Iron deficiency in Yemeni patients with sickle-cell disease
Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, l...
Gespeichert in:
| Veröffentlicht in: | Eastern Mediterranean health journal 2012-03, Vol.18 (3), p.241-245 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 245 |
|---|---|
| container_issue | 3 |
| container_start_page | 241 |
| container_title | Eastern Mediterranean health journal |
| container_volume | 18 |
| creator | Kassim, A Thabet, S Al-Kabban, M Al-Nihari, K |
| description | Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency. |
| doi_str_mv | 10.26719/2012.18.3.241 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1012745274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1012745274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2081-d5141f5955154a9a7fd49b8cadb6bfb4ab5c46241354fe7b974284be0a91521c3</originalsourceid><addsrcrecordid>eNpdkDtLBDEURoMorq62ljJgYzNjnpMEK1l8LCzYaGEVkkyCWeexTmaQ_fdm3NXC4nIvl8PH4QPgAsEClxzJGwwRLpAoSIEpOgAnqBQ8RyWhh-mGGOaESD4DpzGuIcRCUHwMZhgzTinnJ-B22XdtVjkfbHCt3Wahzd5c49qQbfSQXkPMvsLwnsVgP2qXW1fXWRWi09GdgSOv6-jO93sOXh_uXxZP-er5cbm4W-UWQ4HyiiGKPJOMIUa11NxXVBphdWVK4w3VhllaJnvCqHfcSE6xoMZBLRHDyJI5uN7lbvruc3RxUE2Ik4huXTdGhVIFnLI0Cb36h667sW-T3URBghlmMlHFjrJ9F2PvvNr0odH9NkHqp1Y11aqQUERNYnNwuY8dTeOqP_y3R_INAkRv5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1010325259</pqid></control><display><type>article</type><title>Iron deficiency in Yemeni patients with sickle-cell disease</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Kassim, A ; Thabet, S ; Al-Kabban, M ; Al-Nihari, K</creator><creatorcontrib>Kassim, A ; Thabet, S ; Al-Kabban, M ; Al-Nihari, K</creatorcontrib><description>Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency.</description><identifier>ISSN: 1020-3397</identifier><identifier>EISSN: 1687-1634</identifier><identifier>DOI: 10.26719/2012.18.3.241</identifier><identifier>PMID: 22574477</identifier><language>eng</language><publisher>Egypt: World Health Organization</publisher><subject>Adolescent ; Adult ; Anemia ; Anemia, Iron-Deficiency - blood ; Anemia, Iron-Deficiency - diagnosis ; Anemia, Iron-Deficiency - epidemiology ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - epidemiology ; Blood diseases ; Blood Transfusion - statistics & numerical data ; Blood transfusions ; Bone marrow ; Cellulose acetate ; Child ; Child, Preschool ; Clinical medicine ; Comorbidity ; Disease ; Female ; Humans ; Infant ; Iron ; Male ; Reticulocyte Count ; Yemen ; Young Adult</subject><ispartof>Eastern Mediterranean health journal, 2012-03, Vol.18 (3), p.241-245</ispartof><rights>Copyright World Health Organization Mar 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2081-d5141f5955154a9a7fd49b8cadb6bfb4ab5c46241354fe7b974284be0a91521c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22574477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kassim, A</creatorcontrib><creatorcontrib>Thabet, S</creatorcontrib><creatorcontrib>Al-Kabban, M</creatorcontrib><creatorcontrib>Al-Nihari, K</creatorcontrib><title>Iron deficiency in Yemeni patients with sickle-cell disease</title><title>Eastern Mediterranean health journal</title><addtitle>East Mediterr Health J</addtitle><description>Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia</subject><subject>Anemia, Iron-Deficiency - blood</subject><subject>Anemia, Iron-Deficiency - diagnosis</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - epidemiology</subject><subject>Blood diseases</subject><subject>Blood Transfusion - statistics & numerical data</subject><subject>Blood transfusions</subject><subject>Bone marrow</subject><subject>Cellulose acetate</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical medicine</subject><subject>Comorbidity</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Iron</subject><subject>Male</subject><subject>Reticulocyte Count</subject><subject>Yemen</subject><subject>Young Adult</subject><issn>1020-3397</issn><issn>1687-1634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkDtLBDEURoMorq62ljJgYzNjnpMEK1l8LCzYaGEVkkyCWeexTmaQ_fdm3NXC4nIvl8PH4QPgAsEClxzJGwwRLpAoSIEpOgAnqBQ8RyWhh-mGGOaESD4DpzGuIcRCUHwMZhgzTinnJ-B22XdtVjkfbHCt3Wahzd5c49qQbfSQXkPMvsLwnsVgP2qXW1fXWRWi09GdgSOv6-jO93sOXh_uXxZP-er5cbm4W-UWQ4HyiiGKPJOMIUa11NxXVBphdWVK4w3VhllaJnvCqHfcSE6xoMZBLRHDyJI5uN7lbvruc3RxUE2Ik4huXTdGhVIFnLI0Cb36h667sW-T3URBghlmMlHFjrJ9F2PvvNr0odH9NkHqp1Y11aqQUERNYnNwuY8dTeOqP_y3R_INAkRv5Q</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Kassim, A</creator><creator>Thabet, S</creator><creator>Al-Kabban, M</creator><creator>Al-Nihari, K</creator><general>World Health Organization</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Iron deficiency in Yemeni patients with sickle-cell disease</title><author>Kassim, A ; Thabet, S ; Al-Kabban, M ; Al-Nihari, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2081-d5141f5955154a9a7fd49b8cadb6bfb4ab5c46241354fe7b974284be0a91521c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia</topic><topic>Anemia, Iron-Deficiency - blood</topic><topic>Anemia, Iron-Deficiency - diagnosis</topic><topic>Anemia, Iron-Deficiency - epidemiology</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - epidemiology</topic><topic>Blood diseases</topic><topic>Blood Transfusion - statistics & numerical data</topic><topic>Blood transfusions</topic><topic>Bone marrow</topic><topic>Cellulose acetate</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical medicine</topic><topic>Comorbidity</topic><topic>Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Iron</topic><topic>Male</topic><topic>Reticulocyte Count</topic><topic>Yemen</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kassim, A</creatorcontrib><creatorcontrib>Thabet, S</creatorcontrib><creatorcontrib>Al-Kabban, M</creatorcontrib><creatorcontrib>Al-Nihari, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Eastern Mediterranean health journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kassim, A</au><au>Thabet, S</au><au>Al-Kabban, M</au><au>Al-Nihari, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron deficiency in Yemeni patients with sickle-cell disease</atitle><jtitle>Eastern Mediterranean health journal</jtitle><addtitle>East Mediterr Health J</addtitle><date>2012-03</date><risdate>2012</risdate><volume>18</volume><issue>3</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>1020-3397</issn><eissn>1687-1634</eissn><abstract>Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency.</abstract><cop>Egypt</cop><pub>World Health Organization</pub><pmid>22574477</pmid><doi>10.26719/2012.18.3.241</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1020-3397 |
| ispartof | Eastern Mediterranean health journal, 2012-03, Vol.18 (3), p.241-245 |
| issn | 1020-3397 1687-1634 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1012745274 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - diagnosis Anemia, Iron-Deficiency - epidemiology Anemia, Sickle Cell - blood Anemia, Sickle Cell - epidemiology Blood diseases Blood Transfusion - statistics & numerical data Blood transfusions Bone marrow Cellulose acetate Child Child, Preschool Clinical medicine Comorbidity Disease Female Humans Infant Iron Male Reticulocyte Count Yemen Young Adult |
| title | Iron deficiency in Yemeni patients with sickle-cell disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T03%3A24%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Iron%20deficiency%20in%20Yemeni%20patients%20with%20sickle-cell%20disease&rft.jtitle=Eastern%20Mediterranean%20health%20journal&rft.au=Kassim,%20A&rft.date=2012-03&rft.volume=18&rft.issue=3&rft.spage=241&rft.epage=245&rft.pages=241-245&rft.issn=1020-3397&rft.eissn=1687-1634&rft_id=info:doi/10.26719/2012.18.3.241&rft_dat=%3Cproquest_cross%3E1012745274%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1010325259&rft_id=info:pmid/22574477&rfr_iscdi=true |