4tJQtXthH9nfuvfJJEsLokMV1sx4yIbOUUyGHnDI-pFm8Hh6fJYPLw_NkQLkcp1wzcZW8CmFNKZWK8pfJFefZSI_GfJA83jof2rTApUckHito3R4DaUqyjRLrNpCDa1cEwVdd2tQBW7KE0HpniQVvXd1sgIRVcyC4x5pAS7pmVy8JLGMZICu3XJGtxz1UWFvsC0OxhygLcj-fTW7idveFhPbE1wUpurCtIDh4nbwooQr45nxeJz9uPy6mn9L5_exuOpmndqQVS0eZpJYJLjm3TFs7ypTOSizykpZK2hyl0joTnIHNVT5GBSCosFYrzPNMcXGdvD_V3frm9w5DazYuWKwqqLHZBcMoE2OmuRQR1SfU-iYEj6XZercB30XI9NGYtekTMH0Cpo_G_InGHKP17bnLLt9gcTH-zSIC784ABAtV6eMnufCPy8aMSd3P8OHEHVyF3X8PYCbfFr2K_vTkd6HF48UP_peRSqjM_Pw6M2wxffiu5GfzIJ4AWdS6XA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1013918263</pqid></control><display><type>article</type><title>First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Marcos-Pinto, R. ; Carneiro, F. ; Dinis-Ribeiro, M. ; Wen, X. ; Lopes, C. ; Figueiredo, C. ; Machado, J. C. ; Ferreira, R. M. ; Reis, C. A. ; Ferreira, J. ; Pedroto, I. ; Areias, J.</creator><creatorcontrib>Marcos-Pinto, R. ; Carneiro, F. ; Dinis-Ribeiro, M. ; Wen, X. ; Lopes, C. ; Figueiredo, C. ; Machado, J. C. ; Ferreira, R. M. ; Reis, C. A. ; Ferreira, J. ; Pedroto, I. ; Areias, J.</creatorcontrib><description>Summary
Background
First‐degree relatives (FDRs) of early‐onset gastric carcinoma (EOGC) patients are at increased risk of cancer development. OLGA/OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification of individuals at high risk of gastric cancer development.
Aim
To estimate the prevalence and severity of premalignant conditions and lesions in FDRs of EOGC patients.
Methods
A case–control study was conducted encompassing 103 FDRs of EOGC patients (cases) and 101 age‐ and gender‐matched controls, all submitted to upper GI endoscopy and OLGA and OLGIM used for staging as well as modified versions with exclusion of the biopsies from incisura angularis in the analysis.
Results
Helicobacter pylori infection was present in 82% of cases (P = 0.001). Atrophy was present in 70% of cases (OLGA stages I–IV). High‐risk stages (III–IV) were identified only in cases (19%) (P < 0.001). Dysplasia was diagnosed only in cases (n = 7, P = 0.007). The application of OLGIM, modified OLGA and modified OLGIM classifications led to downgrade of stages in comparison with the original OLGA classification (27%, 15% and 30% respectively). In all classification systems, dysplastic lesions clustered (86%) in high‐risk stages.
Conclusions
FDRs of EOGC patients have, even at young ages, a high prevalence of H. pylori infection, high‐risk OLGA and OLGIM stages and dysplasia. These patients should undergo accurate endoscopic observation with at least four biopsies in antrum and corpus to allow adequate staging and follow‐up of premalignant conditions and lesions scored in high‐risk stages, in accordance with international guidelines recently proposed.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2012.05111.x</identifier><identifier>PMID: 22548492</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Biological and medical sciences ; Case-Control Studies ; Digestive system ; Endoscopy, Gastrointestinal - methods ; Female ; Gastritis - microbiology ; Gastritis - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - pathology ; Helicobacter pylori - isolation & purification ; Humans ; Male ; Medical sciences ; Metaplasia - pathology ; Pedigree ; Pharmacology. Drug treatments ; Precancerous Conditions - chemically induced ; Precancerous Conditions - pathology ; Risk Factors ; Severity of Illness Index ; Statistics as Topic ; Stomach - pathology ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Time Factors ; Tumors</subject><ispartof>Alimentary pharmacology & therapeutics, 2012-06, Vol.35 (12), p.1451-1459</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2012 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4871-4560c132622c18cc45785fedbf0f76cbe67885321acb7b9e7aa303cc87ebb5723</citedby><cites>FETCH-LOGICAL-c4871-4560c132622c18cc45785fedbf0f76cbe67885321acb7b9e7aa303cc87ebb5723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2012.05111.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2012.05111.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25911683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22548492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcos-Pinto, R.</creatorcontrib><creatorcontrib>Carneiro, F.</creatorcontrib><creatorcontrib>Dinis-Ribeiro, M.</creatorcontrib><creatorcontrib>Wen, X.</creatorcontrib><creatorcontrib>Lopes, C.</creatorcontrib><creatorcontrib>Figueiredo, C.</creatorcontrib><creatorcontrib>Machado, J. C.</creatorcontrib><creatorcontrib>Ferreira, R. M.</creatorcontrib><creatorcontrib>Reis, C. A.</creatorcontrib><creatorcontrib>Ferreira, J.</creatorcontrib><creatorcontrib>Pedroto, I.</creatorcontrib><creatorcontrib>Areias, J.</creatorcontrib><title>First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
First‐degree relatives (FDRs) of early‐onset gastric carcinoma (EOGC) patients are at increased risk of cancer development. OLGA/OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification of individuals at high risk of gastric cancer development.
Aim
To estimate the prevalence and severity of premalignant conditions and lesions in FDRs of EOGC patients.
Methods
A case–control study was conducted encompassing 103 FDRs of EOGC patients (cases) and 101 age‐ and gender‐matched controls, all submitted to upper GI endoscopy and OLGA and OLGIM used for staging as well as modified versions with exclusion of the biopsies from incisura angularis in the analysis.
Results
Helicobacter pylori infection was present in 82% of cases (P = 0.001). Atrophy was present in 70% of cases (OLGA stages I–IV). High‐risk stages (III–IV) were identified only in cases (19%) (P < 0.001). Dysplasia was diagnosed only in cases (n = 7, P = 0.007). The application of OLGIM, modified OLGA and modified OLGIM classifications led to downgrade of stages in comparison with the original OLGA classification (27%, 15% and 30% respectively). In all classification systems, dysplastic lesions clustered (86%) in high‐risk stages.
Conclusions
FDRs of EOGC patients have, even at young ages, a high prevalence of H. pylori infection, high‐risk OLGA and OLGIM stages and dysplasia. These patients should undergo accurate endoscopic observation with at least four biopsies in antrum and corpus to allow adequate staging and follow‐up of premalignant conditions and lesions scored in high‐risk stages, in accordance with international guidelines recently proposed.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Digestive system</subject><subject>Endoscopy, Gastrointestinal - methods</subject><subject>Female</subject><subject>Gastritis - microbiology</subject><subject>Gastritis - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metaplasia - pathology</subject><subject>Pedigree</subject><subject>Pharmacology. Drug treatments</subject><subject>Precancerous Conditions - chemically induced</subject><subject>Precancerous Conditions - pathology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Statistics as Topic</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhSMEYsrAKyBvkNik45_GdhcsqoopIwrDiCKW1o1z07qkSbHTnzzLvOw4tJQtXthH9nfuvfJJEsLokMV1sx4yIbOUUyGHnDI-pFm8Hh6fJYPLw_NkQLkcp1wzcZW8CmFNKZWK8pfJFefZSI_GfJA83jof2rTApUckHito3R4DaUqyjRLrNpCDa1cEwVdd2tQBW7KE0HpniQVvXd1sgIRVcyC4x5pAS7pmVy8JLGMZICu3XJGtxz1UWFvsC0OxhygLcj-fTW7idveFhPbE1wUpurCtIDh4nbwooQr45nxeJz9uPy6mn9L5_exuOpmndqQVS0eZpJYJLjm3TFs7ypTOSizykpZK2hyl0joTnIHNVT5GBSCosFYrzPNMcXGdvD_V3frm9w5DazYuWKwqqLHZBcMoE2OmuRQR1SfU-iYEj6XZercB30XI9NGYtekTMH0Cpo_G_InGHKP17bnLLt9gcTH-zSIC784ABAtV6eMnufCPy8aMSd3P8OHEHVyF3X8PYCbfFr2K_vTkd6HF48UP_peRSqjM_Pw6M2wxffiu5GfzIJ4AWdS6XA</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Marcos-Pinto, R.</creator><creator>Carneiro, F.</creator><creator>Dinis-Ribeiro, M.</creator><creator>Wen, X.</creator><creator>Lopes, C.</creator><creator>Figueiredo, C.</creator><creator>Machado, J. C.</creator><creator>Ferreira, R. M.</creator><creator>Reis, C. A.</creator><creator>Ferreira, J.</creator><creator>Pedroto, I.</creator><creator>Areias, J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia</title><author>Marcos-Pinto, R. ; Carneiro, F. ; Dinis-Ribeiro, M. ; Wen, X. ; Lopes, C. ; Figueiredo, C. ; Machado, J. C. ; Ferreira, R. M. ; Reis, C. A. ; Ferreira, J. ; Pedroto, I. ; Areias, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4871-4560c132622c18cc45785fedbf0f76cbe67885321acb7b9e7aa303cc87ebb5723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Digestive system</topic><topic>Endoscopy, Gastrointestinal - methods</topic><topic>Female</topic><topic>Gastritis - microbiology</topic><topic>Gastritis - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metaplasia - pathology</topic><topic>Pedigree</topic><topic>Pharmacology. Drug treatments</topic><topic>Precancerous Conditions - chemically induced</topic><topic>Precancerous Conditions - pathology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Statistics as Topic</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marcos-Pinto, R.</creatorcontrib><creatorcontrib>Carneiro, F.</creatorcontrib><creatorcontrib>Dinis-Ribeiro, M.</creatorcontrib><creatorcontrib>Wen, X.</creatorcontrib><creatorcontrib>Lopes, C.</creatorcontrib><creatorcontrib>Figueiredo, C.</creatorcontrib><creatorcontrib>Machado, J. C.</creatorcontrib><creatorcontrib>Ferreira, R. M.</creatorcontrib><creatorcontrib>Reis, C. A.</creatorcontrib><creatorcontrib>Ferreira, J.</creatorcontrib><creatorcontrib>Pedroto, I.</creatorcontrib><creatorcontrib>Areias, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcos-Pinto, R.</au><au>Carneiro, F.</au><au>Dinis-Ribeiro, M.</au><au>Wen, X.</au><au>Lopes, C.</au><au>Figueiredo, C.</au><au>Machado, J. C.</au><au>Ferreira, R. M.</au><au>Reis, C. A.</au><au>Ferreira, J.</au><au>Pedroto, I.</au><au>Areias, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2012-06</date><risdate>2012</risdate><volume>35</volume><issue>12</issue><spage>1451</spage><epage>1459</epage><pages>1451-1459</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
First‐degree relatives (FDRs) of early‐onset gastric carcinoma (EOGC) patients are at increased risk of cancer development. OLGA/OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification of individuals at high risk of gastric cancer development.
Aim
To estimate the prevalence and severity of premalignant conditions and lesions in FDRs of EOGC patients.
Methods
A case–control study was conducted encompassing 103 FDRs of EOGC patients (cases) and 101 age‐ and gender‐matched controls, all submitted to upper GI endoscopy and OLGA and OLGIM used for staging as well as modified versions with exclusion of the biopsies from incisura angularis in the analysis.
Results
Helicobacter pylori infection was present in 82% of cases (P = 0.001). Atrophy was present in 70% of cases (OLGA stages I–IV). High‐risk stages (III–IV) were identified only in cases (19%) (P < 0.001). Dysplasia was diagnosed only in cases (n = 7, P = 0.007). The application of OLGIM, modified OLGA and modified OLGIM classifications led to downgrade of stages in comparison with the original OLGA classification (27%, 15% and 30% respectively). In all classification systems, dysplastic lesions clustered (86%) in high‐risk stages.
Conclusions
FDRs of EOGC patients have, even at young ages, a high prevalence of H. pylori infection, high‐risk OLGA and OLGIM stages and dysplasia. These patients should undergo accurate endoscopic observation with at least four biopsies in antrum and corpus to allow adequate staging and follow‐up of premalignant conditions and lesions scored in high‐risk stages, in accordance with international guidelines recently proposed.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22548492</pmid><doi>10.1111/j.1365-2036.2012.05111.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Biological and medical sciences Case-Control Studies Digestive system Endoscopy, Gastrointestinal - methods Female Gastritis - microbiology Gastritis - pathology Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - pathology Helicobacter pylori - isolation & purification Humans Male Medical sciences Metaplasia - pathology Pedigree Pharmacology. Drug treatments Precancerous Conditions - chemically induced Precancerous Conditions - pathology Risk Factors Severity of Illness Index Statistics as Topic Stomach - pathology Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Tumors |
| title | First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia |
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