Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review)
The placenta is the organ that is responsible for providing the developing fetus with all the nutrients necessary for its growth and is also responsible for removing fetal waste. Placentation is a crucial process that includes angiogenesis. Angiogenesis involves not only the fetal circulation, but a...
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| Veröffentlicht in: | Molecular medicine reports 2012-07, Vol.6 (1), p.23-27 |
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| creator | Gourvas, Victor Dalpa, Efterpi Konstantinidou, Anastasia Vrachnis, Nikolaos Spandidos, Demetrios A Sifakis, Stavros |
| description | The placenta is the organ that is responsible for providing the developing fetus with all the nutrients necessary for its growth and is also responsible for removing fetal waste. Placentation is a crucial process that includes angiogenesis. Angiogenesis involves not only the fetal circulation, but also placental and endometrial vascular changes. In this study, we review the literature regarding any impairment in the angiogenic process in placentas from pregnancies complicated by fetal growth restriction (FGR). Angiogenesis is regulated by a list of factors, also known as growth factors, such as the vascular endothelial growth factor (VEGF), the placental growth factor (PlGF) and the basic fibroblastic growth factor (bFGF), as well as the partial pressure of oxygen in the fetoplacental vessels. Other factors, such as transcriptional factors, also play a pivotal role, controlling the above-mentioned growth factors. Alterations in these pathways have been described in cases of growth-restricted fetuses. In this review, we provide an insight into these processes and identify the most crucial factors involved. |
| doi_str_mv | 10.3892/mmr.2012.898 |
| format | Article |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adaptation Angiogenesis Angiogenesis Inducing Agents - metabolism Blood vessels Cell cycle Endometrium Female Fetal Growth Retardation - metabolism Fetuses Fibroblast growth factor 2 Humans Hypoxia Neovascularization, Physiologic Permeability Placenta Placenta - blood supply Placenta - metabolism Placenta growth factor Pregnancy Stem cells Transcription factors Vascular endothelial growth factor Veins & arteries |
| title | Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review) |
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