Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial–mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma

The high invasiveness and frequent recurrence of lung adenocarcinoma (LAC) are major reasons for treatment failures and poor prognoses. Alterations in microRNAs (miRNAs) expression have been shown in lung cancers. Recent reports have demonstrated that tumors contain a small subpopulation of cancer s...

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Veröffentlicht in:	Journal of controlled release 2012-04, Vol.159 (2), p.240-250
Hauptverfasser:	Chiou, Guang-Yuh, Cherng, Jong-Yuh, Hsu, Han-Shui, Wang, Mong-Lien, Tsai, Chun-Ming, Lu, Kai-Hsi, Chien, Yueh, Hung, Shih-Chieh, Chen, Yi-Wei, Wong, Chiang-Ing, Tseng, Ling-Ming, Huang, Pin-I, Yu, Cheng-Chia, Hsu, Wen-Huh, Chiou, Shih-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Animals Biological and medical sciences Cations Cell Culture Techniques Cell Movement - drug effects Cell Movement - radiation effects Cell Survival - drug effects Cell Survival - genetics Cell Transdifferentiation Cells, Cultured correlation Drug Carriers - chemistry Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Epithelial–mesenchymal transdifferentiation Fascin1 Gamma Rays Gene Transfer Techniques General pharmacology Humans in vivo studies Lung adenocarcinoma lung neoplasms Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences metastasis Mice Mice, Nude microRNA MicroRNAs - administration & dosage MicroRNAs - genetics MicroRNAs - therapeutic use miR145 Neoplasm Invasiveness Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Oct4 patients Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments phenotype Polyethyleneimine - chemistry Polyurethanes - chemistry prognosis relapse reverse transcriptase polymerase chain reaction sorting Sox2 stem cells Tumor Stem Cell Assay
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