Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release
We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii)...
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| Veröffentlicht in: | Journal of the American Chemical Society 2012-05, Vol.134 (18), p.7656-7659 |
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| container_end_page | 7659 |
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| container_issue | 18 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 134 |
| creator | Jana, Avijit Devi, K. Sanjana P Maiti, Tapas K Singh, N. D. Pradeep |
| description | We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery. |
| doi_str_mv | 10.1021/ja302482k |
| format | Article |
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In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - metabolism</subject><subject>Chlorambucil - administration & dosage</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Delayed-Action Preparations - metabolism</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - metabolism</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Neoplasms - drug therapy</subject><subject>Perylene - chemistry</subject><subject>Perylene - metabolism</subject><subject>Photolysis</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0c1OGzEQB3Croioh7aEvgHxBgoOpP9ZZLzeUlg-JNqil55XjnU0cvHawd0F5mr4qDqGckCxZo_nNXxoNQl8ZPWWUs28rLSgvFL__gEZMckok45M9NKKUclKqidhHBymtcllwxT6hfc4lq2ShRujfLcSNAw9EkI3roF9qH9wZvnBDiJAM-B7P4kJ7a_Cv3Frr2FvjIGGdH_5j_cIBmYZuHfzW3i5Dvx3MZbKP8DJjdIwWIn6y_RL_Bu3Ine0A_wzeZpsTcGjxuc-52pvsvsdhkZ0DneAz-thql-DL6z9Gfy9-3E2vyM3s8np6fkO0YLInhWqU4CCbeVXOKyGhkRUHaqpCtUXZVlI0paCTlnGYKy0bxtlEtJzKqjQSoBJjdLzLXcfwMEDq687m7Z3THsKQakYZ54xSVWZ6sqMmhpQitPU62k7HTUb19h712z2yPXyNHeYdNG_y_wEyONoBbVK9CkP0ect3gp4BrkqT4Q</recordid><startdate>20120509</startdate><enddate>20120509</enddate><creator>Jana, Avijit</creator><creator>Devi, K. 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Soc</addtitle><date>2012-05-09</date><risdate>2012</risdate><volume>134</volume><issue>18</issue><spage>7656</spage><epage>7659</epage><pages>7656-7659</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. 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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Antineoplastic Agents - administration & dosage Biocompatible Materials - chemistry Biocompatible Materials - metabolism Chlorambucil - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - metabolism Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism HeLa Cells Humans Nanoparticles - chemistry Nanoparticles - ultrastructure Neoplasms - drug therapy Perylene - chemistry Perylene - metabolism Photolysis |
| title | Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release |
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