The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma

Lung adenocarcinoma, with increased incidence in the world, exhibits poor prognosis and is usually resistant to conventional chemotherapy due to drug resistance. The enhancer of zeste homologue 2 (EZH2), a histone methyltransferase, plays a key role in tumorigenesis and cancer development through ch...

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Veröffentlicht in:	Oncology reports 2012-07, Vol.28 (1), p.147-154
Hauptverfasser:	Lv, Yijing, Yuan, Cunzhong, Xiao, Xiaoyan, Wang, Xuping, Ji, Xuming, Yu, Huayun, Wu, Zhichun, Zhang, Jidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma of Lung Adult Aged Antineoplastic Agents - pharmacology Apoptosis Biological and medical sciences Cell Cycle Checkpoints Cell Line, Tumor Cell Movement Cell Nucleus - metabolism Cell Proliferation Cisplatin - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm Enhancer of Zeste Homolog 2 Protein Female Gene Expression Gene Knockdown Techniques Humans Lung Neoplasms - metabolism Male Medical sciences Middle Aged Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Pneumology Polycomb Repressive Complex 2 RNA Interference Transcription Factors - genetics Transcription Factors - metabolism Tumors Tumors of the respiratory system and mediastinum
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