N -acetylcysteine (NAC) Protects Against Acute Kidney Injury (AKI) Following Prolonged Pneumoperitoneum in the Rat

Background Acute kidney injury (AKI) following prolonged laparoscopy is a documented phenomenon. Carbon dioxide pneumoperitoneum induces oxidative stress. Previous experimental studies have shown that the antioxidant, N -acetylcysteine, protects the rat from AKI following ischemia-reperfusion. The a...

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Veröffentlicht in:	The Journal of surgical research 2012-06, Vol.175 (2), p.312-315
Hauptverfasser:	Seguro, Antonio Carlos, M.D., Ph.D, Poli de Figueiredo, Luiz F., M.D., Ph.D, Shimizu, Maria Heloisa M., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - therapeutic use Acute Kidney Injury - etiology Acute Kidney Injury - physiopathology Acute Kidney Injury - prevention & control AKI Animals Antioxidants - therapeutic use Carbon Dioxide - administration & dosage glomerular filtration rate Glomerular Filtration Rate - physiology Infusions, Parenteral Inulin - metabolism Kidney - metabolism Kidney - physiopathology Male Models, Animal NAC oxidative stress Oxidative Stress - physiology pneumoperitoneum Pneumoperitoneum - complications Rats Rats, Wistar Reperfusion Injury - complications Surgery Thiobarbituric Acid Reactive Substances - metabolism Time Factors
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