Iminoheterocycle as a druggable motif: BACE1 inhibitors and beyond

Beta-secretase 1 (BACE1) is a central nervous system (CNS) aspartyl protease required for production of amyloid beta (Aβ) peptides. Brain-penetrant BACE1 inhibitors are central to test the ‘amyloid hypothesis’, which suggests that a reduction of Aβ species in the CNS would halt or even reverse Alzhe...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2012-05, Vol.33 (5), p.233-240
1. Verfasser:	Zhu, Zhaoning
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - chemistry Animals Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - chemistry Drug Design Heterocyclic Compounds - chemistry Humans Protease Inhibitors - chemistry
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