Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension
Carotid chemoreceptors provoke an increase in muscle sympathetic nerve activation (MSNA) in response to hypoxia; they are also tonically active during normoxic breathing. The contribution of peripheral chemoreceptors to sympathetic activation in hypertension is incompletely understood. The aim of ou...
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| Veröffentlicht in: | Hypertension research 2012-05, Vol.35 (5), p.487-491 |
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| container_title | Hypertension research |
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| creator | Siński, Maciej Lewandowski, Jacek Przybylski, Jacek Bidiuk, Joanna Abramczyk, Piotr Ciarka, Agnieszka Gaciong, Zbigniew |
| description | Carotid chemoreceptors provoke an increase in muscle sympathetic nerve activation (MSNA) in response to hypoxia; they are also tonically active during normoxic breathing. The contribution of peripheral chemoreceptors to sympathetic activation in hypertension is incompletely understood. The aim of our study was to investigate the effect of chemoreceptor deactivation on sympathetic activity in untreated patients with hypertension. A total of 12 untreated hypertensive males and 11 male controls participated in this randomized, crossover, placebo-controlled study. MSNA, systolic blood pressure(BP), diastolic BP, heart rate (HR), electrocardiogram, hemoglobin oxygen saturation (Sat%) and respiratory movements were measured during repeated 10-min periods of respiration with 100% oxygen or 21% oxygen in a blinded fashion. Compared with controls, hypertensives had higher resting MSNA (38 ± 10 vs. 29 ± 0.9 burst per min, P |
| doi_str_mv | 10.1038/hr.2011.209 |
| format | Article |
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The contribution of peripheral chemoreceptors to sympathetic activation in hypertension is incompletely understood. The aim of our study was to investigate the effect of chemoreceptor deactivation on sympathetic activity in untreated patients with hypertension. A total of 12 untreated hypertensive males and 11 male controls participated in this randomized, crossover, placebo-controlled study. MSNA, systolic blood pressure(BP), diastolic BP, heart rate (HR), electrocardiogram, hemoglobin oxygen saturation (Sat%) and respiratory movements were measured during repeated 10-min periods of respiration with 100% oxygen or 21% oxygen in a blinded fashion. Compared with controls, hypertensives had higher resting MSNA (38 ± 10 vs. 29 ± 0.9 burst per min, P<0.05), systolic BP (150 ± 12 vs. 124 ± 10 mm Hg, P< 0.001) and diastolic BP (92 ± 10 vs. 77 ± 9 mm Hg, P<0.005). Breathing 100% oxygen caused significant decrease in MSNA in hypertensive patients (38 ± 10 vs. 26 ± 8 burst per min and 100 ± 0 vs. 90 ± 10 arbitrary units, P<0.05) and no change in controls (29 ± 9 vs. 27 ± 7 burst per min and 100 ± 0 vs. 96 ± 11 arbitrary units). BP, respiratory frequency and end tidal CO(2) did not change during chemoreceptor deactivation with hyperoxia. HR decreased and Sat% increased in both the study groups. These results confirm the role of tonic chemoreceptor drive in the development of sympathetic overactivity in hypertension.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2011.209</identifier><identifier>PMID: 22158114</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Carotid Body - physiopathology ; Chemoreceptor Cells - physiology ; Cross-Over Studies ; Electrocardiography ; Heart Rate - physiology ; Humans ; Hyperoxia - physiopathology ; Hypertension - physiopathology ; Male ; Middle Aged ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiopathology ; Oxygen - blood ; Sympathetic Nervous System - physiopathology</subject><ispartof>Hypertension research, 2012-05, Vol.35 (5), p.487-491</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-7de2195eb8488b50835bb213c714feca3cec02f5de5166de8519e594dda151e03</citedby><cites>FETCH-LOGICAL-c379t-7de2195eb8488b50835bb213c714feca3cec02f5de5166de8519e594dda151e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22158114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siński, Maciej</creatorcontrib><creatorcontrib>Lewandowski, Jacek</creatorcontrib><creatorcontrib>Przybylski, Jacek</creatorcontrib><creatorcontrib>Bidiuk, Joanna</creatorcontrib><creatorcontrib>Abramczyk, Piotr</creatorcontrib><creatorcontrib>Ciarka, Agnieszka</creatorcontrib><creatorcontrib>Gaciong, Zbigniew</creatorcontrib><title>Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Carotid chemoreceptors provoke an increase in muscle sympathetic nerve activation (MSNA) in response to hypoxia; they are also tonically active during normoxic breathing. The contribution of peripheral chemoreceptors to sympathetic activation in hypertension is incompletely understood. The aim of our study was to investigate the effect of chemoreceptor deactivation on sympathetic activity in untreated patients with hypertension. A total of 12 untreated hypertensive males and 11 male controls participated in this randomized, crossover, placebo-controlled study. MSNA, systolic blood pressure(BP), diastolic BP, heart rate (HR), electrocardiogram, hemoglobin oxygen saturation (Sat%) and respiratory movements were measured during repeated 10-min periods of respiration with 100% oxygen or 21% oxygen in a blinded fashion. Compared with controls, hypertensives had higher resting MSNA (38 ± 10 vs. 29 ± 0.9 burst per min, P<0.05), systolic BP (150 ± 12 vs. 124 ± 10 mm Hg, P< 0.001) and diastolic BP (92 ± 10 vs. 77 ± 9 mm Hg, P<0.005). Breathing 100% oxygen caused significant decrease in MSNA in hypertensive patients (38 ± 10 vs. 26 ± 8 burst per min and 100 ± 0 vs. 90 ± 10 arbitrary units, P<0.05) and no change in controls (29 ± 9 vs. 27 ± 7 burst per min and 100 ± 0 vs. 96 ± 11 arbitrary units). BP, respiratory frequency and end tidal CO(2) did not change during chemoreceptor deactivation with hyperoxia. HR decreased and Sat% increased in both the study groups. These results confirm the role of tonic chemoreceptor drive in the development of sympathetic overactivity in hypertension.</description><subject>Adult</subject><subject>Carotid Body - physiopathology</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Cross-Over Studies</subject><subject>Electrocardiography</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Hyperoxia - physiopathology</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Oxygen - blood</subject><subject>Sympathetic Nervous System - physiopathology</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMoOj5W7iVLQTrmJk0nWYr4AsHNuC5pcksj06YmmYH-ezuMujkX7vk4i4-Qa2BLYELdd3HJGcAc-ogsQJSqKDmUx2TBNFSFrkR1Rs5T-mKMK6nhlJxxDlIBlAuyW4fBW2ps9jufJxpaak0M2TvaBDdR22EfIlocc4iJ2jDk6JttxkRzoLlD6gcb0SR0NE39aOZXngdd9Lt9RzElHLI3G9pNI8aMQ_JhuCQnrdkkvPq9F-Tz-Wn9-Fq8f7y8PT68F1asdC5WDjloiY0qlWokU0I2DQdhV1C2aI2waBlvpUMJVeVQSdAodemcAQnIxAW5PeyOMXxvMeW698niZmMGDNtUwyxOllwqPaN3B9TGkFLEth6j702cZqjei667WO9Fz7Gnb36Ht02P7p_9Myt-AN0pe9E</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Siński, Maciej</creator><creator>Lewandowski, Jacek</creator><creator>Przybylski, Jacek</creator><creator>Bidiuk, Joanna</creator><creator>Abramczyk, Piotr</creator><creator>Ciarka, Agnieszka</creator><creator>Gaciong, Zbigniew</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension</title><author>Siński, Maciej ; Lewandowski, Jacek ; Przybylski, Jacek ; Bidiuk, Joanna ; Abramczyk, Piotr ; Ciarka, Agnieszka ; Gaciong, Zbigniew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-7de2195eb8488b50835bb213c714feca3cec02f5de5166de8519e594dda151e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Carotid Body - physiopathology</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Cross-Over Studies</topic><topic>Electrocardiography</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Hyperoxia - physiopathology</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Oxygen - blood</topic><topic>Sympathetic Nervous System - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siński, Maciej</creatorcontrib><creatorcontrib>Lewandowski, Jacek</creatorcontrib><creatorcontrib>Przybylski, Jacek</creatorcontrib><creatorcontrib>Bidiuk, Joanna</creatorcontrib><creatorcontrib>Abramczyk, Piotr</creatorcontrib><creatorcontrib>Ciarka, Agnieszka</creatorcontrib><creatorcontrib>Gaciong, Zbigniew</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siński, Maciej</au><au>Lewandowski, Jacek</au><au>Przybylski, Jacek</au><au>Bidiuk, Joanna</au><au>Abramczyk, Piotr</au><au>Ciarka, Agnieszka</au><au>Gaciong, Zbigniew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>35</volume><issue>5</issue><spage>487</spage><epage>491</epage><pages>487-491</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Carotid chemoreceptors provoke an increase in muscle sympathetic nerve activation (MSNA) in response to hypoxia; they are also tonically active during normoxic breathing. The contribution of peripheral chemoreceptors to sympathetic activation in hypertension is incompletely understood. The aim of our study was to investigate the effect of chemoreceptor deactivation on sympathetic activity in untreated patients with hypertension. A total of 12 untreated hypertensive males and 11 male controls participated in this randomized, crossover, placebo-controlled study. MSNA, systolic blood pressure(BP), diastolic BP, heart rate (HR), electrocardiogram, hemoglobin oxygen saturation (Sat%) and respiratory movements were measured during repeated 10-min periods of respiration with 100% oxygen or 21% oxygen in a blinded fashion. Compared with controls, hypertensives had higher resting MSNA (38 ± 10 vs. 29 ± 0.9 burst per min, P<0.05), systolic BP (150 ± 12 vs. 124 ± 10 mm Hg, P< 0.001) and diastolic BP (92 ± 10 vs. 77 ± 9 mm Hg, P<0.005). Breathing 100% oxygen caused significant decrease in MSNA in hypertensive patients (38 ± 10 vs. 26 ± 8 burst per min and 100 ± 0 vs. 90 ± 10 arbitrary units, P<0.05) and no change in controls (29 ± 9 vs. 27 ± 7 burst per min and 100 ± 0 vs. 96 ± 11 arbitrary units). BP, respiratory frequency and end tidal CO(2) did not change during chemoreceptor deactivation with hyperoxia. HR decreased and Sat% increased in both the study groups. These results confirm the role of tonic chemoreceptor drive in the development of sympathetic overactivity in hypertension.</abstract><cop>England</cop><pmid>22158114</pmid><doi>10.1038/hr.2011.209</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Carotid Body - physiopathology Chemoreceptor Cells - physiology Cross-Over Studies Electrocardiography Heart Rate - physiology Humans Hyperoxia - physiopathology Hypertension - physiopathology Male Middle Aged Muscle, Skeletal - innervation Muscle, Skeletal - physiopathology Oxygen - blood Sympathetic Nervous System - physiopathology |
| title | Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension |
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