Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading

The Mis18 complex has been identified as a critical factor for the centromeric localization of a histone H3 variant, centromeric protein A (CENP-A), which is responsible for the specification of centromere identity in the chromosome. However, the functional role of Mis18 complex is largely unknown....

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Veröffentlicht in:	Molecular cell 2012-05, Vol.46 (3), p.260-273
Hauptverfasser:	Kim, Ik Soo, Lee, Minkyoung, Park, Koog Chan, Jeon, Yoon, Park, Joo Hyeon, Hwang, Eun Ju, Jeon, Tae Im, Ko, Seoyoung, Lee, Ho, Baek, Sung Hee, Kim, Keun Il
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - analysis Autoantigens - metabolism Binding Sites Centromere - genetics Centromere - metabolism Centromere Protein A centromeres chromatin Chromatin - metabolism Chromosomal Proteins, Non-Histone - analysis Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomal Proteins, Non-Histone - physiology chromosome segregation Chromosome Segregation - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Epigenesis, Genetic epigenetics HeLa Cells histones Histones - metabolism Humans knockout mutants mammals Mice Mice, Knockout Protein Interaction Mapping
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