The Protective Effect of Curcumin on Ischemia-Reperfusion–Induced Liver Injury
Abstract Objective Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (...
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| Veröffentlicht in: | Transplantation proceedings 2012-05, Vol.44 (4), p.974-977 |
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| description | Abstract Objective Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results The protocol resulted in elevation of blood NO ( P < .001), TNF-α ( P < .001), and MG ( P < .001). sGOT, sGPT, and LDH were elevated significantly ( P < .001), whereas ATP was significantly diminished ( P < .001). Pretreatment with curcumin (25 mg/kg) significantly attenuated the reperfusion liver injury, while the ATP content reversed. In addition, MG, TNF-α, and NO release were attenuated. Conclusions These results indicated that curcumin exerted potent anti-inflammatory effects in I/R-induced liver injury due to its antioxidant effects. |
| doi_str_mv | 10.1016/j.transproceed.2012.01.081 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1011842700</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0041134512001169</els_id><sourcerecordid>1011842700</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-fedb91bf6712906d70ac420c2c70f09acad38ad260587a49e741349cd9e694a53</originalsourceid><addsrcrecordid>eNqNktGK1DAUhoMo7uzqK0gRBG9aT9I0bbwQlnFXBwZcdL0OmfSUTe2kY9IuzJ3v4Bv6JJ5hZlG88ioJ-f5zko_D2EsOBQeu3vTFFG1Iuzg6xLYQwEUBvICGP2IL3tRlLpQoH7MFgOQ5L2V1xs5T6oHOQpZP2ZkQlZIKYMFubu8wu4njhG7y95hddR3tsrHLlnN089aHbAzZKrk73Hqbf8Ydxm5Ofgy_fvxchXZ22GZrSsZsFfo57p-xJ50dEj4_rRfs6_XV7fJjvv70YbW8XOdOqmrKO2w3mm86VXOhQbU1WCcFOOFq6EBbZ9uysa1QUDW1lRprSR_RrtWotLRVecFeH-uShu8zpslsfXI4DDbgOCdDpngjRQ1A6Nsj6uKYUsTO7KLf2rgn6MAp05u_jZqDUQPckFEKvzj1mTdbunuIPigk4NUJsMnZoaNCzqc_XKVlWeqGuPdHDsnKvcdokvMYyJ-PpNy0o_-_97z7p4wbfPDU-RvuMfXjHAN5N9wkypgvhxk4jAAXQEaULn8DEdWwqA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1011842700</pqid></control><display><type>article</type><title>The Protective Effect of Curcumin on Ischemia-Reperfusion–Induced Liver Injury</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lin, C.M ; Lee, J.F ; Chiang, L.L ; Chen, C.F ; Wang, D ; Su, C.L</creator><creatorcontrib>Lin, C.M ; Lee, J.F ; Chiang, L.L ; Chen, C.F ; Wang, D ; Su, C.L</creatorcontrib><description>Abstract Objective Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results The protocol resulted in elevation of blood NO ( P < .001), TNF-α ( P < .001), and MG ( P < .001). sGOT, sGPT, and LDH were elevated significantly ( P < .001), whereas ATP was significantly diminished ( P < .001). Pretreatment with curcumin (25 mg/kg) significantly attenuated the reperfusion liver injury, while the ATP content reversed. In addition, MG, TNF-α, and NO release were attenuated. Conclusions These results indicated that curcumin exerted potent anti-inflammatory effects in I/R-induced liver injury due to its antioxidant effects.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2012.01.081</identifier><identifier>PMID: 22564600</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adenosine Triphosphate - blood ; Alanine Transaminase - blood ; Animals ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biomarkers - blood ; Curcumin - pharmacology ; Cytoprotection ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Inflammation Mediators - blood ; L-Lactate Dehydrogenase - blood ; Liver - blood supply ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver - surgery ; Liver Diseases - blood ; Liver Diseases - etiology ; Liver Diseases - pathology ; Liver Diseases - prevention & control ; Male ; Medical sciences ; Methylguanidine - blood ; Nitric Oxide - blood ; Oxidative Stress - drug effects ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - blood ; Reperfusion Injury - etiology ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Tissue, organ and graft immunology ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Transplantation proceedings, 2012-05, Vol.44 (4), p.974-977</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-fedb91bf6712906d70ac420c2c70f09acad38ad260587a49e741349cd9e694a53</citedby><cites>FETCH-LOGICAL-c465t-fedb91bf6712906d70ac420c2c70f09acad38ad260587a49e741349cd9e694a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2012.01.081$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25943398$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22564600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, C.M</creatorcontrib><creatorcontrib>Lee, J.F</creatorcontrib><creatorcontrib>Chiang, L.L</creatorcontrib><creatorcontrib>Chen, C.F</creatorcontrib><creatorcontrib>Wang, D</creatorcontrib><creatorcontrib>Su, C.L</creatorcontrib><title>The Protective Effect of Curcumin on Ischemia-Reperfusion–Induced Liver Injury</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Objective Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results The protocol resulted in elevation of blood NO ( P < .001), TNF-α ( P < .001), and MG ( P < .001). sGOT, sGPT, and LDH were elevated significantly ( P < .001), whereas ATP was significantly diminished ( P < .001). Pretreatment with curcumin (25 mg/kg) significantly attenuated the reperfusion liver injury, while the ATP content reversed. In addition, MG, TNF-α, and NO release were attenuated. Conclusions These results indicated that curcumin exerted potent anti-inflammatory effects in I/R-induced liver injury due to its antioxidant effects.</description><subject>Adenosine Triphosphate - blood</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Curcumin - pharmacology</subject><subject>Cytoprotection</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Inflammation Mediators - blood</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver - blood supply</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver - surgery</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - pathology</subject><subject>Liver Diseases - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylguanidine - blood</subject><subject>Nitric Oxide - blood</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - blood</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktGK1DAUhoMo7uzqK0gRBG9aT9I0bbwQlnFXBwZcdL0OmfSUTe2kY9IuzJ3v4Bv6JJ5hZlG88ioJ-f5zko_D2EsOBQeu3vTFFG1Iuzg6xLYQwEUBvICGP2IL3tRlLpQoH7MFgOQ5L2V1xs5T6oHOQpZP2ZkQlZIKYMFubu8wu4njhG7y95hddR3tsrHLlnN089aHbAzZKrk73Hqbf8Ydxm5Ofgy_fvxchXZ22GZrSsZsFfo57p-xJ50dEj4_rRfs6_XV7fJjvv70YbW8XOdOqmrKO2w3mm86VXOhQbU1WCcFOOFq6EBbZ9uysa1QUDW1lRprSR_RrtWotLRVecFeH-uShu8zpslsfXI4DDbgOCdDpngjRQ1A6Nsj6uKYUsTO7KLf2rgn6MAp05u_jZqDUQPckFEKvzj1mTdbunuIPigk4NUJsMnZoaNCzqc_XKVlWeqGuPdHDsnKvcdokvMYyJ-PpNy0o_-_97z7p4wbfPDU-RvuMfXjHAN5N9wkypgvhxk4jAAXQEaULn8DEdWwqA</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Lin, C.M</creator><creator>Lee, J.F</creator><creator>Chiang, L.L</creator><creator>Chen, C.F</creator><creator>Wang, D</creator><creator>Su, C.L</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>The Protective Effect of Curcumin on Ischemia-Reperfusion–Induced Liver Injury</title><author>Lin, C.M ; Lee, J.F ; Chiang, L.L ; Chen, C.F ; Wang, D ; Su, C.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-fedb91bf6712906d70ac420c2c70f09acad38ad260587a49e741349cd9e694a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenosine Triphosphate - blood</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Curcumin - pharmacology</topic><topic>Cytoprotection</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Inflammation Mediators - blood</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver - blood supply</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver - surgery</topic><topic>Liver Diseases - blood</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - pathology</topic><topic>Liver Diseases - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylguanidine - blood</topic><topic>Nitric Oxide - blood</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - blood</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, C.M</creatorcontrib><creatorcontrib>Lee, J.F</creatorcontrib><creatorcontrib>Chiang, L.L</creatorcontrib><creatorcontrib>Chen, C.F</creatorcontrib><creatorcontrib>Wang, D</creatorcontrib><creatorcontrib>Su, C.L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, C.M</au><au>Lee, J.F</au><au>Chiang, L.L</au><au>Chen, C.F</au><au>Wang, D</au><au>Su, C.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Protective Effect of Curcumin on Ischemia-Reperfusion–Induced Liver Injury</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>44</volume><issue>4</issue><spage>974</spage><epage>977</epage><pages>974-977</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Objective Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results The protocol resulted in elevation of blood NO ( P < .001), TNF-α ( P < .001), and MG ( P < .001). sGOT, sGPT, and LDH were elevated significantly ( P < .001), whereas ATP was significantly diminished ( P < .001). Pretreatment with curcumin (25 mg/kg) significantly attenuated the reperfusion liver injury, while the ATP content reversed. In addition, MG, TNF-α, and NO release were attenuated. Conclusions These results indicated that curcumin exerted potent anti-inflammatory effects in I/R-induced liver injury due to its antioxidant effects.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22564600</pmid><doi>10.1016/j.transproceed.2012.01.081</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenosine Triphosphate - blood Alanine Transaminase - blood Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Aspartate Aminotransferases - blood Biological and medical sciences Biomarkers - blood Curcumin - pharmacology Cytoprotection Disease Models, Animal Fundamental and applied biological sciences. Psychology Fundamental immunology Inflammation Mediators - blood L-Lactate Dehydrogenase - blood Liver - blood supply Liver - drug effects Liver - metabolism Liver - pathology Liver - surgery Liver Diseases - blood Liver Diseases - etiology Liver Diseases - pathology Liver Diseases - prevention & control Male Medical sciences Methylguanidine - blood Nitric Oxide - blood Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reperfusion Injury - blood Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - prevention & control Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Tissue, organ and graft immunology Tumor Necrosis Factor-alpha - blood |
| title | The Protective Effect of Curcumin on Ischemia-Reperfusion–Induced Liver Injury |
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