The role of structural information in the discovery of direct thrombin and factor Xa inhibitors

The quest for novel medications to treat thromboembolic disorders such as venous thrombosis, pulmonary embolism and stroke received a boost when the 3D structures of two major players in the blood coagulation cascade were determined in 1989 and 1993. Structure-guided design of inhibitors of thrombin...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2012-05, Vol.33 (5), p.279-288
1. Verfasser:	Nar, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antithrombins - chemistry Blood Coagulation Factor Inhibitors - chemistry Drug Design Factor Xa - chemistry Factor Xa Inhibitors Humans Protein Conformation Prothrombin - antagonists & inhibitors Prothrombin - chemistry Thrombin - antagonists & inhibitors Thrombin - chemistry
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