Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice
Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Krüppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, li...
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| Veröffentlicht in: | Genetics and molecular research 2011-12, Vol.10 (4), p.3712-3721 |
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| creator | Sun, R L Wang, H Y Yang, X Y Sheng, Z J Li, L M Wang, L Wang, Z G Fei, J |
| description | Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Krüppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan. Three hundred and fifty-five putative target genes were identified, which were enriched into the pathways of immune response according to the pathway analysis. These targets indicated that Zfp191 may function as a mediator of the immune response. This was verified in mice heterozygous for Zfp191 (Zfp191(+/-)) using a lipopolysaccharide (LPS)-induced endotoxic shock model. After LPS injection, Zfp191(+/-) mice produced significantly less IL-1β and IL-6 compared to wild-type mice and were resistant to LPS-induced endotoxic shock. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during LPS-induced endotoxic shock. |
| doi_str_mv | 10.4238/2011.December.8.6 |
| format | Article |
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Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan. Three hundred and fifty-five putative target genes were identified, which were enriched into the pathways of immune response according to the pathway analysis. These targets indicated that Zfp191 may function as a mediator of the immune response. This was verified in mice heterozygous for Zfp191 (Zfp191(+/-)) using a lipopolysaccharide (LPS)-induced endotoxic shock model. After LPS injection, Zfp191(+/-) mice produced significantly less IL-1β and IL-6 compared to wild-type mice and were resistant to LPS-induced endotoxic shock. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during LPS-induced endotoxic shock.</description><identifier>ISSN: 1676-5680</identifier><identifier>EISSN: 1676-5680</identifier><identifier>DOI: 10.4238/2011.December.8.6</identifier><identifier>PMID: 22183946</identifier><language>eng</language><publisher>Brazil</publisher><subject>Animals ; Base Sequence ; Binding Sites ; Carrier Proteins - genetics ; Computational Biology ; Disease Resistance - genetics ; Disease Resistance - immunology ; Gene Expression Regulation ; Gene Knockout Techniques ; Heterozygote ; Interleukin-1beta - blood ; Interleukin-6 - blood ; Lipopolysaccharides ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Organ Specificity ; Protein Binding ; Reverse Transcriptase Polymerase Chain Reaction ; Shock, Septic - blood ; Shock, Septic - genetics ; Shock, Septic - immunology ; Shock, Septic - pathology ; Survival Analysis</subject><ispartof>Genetics and molecular research, 2011-12, Vol.10 (4), p.3712-3721</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-cb850ca9d352e54728c1d85ff96032428bb16534e35fc8a03694c56cffeb1a013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22183946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, R L</creatorcontrib><creatorcontrib>Wang, H Y</creatorcontrib><creatorcontrib>Yang, X Y</creatorcontrib><creatorcontrib>Sheng, Z J</creatorcontrib><creatorcontrib>Li, L M</creatorcontrib><creatorcontrib>Wang, L</creatorcontrib><creatorcontrib>Wang, Z G</creatorcontrib><creatorcontrib>Fei, J</creatorcontrib><title>Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice</title><title>Genetics and molecular research</title><addtitle>Genet Mol Res</addtitle><description>Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Krüppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan. Three hundred and fifty-five putative target genes were identified, which were enriched into the pathways of immune response according to the pathway analysis. These targets indicated that Zfp191 may function as a mediator of the immune response. This was verified in mice heterozygous for Zfp191 (Zfp191(+/-)) using a lipopolysaccharide (LPS)-induced endotoxic shock model. After LPS injection, Zfp191(+/-) mice produced significantly less IL-1β and IL-6 compared to wild-type mice and were resistant to LPS-induced endotoxic shock. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during LPS-induced endotoxic shock.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Carrier Proteins - genetics</subject><subject>Computational Biology</subject><subject>Disease Resistance - genetics</subject><subject>Disease Resistance - immunology</subject><subject>Gene Expression Regulation</subject><subject>Gene Knockout Techniques</subject><subject>Heterozygote</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-6 - blood</subject><subject>Lipopolysaccharides</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular Sequence Data</subject><subject>Organ Specificity</subject><subject>Protein Binding</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - genetics</subject><subject>Shock, Septic - immunology</subject><subject>Shock, Septic - pathology</subject><subject>Survival Analysis</subject><issn>1676-5680</issn><issn>1676-5680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLw0AUhQdRrFZ_gBuZpZvUeXeyFN8gCKIbN2Fyc9OOTTIxk4D115tSK67uWXzncPkIOeNspoS0l4JxPrtBwDrHbmZnZo8ccTM3iTaW7f_LE3Ic4wdjQivLDslECG5lqswRyV8w-ti7BpD2gVa-DW2o1tEBLF3nC0x8UwyABcWmCH348kDjMsCK-oYusccufK8XYYj0vWx5yukCG0xWzUiEoae1BzwhB6WrIp7-3il5u7t9vX5Inp7vH6-vnhJQXPUJ5FYzcGkhtUCt5sICL6wuy9QwKZSwec6NlgqlLsE6Jk2qQBsoS8y5Y1xOycV2t-3C54Cxz2ofAavKNTg-mHHGxVxpKzco36LQhRg7LLO287Xr1iOUbdRmG7XZTm1mMzN2zn_nh7zG4q-xcyl_AGpJd9c</recordid><startdate>20111208</startdate><enddate>20111208</enddate><creator>Sun, R L</creator><creator>Wang, H Y</creator><creator>Yang, X Y</creator><creator>Sheng, Z J</creator><creator>Li, L M</creator><creator>Wang, L</creator><creator>Wang, Z G</creator><creator>Fei, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111208</creationdate><title>Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice</title><author>Sun, R L ; Wang, H Y ; Yang, X Y ; Sheng, Z J ; Li, L M ; Wang, L ; Wang, Z G ; Fei, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-cb850ca9d352e54728c1d85ff96032428bb16534e35fc8a03694c56cffeb1a013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Carrier Proteins - genetics</topic><topic>Computational Biology</topic><topic>Disease Resistance - genetics</topic><topic>Disease Resistance - immunology</topic><topic>Gene Expression Regulation</topic><topic>Gene Knockout Techniques</topic><topic>Heterozygote</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-6 - blood</topic><topic>Lipopolysaccharides</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular Sequence Data</topic><topic>Organ Specificity</topic><topic>Protein Binding</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - genetics</topic><topic>Shock, Septic - immunology</topic><topic>Shock, Septic - pathology</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, R L</creatorcontrib><creatorcontrib>Wang, H Y</creatorcontrib><creatorcontrib>Yang, X Y</creatorcontrib><creatorcontrib>Sheng, Z J</creatorcontrib><creatorcontrib>Li, L M</creatorcontrib><creatorcontrib>Wang, L</creatorcontrib><creatorcontrib>Wang, Z G</creatorcontrib><creatorcontrib>Fei, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genetics and molecular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, R L</au><au>Wang, H Y</au><au>Yang, X Y</au><au>Sheng, Z J</au><au>Li, L M</au><au>Wang, L</au><au>Wang, Z G</au><au>Fei, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice</atitle><jtitle>Genetics and molecular research</jtitle><addtitle>Genet Mol Res</addtitle><date>2011-12-08</date><risdate>2011</risdate><volume>10</volume><issue>4</issue><spage>3712</spage><epage>3721</epage><pages>3712-3721</pages><issn>1676-5680</issn><eissn>1676-5680</eissn><abstract>Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Krüppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan. Three hundred and fifty-five putative target genes were identified, which were enriched into the pathways of immune response according to the pathway analysis. These targets indicated that Zfp191 may function as a mediator of the immune response. This was verified in mice heterozygous for Zfp191 (Zfp191(+/-)) using a lipopolysaccharide (LPS)-induced endotoxic shock model. After LPS injection, Zfp191(+/-) mice produced significantly less IL-1β and IL-6 compared to wild-type mice and were resistant to LPS-induced endotoxic shock. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during LPS-induced endotoxic shock.</abstract><cop>Brazil</cop><pmid>22183946</pmid><doi>10.4238/2011.December.8.6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Base Sequence Binding Sites Carrier Proteins - genetics Computational Biology Disease Resistance - genetics Disease Resistance - immunology Gene Expression Regulation Gene Knockout Techniques Heterozygote Interleukin-1beta - blood Interleukin-6 - blood Lipopolysaccharides Mice Mice, Knockout Molecular Sequence Data Organ Specificity Protein Binding Reverse Transcriptase Polymerase Chain Reaction Shock, Septic - blood Shock, Septic - genetics Shock, Septic - immunology Shock, Septic - pathology Survival Analysis |
| title | Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice |
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