Down-regulation of spinal d-amino acid oxidase expression blocks formalin-induced tonic pain

► siRNA/DAAO and Ad-shDAAO inhibited spinal DAAO expression and enzymatic activity. ► siRNA/DAAO and Ad-shDAAO prevented formalin-induced tonic phase pain. ► siRNA/DAAO and Ad-shDAAO blocked spinal expression of GFAP. A series of inhibitors of d-amino acid oxidase (DAAO) are specific in blocking chr...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-05, Vol.421 (3), p.501-507
Hauptverfasser:	Chen, Xiao-Ling, Li, Xin-Yan, Qian, Su-Bo, Wang, Yan-Chao, Zhang, Pei-Zhuo, Zhou, Xian-Jun, Wang, Yong-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia - methods Animals Astrocytes - enzymology Astrocytes - physiology Chronic pain d-Amino acid oxidase (DAAO) D-Amino-Acid Oxidase - antagonists & inhibitors D-Amino-Acid Oxidase - genetics Down-Regulation Epithelial Cells - enzymology Formaldehyde - pharmacology Formalin test Gene silencing Injections, Spinal Kidney Tubules - enzymology Male Pain - chemically induced Pain - enzymology Pain - physiopathology Rats Rats, Sprague-Dawley RNA interfere RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Spinal cord Spinal Cord - enzymology Spinal Cord - physiopathology Transgenes
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