Sterile spondylodiscitis
In reports of gouty arthritis involving the spine, most patients were male, had a history of gout, presented with neurological deficits and localised pain, and had high concentrations of urate and inflammatory markers in the serum.1-3 The latter finding is probably a result of the release of interle...
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| Veröffentlicht in: | The Lancet (British edition) 2012-05, Vol.379 (9828), p.1850-1850 |
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| creator | Rufener, Janine, MD Schulze, Christina Claudia, MD Tänzler, Kristina, MD Aeberli, Daniel, MD Sendi, Parham, Dr |
| description | In reports of gouty arthritis involving the spine, most patients were male, had a history of gout, presented with neurological deficits and localised pain, and had high concentrations of urate and inflammatory markers in the serum.1-3 The latter finding is probably a result of the release of interleukins by monocytes and synoviocytes reacting to crystals. Spinal gout is predominantly located in the lumbar region.3,4 Radiological findings include vertebral erosions predominantly at the discovertebral junction and epidural space.4 On MRI, these erosions are commonly isointense or hypointense and show homogeneous contrast enhancement.2,3 Several risk factors have been proposed to trigger, or to be associated with, acute attacks of gouty arthritis.5 High urate concentrations in conjunction with previous degenerative change may have predisposed our patient to gouty inflammation. |
| doi_str_mv | 10.1016/S0140-6736(11)61924-7 |
| format | Article |
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Spinal gout is predominantly located in the lumbar region.3,4 Radiological findings include vertebral erosions predominantly at the discovertebral junction and epidural space.4 On MRI, these erosions are commonly isointense or hypointense and show homogeneous contrast enhancement.2,3 Several risk factors have been proposed to trigger, or to be associated with, acute attacks of gouty arthritis.5 High urate concentrations in conjunction with previous degenerative change may have predisposed our patient to gouty inflammation.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(11)61924-7</identifier><identifier>PMID: 22579321</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged, 80 and over ; Arthritis ; Back pain ; Biological and medical sciences ; Biopsy ; Crystals ; Debridement ; Diagnosis, Differential ; Discitis - diagnosis ; Discitis - therapy ; Diseases of the osteoarticular system ; Diseases of the spine ; General aspects ; Gout - diagnosis ; Gout - therapy ; Humans ; Internal Medicine ; Male ; Medical research ; Medical sciences ; Rheumatism ; Risk factors ; Spine</subject><ispartof>The Lancet (British edition), 2012-05, Vol.379 (9828), p.1850-1850</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 12-May 18, 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-5959338af0b8ef1fef41c3ebc37fd2c81f79bd49c5ff7d3fbc4ef4760b044e903</citedby><cites>FETCH-LOGICAL-c478t-5959338af0b8ef1fef41c3ebc37fd2c81f79bd49c5ff7d3fbc4ef4760b044e903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673611619247$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25857048$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22579321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rufener, Janine, MD</creatorcontrib><creatorcontrib>Schulze, Christina Claudia, MD</creatorcontrib><creatorcontrib>Tänzler, Kristina, MD</creatorcontrib><creatorcontrib>Aeberli, Daniel, MD</creatorcontrib><creatorcontrib>Sendi, Parham, Dr</creatorcontrib><title>Sterile spondylodiscitis</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>In reports of gouty arthritis involving the spine, most patients were male, had a history of gout, presented with neurological deficits and localised pain, and had high concentrations of urate and inflammatory markers in the serum.1-3 The latter finding is probably a result of the release of interleukins by monocytes and synoviocytes reacting to crystals. Spinal gout is predominantly located in the lumbar region.3,4 Radiological findings include vertebral erosions predominantly at the discovertebral junction and epidural space.4 On MRI, these erosions are commonly isointense or hypointense and show homogeneous contrast enhancement.2,3 Several risk factors have been proposed to trigger, or to be associated with, acute attacks of gouty arthritis.5 High urate concentrations in conjunction with previous degenerative change may have predisposed our patient to gouty inflammation.</description><subject>Aged, 80 and over</subject><subject>Arthritis</subject><subject>Back pain</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Crystals</subject><subject>Debridement</subject><subject>Diagnosis, Differential</subject><subject>Discitis - diagnosis</subject><subject>Discitis - therapy</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>General aspects</subject><subject>Gout - diagnosis</subject><subject>Gout - therapy</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Rheumatism</subject><subject>Risk factors</subject><subject>Spine</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0M9LwzAUB_AgipvTuxdFEGEeqnlN0rQXRYa_YOBhCt5Cm75AZtfOpBP235v9cINdPOXyed-89yXkDOgNUEhuRxQ4jRLJkj7AdQJZzCO5R7rAJY8El5_7pLshHXLk_ZhSyhMqDkknjoXMWAxdcjpq0dkKL_y0qct51ZTWa9taf0wOTF55PFm_PfLx9Pg-eImGb8-vg4dhpLlM20hkImMszQ0tUjRg0HDQDAvNpCljnYKRWVHyTAtjZMlMoXkgMqEF5Rwzynqkv8qduuZ7hr5Vk7ABVlVeYzPzKhzLZMJkJgK93KHjZubqsN1CceCpZBCUWCntGu8dGjV1dpK7eUALl6hldWrRiwJQy-qUDHPn6_RZMcFyM_XXVQBXa5B7nVfG5bW2futEKiTlaXD3K4ehth-LToVGsdZYWoe6VWVj_13lbidBV7a24dMvnKPfXq18rOgqZJEBsEyQ7BcdvJ2d</recordid><startdate>20120512</startdate><enddate>20120512</enddate><creator>Rufener, Janine, MD</creator><creator>Schulze, Christina Claudia, MD</creator><creator>Tänzler, Kristina, MD</creator><creator>Aeberli, Daniel, MD</creator><creator>Sendi, Parham, Dr</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20120512</creationdate><title>Sterile spondylodiscitis</title><author>Rufener, Janine, MD ; Schulze, Christina Claudia, MD ; Tänzler, Kristina, MD ; Aeberli, Daniel, MD ; Sendi, Parham, Dr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-5959338af0b8ef1fef41c3ebc37fd2c81f79bd49c5ff7d3fbc4ef4760b044e903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged, 80 and over</topic><topic>Arthritis</topic><topic>Back pain</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Crystals</topic><topic>Debridement</topic><topic>Diagnosis, Differential</topic><topic>Discitis - 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rufener, Janine, MD</au><au>Schulze, Christina Claudia, MD</au><au>Tänzler, Kristina, MD</au><au>Aeberli, Daniel, MD</au><au>Sendi, Parham, Dr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sterile spondylodiscitis</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2012-05-12</date><risdate>2012</risdate><volume>379</volume><issue>9828</issue><spage>1850</spage><epage>1850</epage><pages>1850-1850</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>In reports of gouty arthritis involving the spine, most patients were male, had a history of gout, presented with neurological deficits and localised pain, and had high concentrations of urate and inflammatory markers in the serum.1-3 The latter finding is probably a result of the release of interleukins by monocytes and synoviocytes reacting to crystals. Spinal gout is predominantly located in the lumbar region.3,4 Radiological findings include vertebral erosions predominantly at the discovertebral junction and epidural space.4 On MRI, these erosions are commonly isointense or hypointense and show homogeneous contrast enhancement.2,3 Several risk factors have been proposed to trigger, or to be associated with, acute attacks of gouty arthritis.5 High urate concentrations in conjunction with previous degenerative change may have predisposed our patient to gouty inflammation.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22579321</pmid><doi>10.1016/S0140-6736(11)61924-7</doi><tpages>1</tpages></addata></record> |
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| subjects | Aged, 80 and over Arthritis Back pain Biological and medical sciences Biopsy Crystals Debridement Diagnosis, Differential Discitis - diagnosis Discitis - therapy Diseases of the osteoarticular system Diseases of the spine General aspects Gout - diagnosis Gout - therapy Humans Internal Medicine Male Medical research Medical sciences Rheumatism Risk factors Spine |
| title | Sterile spondylodiscitis |
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