Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region
Abstract Aims We examined the relationship of hypoglycemic symptoms with health-related quality of life and worry about hypoglycemia among type 2 diabetic patients using oral antihyperglycemic agents (AHA) in the Asia-Pacific region. Methods A total of 2257 type 2 diabetic patients with at least 6 m...
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| Veröffentlicht in: | Diabetes research and clinical practice 2012-05, Vol.96 (2), p.141-148 |
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| creator | Sheu, Wayne H.-H Ji, Li-Nong Nitiyanant, Wannee Baik, Sei Hyun Yin, Donald Mavros, Panagiotis Chan, Siew-Pheng |
| description | Abstract Aims We examined the relationship of hypoglycemic symptoms with health-related quality of life and worry about hypoglycemia among type 2 diabetic patients using oral antihyperglycemic agents (AHA) in the Asia-Pacific region. Methods A total of 2257 type 2 diabetic patients with at least 6 months of oral AHA were enrolled in China, Korea, Malaysia, Thailand, and Taiwan. Quality of life was measured with the EuroQol Visual Analog Scale (EQ-VAS) and EuroQol-5 Dimensions questionnaire (EQ-5D), and worry about hypoglycemia with the worry subscale of the Hypoglycemic Fear Survey-II (HFS). Results The mean (SD) age was 58.7 (10.2) years and HbA1c was 7.5% (1.5). The proportion of patients with an HbA1c |
| doi_str_mv | 10.1016/j.diabres.2011.12.027 |
| format | Article |
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Methods A total of 2257 type 2 diabetic patients with at least 6 months of oral AHA were enrolled in China, Korea, Malaysia, Thailand, and Taiwan. Quality of life was measured with the EuroQol Visual Analog Scale (EQ-VAS) and EuroQol-5 Dimensions questionnaire (EQ-5D), and worry about hypoglycemia with the worry subscale of the Hypoglycemic Fear Survey-II (HFS). Results The mean (SD) age was 58.7 (10.2) years and HbA1c was 7.5% (1.5). The proportion of patients with an HbA1c <6.5% and <7% was 24.9% and 41.8%, respectively. Hypoglycemic symptoms in the prior 6 months were reported by 35.8% of patients. Mean scores on the EQ-VAS and the EQ-5D were significantly lower for patients who had hypoglycemic symptoms compared to those who did not (73.6 vs. 76.9, p < 0.001; 0.88 vs. 0.90, p < 0.0001, respectively), whereas mean score on the HFS was significantly higher (12.5 vs. 6.3, p < 0.001). In multivariate models, hypoglycemic symptoms were independently associated with scores on the EQ-5D, EQ-VAS, and HFS (all p ≤ 0.01–0.001). Symptom severity was positively associated with fear of hypoglycemia (all p ≤ 0.001). Conclusion Hypoglycemic symptoms were associated with reduced quality of life and increased patient worry in patients with type 2 diabetes treated with AHA.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2011.12.027</identifier><identifier>PMID: 22265956</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Administration, Oral ; Aged ; Anxiety - etiology ; Anxiety - psychology ; China ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - psychology ; Endocrinology & Metabolism ; Female ; Humans ; Hypoglycemia ; Hypoglycemia - chemically induced ; Hypoglycemia - psychology ; Hypoglycemic Agents - adverse effects ; Korea ; Malaysia ; Male ; Middle Aged ; Quality of Life ; Surveys and Questionnaires ; Taiwan ; Thailand ; Worry</subject><ispartof>Diabetes research and clinical practice, 2012-05, Vol.96 (2), p.141-148</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-ce0e1978d2fc100a3ae400580e73619d6451cc04fc4bb020c678a9a54aa6b5843</citedby><cites>FETCH-LOGICAL-c420t-ce0e1978d2fc100a3ae400580e73619d6451cc04fc4bb020c678a9a54aa6b5843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2011.12.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22265956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheu, Wayne H.-H</creatorcontrib><creatorcontrib>Ji, Li-Nong</creatorcontrib><creatorcontrib>Nitiyanant, Wannee</creatorcontrib><creatorcontrib>Baik, Sei Hyun</creatorcontrib><creatorcontrib>Yin, Donald</creatorcontrib><creatorcontrib>Mavros, Panagiotis</creatorcontrib><creatorcontrib>Chan, Siew-Pheng</creatorcontrib><title>Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Aims We examined the relationship of hypoglycemic symptoms with health-related quality of life and worry about hypoglycemia among type 2 diabetic patients using oral antihyperglycemic agents (AHA) in the Asia-Pacific region. Methods A total of 2257 type 2 diabetic patients with at least 6 months of oral AHA were enrolled in China, Korea, Malaysia, Thailand, and Taiwan. Quality of life was measured with the EuroQol Visual Analog Scale (EQ-VAS) and EuroQol-5 Dimensions questionnaire (EQ-5D), and worry about hypoglycemia with the worry subscale of the Hypoglycemic Fear Survey-II (HFS). Results The mean (SD) age was 58.7 (10.2) years and HbA1c was 7.5% (1.5). The proportion of patients with an HbA1c <6.5% and <7% was 24.9% and 41.8%, respectively. Hypoglycemic symptoms in the prior 6 months were reported by 35.8% of patients. Mean scores on the EQ-VAS and the EQ-5D were significantly lower for patients who had hypoglycemic symptoms compared to those who did not (73.6 vs. 76.9, p < 0.001; 0.88 vs. 0.90, p < 0.0001, respectively), whereas mean score on the HFS was significantly higher (12.5 vs. 6.3, p < 0.001). In multivariate models, hypoglycemic symptoms were independently associated with scores on the EQ-5D, EQ-VAS, and HFS (all p ≤ 0.01–0.001). Symptom severity was positively associated with fear of hypoglycemia (all p ≤ 0.001). Conclusion Hypoglycemic symptoms were associated with reduced quality of life and increased patient worry in patients with type 2 diabetes treated with AHA.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Anxiety - etiology</subject><subject>Anxiety - psychology</subject><subject>China</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - psychology</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - chemically induced</subject><subject>Hypoglycemia - psychology</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Korea</subject><subject>Malaysia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Quality of Life</subject><subject>Surveys and Questionnaires</subject><subject>Taiwan</subject><subject>Thailand</subject><subject>Worry</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEokvhEUA-ckmwnf8XUFVBi1QJJOBsTZzJ7ixOvLWdVnkuXrBOd-mBCyfb8u_7Zjyfk-St4Jngovqwz3qCzqHPJBciEzLjsn6WbERTy7SRsn6ebCLXPO7Pklfe7znnVV6UL5MzKWVVtmW1Sf5cLwe7NYvGkYCRZ-C91QQBe3ZPYcdo0g7Br0fr3MJg6pmx9-jY7QyGwsLswAwNyGC005YdIBBOwR_VYTkgk2xtFQN6FqLXk7V1YKJfoF2k3KkJzWD7qKeJhR2yC0-QfgdNQ7xyuCU7vU5eDGA8vjmt58mvL59_Xl6nN9-uvl5e3KS6kDykGjmKtm56OWjBOeSABedlw7HOK9H2VVEKrXkx6KLruOS6qhtooSwAqq5sivw8eX_0PTh7O6MPaiSv0RiY0M5exRxEmTd1VUa0PKLaWe8dDurgaAS3RGjlKrVXp7zUmpcSUsW8ou7dqcTcjdg_qf4GFIFPRwDjQ-8InfI6zldjTw51UL2l_5b4-I-DNjSRBvMbF_R7O7spTlEJ5aNA_Vg_zfpnRJxZzVuRPwDrPMHo</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Sheu, Wayne H.-H</creator><creator>Ji, Li-Nong</creator><creator>Nitiyanant, Wannee</creator><creator>Baik, Sei Hyun</creator><creator>Yin, Donald</creator><creator>Mavros, Panagiotis</creator><creator>Chan, Siew-Pheng</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region</title><author>Sheu, Wayne H.-H ; Ji, Li-Nong ; Nitiyanant, Wannee ; Baik, Sei Hyun ; Yin, Donald ; Mavros, Panagiotis ; Chan, Siew-Pheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ce0e1978d2fc100a3ae400580e73619d6451cc04fc4bb020c678a9a54aa6b5843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Anxiety - etiology</topic><topic>Anxiety - psychology</topic><topic>China</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - psychology</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - chemically induced</topic><topic>Hypoglycemia - psychology</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Korea</topic><topic>Malaysia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Quality of Life</topic><topic>Surveys and Questionnaires</topic><topic>Taiwan</topic><topic>Thailand</topic><topic>Worry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheu, Wayne H.-H</creatorcontrib><creatorcontrib>Ji, Li-Nong</creatorcontrib><creatorcontrib>Nitiyanant, Wannee</creatorcontrib><creatorcontrib>Baik, Sei Hyun</creatorcontrib><creatorcontrib>Yin, Donald</creatorcontrib><creatorcontrib>Mavros, Panagiotis</creatorcontrib><creatorcontrib>Chan, Siew-Pheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheu, Wayne H.-H</au><au>Ji, Li-Nong</au><au>Nitiyanant, Wannee</au><au>Baik, Sei Hyun</au><au>Yin, Donald</au><au>Mavros, Panagiotis</au><au>Chan, Siew-Pheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>96</volume><issue>2</issue><spage>141</spage><epage>148</epage><pages>141-148</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Aims We examined the relationship of hypoglycemic symptoms with health-related quality of life and worry about hypoglycemia among type 2 diabetic patients using oral antihyperglycemic agents (AHA) in the Asia-Pacific region. Methods A total of 2257 type 2 diabetic patients with at least 6 months of oral AHA were enrolled in China, Korea, Malaysia, Thailand, and Taiwan. Quality of life was measured with the EuroQol Visual Analog Scale (EQ-VAS) and EuroQol-5 Dimensions questionnaire (EQ-5D), and worry about hypoglycemia with the worry subscale of the Hypoglycemic Fear Survey-II (HFS). Results The mean (SD) age was 58.7 (10.2) years and HbA1c was 7.5% (1.5). The proportion of patients with an HbA1c <6.5% and <7% was 24.9% and 41.8%, respectively. Hypoglycemic symptoms in the prior 6 months were reported by 35.8% of patients. Mean scores on the EQ-VAS and the EQ-5D were significantly lower for patients who had hypoglycemic symptoms compared to those who did not (73.6 vs. 76.9, p < 0.001; 0.88 vs. 0.90, p < 0.0001, respectively), whereas mean score on the HFS was significantly higher (12.5 vs. 6.3, p < 0.001). In multivariate models, hypoglycemic symptoms were independently associated with scores on the EQ-5D, EQ-VAS, and HFS (all p ≤ 0.01–0.001). Symptom severity was positively associated with fear of hypoglycemia (all p ≤ 0.001). Conclusion Hypoglycemic symptoms were associated with reduced quality of life and increased patient worry in patients with type 2 diabetes treated with AHA.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22265956</pmid><doi>10.1016/j.diabres.2011.12.027</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral Aged Anxiety - etiology Anxiety - psychology China Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - psychology Endocrinology & Metabolism Female Humans Hypoglycemia Hypoglycemia - chemically induced Hypoglycemia - psychology Hypoglycemic Agents - adverse effects Korea Malaysia Male Middle Aged Quality of Life Surveys and Questionnaires Taiwan Thailand Worry |
| title | Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region |
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