Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection
Introduction Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angio...
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| Veröffentlicht in: | Surgical endoscopy 2012-06, Vol.26 (6), p.1759-1764 |
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| creator | Shantha Kumara, H. M. C. Tohme, Samer T. Herath, Sonali A. C. Yan, Xiaohong Senagore, Anthony J. Nasar, Abu Kalady, Matthew F. Baxter, Raymond Whelan, Richard L. |
| description | Introduction
Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study’s purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients.
Methods
Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3, and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student’s
t
test was used for data analysis (significance,
P
|
| doi_str_mv | 10.1007/s00464-011-2112-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1013918228</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1013918228</sourcerecordid><originalsourceid>FETCH-LOGICAL-p212t-9006bba09c02800faf4f41c95ac0576b82228d2deeb6318d4952da25aacba34c3</originalsourceid><addsrcrecordid>eNpdkU1P3DAQhi0EYre0P6CXyhKXXlz8lWxyrBCFSkjtAc7WxJmwWTkfeBwkfgD_Gy8LUtWT5ZnH77yel7GvSv5QUm4uSEpbWiGVElopLewRWytrtNBaVcdsLWsjhd7UdsU-Ee1kxmtVnLKVzkCdFdbs5W8AGoDTFJYmIH8C8kuAyKHdIvXTyIcpYC6hUDzgEwbiEJHPGKmnhGMKzxxzAxK2vF1iPz7wtEXe9ZFSfjymLYcuYeR-ClNEnyBwD6PPlYiU73nIZ3bSQSD88n6esftfV3eXN-L2z_Xvy5-3YtZKJ5Etl00DsvZSV1J20NnOKl8X4GWxKZsq_6tqdYvYlEZVra0L3YIuAHwDxnpzxr4fdOc4PS5IyQ09eQwBRpwWckoqU6ssU2X0_D90Ny1xzO7eqNJUZrOnvr1TSzNg6-bYDxCf3ceCM6APAM371WD8V8btU3SHFF1O0e1TdNa8Alyfjwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1013638378</pqid></control><display><type>article</type><title>Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Shantha Kumara, H. M. C. ; Tohme, Samer T. ; Herath, Sonali A. C. ; Yan, Xiaohong ; Senagore, Anthony J. ; Nasar, Abu ; Kalady, Matthew F. ; Baxter, Raymond ; Whelan, Richard L.</creator><creatorcontrib>Shantha Kumara, H. M. C. ; Tohme, Samer T. ; Herath, Sonali A. C. ; Yan, Xiaohong ; Senagore, Anthony J. ; Nasar, Abu ; Kalady, Matthew F. ; Baxter, Raymond ; Whelan, Richard L.</creatorcontrib><description>Introduction
Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study’s purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients.
Methods
Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3, and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student’s
t
test was used for data analysis (significance,
P
< 0.008 after Bonferroni correction).
Results
The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM-1 level was significantly higher on POD 1 (905.7 ± 292.4,
P
< 0.001) and POD 3 (977.7 ± 271.8,
P
< 0.001). Levels remained significantly elevated for the POD 7–13, POD 14–20, POD 21–27, and POD 28–67 time blocks.
Conclusions
MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-011-2112-4</identifier><identifier>PMID: 22219007</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adenocarcinoma - blood ; Adenocarcinoma - surgery ; Aged ; Angiogenesis ; Antigens ; Cell adhesion & migration ; Colonic Neoplasms - blood ; Colonic Neoplasms - surgery ; Colorectal cancer ; Enzyme-Linked Immunosorbent Assay ; Female ; Gastroenterology ; Gynecology ; Hepatology ; Humans ; Laparoscopy - methods ; Length of Stay ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm, Residual - blood ; Plasma ; Postoperative Period ; Proctology ; Proteins ; Surgery ; Vascular Cell Adhesion Molecule-1 - metabolism</subject><ispartof>Surgical endoscopy, 2012-06, Vol.26 (6), p.1759-1764</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p212t-9006bba09c02800faf4f41c95ac0576b82228d2deeb6318d4952da25aacba34c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-011-2112-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-011-2112-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22219007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shantha Kumara, H. M. C.</creatorcontrib><creatorcontrib>Tohme, Samer T.</creatorcontrib><creatorcontrib>Herath, Sonali A. C.</creatorcontrib><creatorcontrib>Yan, Xiaohong</creatorcontrib><creatorcontrib>Senagore, Anthony J.</creatorcontrib><creatorcontrib>Nasar, Abu</creatorcontrib><creatorcontrib>Kalady, Matthew F.</creatorcontrib><creatorcontrib>Baxter, Raymond</creatorcontrib><creatorcontrib>Whelan, Richard L.</creatorcontrib><title>Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Introduction
Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study’s purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients.
Methods
Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3, and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student’s
t
test was used for data analysis (significance,
P
< 0.008 after Bonferroni correction).
Results
The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM-1 level was significantly higher on POD 1 (905.7 ± 292.4,
P
< 0.001) and POD 3 (977.7 ± 271.8,
P
< 0.001). Levels remained significantly elevated for the POD 7–13, POD 14–20, POD 21–27, and POD 28–67 time blocks.
Conclusions
MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Antigens</subject><subject>Cell adhesion & migration</subject><subject>Colonic Neoplasms - blood</subject><subject>Colonic Neoplasms - surgery</subject><subject>Colorectal cancer</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Laparoscopy - methods</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm, Residual - blood</subject><subject>Plasma</subject><subject>Postoperative Period</subject><subject>Proctology</subject><subject>Proteins</subject><subject>Surgery</subject><subject>Vascular Cell Adhesion Molecule-1 - metabolism</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1P3DAQhi0EYre0P6CXyhKXXlz8lWxyrBCFSkjtAc7WxJmwWTkfeBwkfgD_Gy8LUtWT5ZnH77yel7GvSv5QUm4uSEpbWiGVElopLewRWytrtNBaVcdsLWsjhd7UdsU-Ee1kxmtVnLKVzkCdFdbs5W8AGoDTFJYmIH8C8kuAyKHdIvXTyIcpYC6hUDzgEwbiEJHPGKmnhGMKzxxzAxK2vF1iPz7wtEXe9ZFSfjymLYcuYeR-ClNEnyBwD6PPlYiU73nIZ3bSQSD88n6esftfV3eXN-L2z_Xvy5-3YtZKJ5Etl00DsvZSV1J20NnOKl8X4GWxKZsq_6tqdYvYlEZVra0L3YIuAHwDxnpzxr4fdOc4PS5IyQ09eQwBRpwWckoqU6ssU2X0_D90Ny1xzO7eqNJUZrOnvr1TSzNg6-bYDxCf3ceCM6APAM371WD8V8btU3SHFF1O0e1TdNa8Alyfjwg</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Shantha Kumara, H. M. C.</creator><creator>Tohme, Samer T.</creator><creator>Herath, Sonali A. C.</creator><creator>Yan, Xiaohong</creator><creator>Senagore, Anthony J.</creator><creator>Nasar, Abu</creator><creator>Kalady, Matthew F.</creator><creator>Baxter, Raymond</creator><creator>Whelan, Richard L.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection</title><author>Shantha Kumara, H. M. C. ; Tohme, Samer T. ; Herath, Sonali A. C. ; Yan, Xiaohong ; Senagore, Anthony J. ; Nasar, Abu ; Kalady, Matthew F. ; Baxter, Raymond ; Whelan, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p212t-9006bba09c02800faf4f41c95ac0576b82228d2deeb6318d4952da25aacba34c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Angiogenesis</topic><topic>Antigens</topic><topic>Cell adhesion & migration</topic><topic>Colonic Neoplasms - blood</topic><topic>Colonic Neoplasms - surgery</topic><topic>Colorectal cancer</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Laparoscopy - methods</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm, Residual - blood</topic><topic>Plasma</topic><topic>Postoperative Period</topic><topic>Proctology</topic><topic>Proteins</topic><topic>Surgery</topic><topic>Vascular Cell Adhesion Molecule-1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shantha Kumara, H. M. C.</creatorcontrib><creatorcontrib>Tohme, Samer T.</creatorcontrib><creatorcontrib>Herath, Sonali A. C.</creatorcontrib><creatorcontrib>Yan, Xiaohong</creatorcontrib><creatorcontrib>Senagore, Anthony J.</creatorcontrib><creatorcontrib>Nasar, Abu</creatorcontrib><creatorcontrib>Kalady, Matthew F.</creatorcontrib><creatorcontrib>Baxter, Raymond</creatorcontrib><creatorcontrib>Whelan, Richard L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shantha Kumara, H. M. C.</au><au>Tohme, Samer T.</au><au>Herath, Sonali A. C.</au><au>Yan, Xiaohong</au><au>Senagore, Anthony J.</au><au>Nasar, Abu</au><au>Kalady, Matthew F.</au><au>Baxter, Raymond</au><au>Whelan, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>26</volume><issue>6</issue><spage>1759</spage><epage>1764</epage><pages>1759-1764</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><abstract>Introduction
Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study’s purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients.
Methods
Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3, and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student’s
t
test was used for data analysis (significance,
P
< 0.008 after Bonferroni correction).
Results
The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM-1 level was significantly higher on POD 1 (905.7 ± 292.4,
P
< 0.001) and POD 3 (977.7 ± 271.8,
P
< 0.001). Levels remained significantly elevated for the POD 7–13, POD 14–20, POD 21–27, and POD 28–67 time blocks.
Conclusions
MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22219007</pmid><doi>10.1007/s00464-011-2112-4</doi><tpages>6</tpages></addata></record> |
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| issn | 0930-2794 1432-2218 |
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| subjects | Abdominal Surgery Adenocarcinoma - blood Adenocarcinoma - surgery Aged Angiogenesis Antigens Cell adhesion & migration Colonic Neoplasms - blood Colonic Neoplasms - surgery Colorectal cancer Enzyme-Linked Immunosorbent Assay Female Gastroenterology Gynecology Hepatology Humans Laparoscopy - methods Length of Stay Male Medicine Medicine & Public Health Middle Aged Neoplasm, Residual - blood Plasma Postoperative Period Proctology Proteins Surgery Vascular Cell Adhesion Molecule-1 - metabolism |
| title | Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection |
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