Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma
To investigate the relationship between the expression of leptin, p-mTOR protein and the pathogenesis, development and clinicopathological features in colon carcinoma. The expression of leptin and p-mTOR protein was evaluated by immunohistochemical methods in 40 normal colon mucosas, 40 colon adenom...
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| Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2012-03, Vol.37 (3), p.233-237 |
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| container_title | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban |
| container_volume | 37 |
| creator | Wang, Di Chen, Jian Chen, Hui Duan, Zhi Xu, Qimei Wei, Meiyan Wang, Lianghua Zhong, Meizuo |
| description | To investigate the relationship between the expression of leptin, p-mTOR protein and the pathogenesis, development and clinicopathological features in colon carcinoma.
The expression of leptin and p-mTOR protein was evaluated by immunohistochemical methods in 40 normal colon mucosas, 40 colon adenomatous polyps and 108 cases of colon carcinomas. The relationship between the staining pattern and clinicopathogical features was examined.
The positive rates of detection of leptin in normal colon mucosa, adenomatous polyps and colon carcinomas were 10% (4/40), 27.5% (11/40), and 71.3% (77/108), respectively; with significant differences among the three groups (P |
| doi_str_mv | 10.3969/j.issn.1672-7347.2012.03.004 |
| format | Article |
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The expression of leptin and p-mTOR protein was evaluated by immunohistochemical methods in 40 normal colon mucosas, 40 colon adenomatous polyps and 108 cases of colon carcinomas. The relationship between the staining pattern and clinicopathogical features was examined.
The positive rates of detection of leptin in normal colon mucosa, adenomatous polyps and colon carcinomas were 10% (4/40), 27.5% (11/40), and 71.3% (77/108), respectively; with significant differences among the three groups (P<0.05). The positive rates of p-mTOR protein in the normal colon mucosa, the adenomatous polyps, and the colon carcinomas were 2.5% (1/40), 20% (8/40), and 61.1% (66/108), respectively; with significant differences among the three groups (P<0.05). The expression of leptin and p-mTOR proteins were related to invasive depth, TNM stages, lymph node metastasis,</description><identifier>ISSN: 1672-7347</identifier><identifier>DOI: 10.3969/j.issn.1672-7347.2012.03.004</identifier><identifier>PMID: 22561505</identifier><language>chi</language><publisher>China</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adenomatous Polyps - metabolism ; Adenomatous Polyps - pathology ; Aged ; Colon - metabolism ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Female ; Humans ; Intestinal Mucosa - metabolism ; Leptin - metabolism ; Male ; Middle Aged ; Neoplasm Metastasis ; Phosphorylation ; Prognosis ; TOR Serine-Threonine Kinases - metabolism</subject><ispartof>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2012-03, Vol.37 (3), p.233-237</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22561505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Duan, Zhi</creatorcontrib><creatorcontrib>Xu, Qimei</creatorcontrib><creatorcontrib>Wei, Meiyan</creatorcontrib><creatorcontrib>Wang, Lianghua</creatorcontrib><creatorcontrib>Zhong, Meizuo</creatorcontrib><title>Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma</title><title>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</title><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><description>To investigate the relationship between the expression of leptin, p-mTOR protein and the pathogenesis, development and clinicopathological features in colon carcinoma.
The expression of leptin and p-mTOR protein was evaluated by immunohistochemical methods in 40 normal colon mucosas, 40 colon adenomatous polyps and 108 cases of colon carcinomas. The relationship between the staining pattern and clinicopathogical features was examined.
The positive rates of detection of leptin in normal colon mucosa, adenomatous polyps and colon carcinomas were 10% (4/40), 27.5% (11/40), and 71.3% (77/108), respectively; with significant differences among the three groups (P<0.05). The positive rates of p-mTOR protein in the normal colon mucosa, the adenomatous polyps, and the colon carcinomas were 2.5% (1/40), 20% (8/40), and 61.1% (66/108), respectively; with significant differences among the three groups (P<0.05). The expression of leptin and p-mTOR proteins were related to invasive depth, TNM stages, lymph node metastasis,</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenomatous Polyps - metabolism</subject><subject>Adenomatous Polyps - pathology</subject><subject>Aged</subject><subject>Colon - metabolism</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Leptin - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Phosphorylation</subject><subject>Prognosis</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhH0A0ar0LyAfOHBJsL1-xEdUlYdUqRL0HjmO0xoldogTCf49ERQuO6P5ZvewCN1SkoOW-v499ymFnErFMgVc5YxQlhPICeEXaPmfL9A6JV8RorUGWagrtGBMSCqIWCK7_ewHN_MYcGxw6_rRB2xCjfusO-xff-x4cn7AtvXB29ib8RTbePTWtDj5Y_DNbIN1eF48TZ0J2M58nmawPsTOXKPLxrTJrc-6Qm-P28PmOdvtn142D7usF1JktqglkRKglkrTggArNAXFq8LoGpqCOQacOa4FocCsU4baSrDGVcpyZmCF7n6v9kP8mFway84n69rWBBenVFJCqYCCg5irN-fqVHWuLvvBd2b4Kv_eAt9Vimag</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Wang, Di</creator><creator>Chen, Jian</creator><creator>Chen, Hui</creator><creator>Duan, Zhi</creator><creator>Xu, Qimei</creator><creator>Wei, Meiyan</creator><creator>Wang, Lianghua</creator><creator>Zhong, Meizuo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma</title><author>Wang, Di ; Chen, Jian ; Chen, Hui ; Duan, Zhi ; Xu, Qimei ; Wei, Meiyan ; Wang, Lianghua ; Zhong, Meizuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p565-c8d606633d67918032891374b8a9d3f82e2342e4950132ce7a1cb52feb7c42a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2012</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenomatous Polyps - metabolism</topic><topic>Adenomatous Polyps - pathology</topic><topic>Aged</topic><topic>Colon - metabolism</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Leptin - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Phosphorylation</topic><topic>Prognosis</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Duan, Zhi</creatorcontrib><creatorcontrib>Xu, Qimei</creatorcontrib><creatorcontrib>Wei, Meiyan</creatorcontrib><creatorcontrib>Wang, Lianghua</creatorcontrib><creatorcontrib>Zhong, Meizuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Di</au><au>Chen, Jian</au><au>Chen, Hui</au><au>Duan, Zhi</au><au>Xu, Qimei</au><au>Wei, Meiyan</au><au>Wang, Lianghua</au><au>Zhong, Meizuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><date>2012-03</date><risdate>2012</risdate><volume>37</volume><issue>3</issue><spage>233</spage><epage>237</epage><pages>233-237</pages><issn>1672-7347</issn><abstract>To investigate the relationship between the expression of leptin, p-mTOR protein and the pathogenesis, development and clinicopathological features in colon carcinoma.
The expression of leptin and p-mTOR protein was evaluated by immunohistochemical methods in 40 normal colon mucosas, 40 colon adenomatous polyps and 108 cases of colon carcinomas. The relationship between the staining pattern and clinicopathogical features was examined.
The positive rates of detection of leptin in normal colon mucosa, adenomatous polyps and colon carcinomas were 10% (4/40), 27.5% (11/40), and 71.3% (77/108), respectively; with significant differences among the three groups (P<0.05). The positive rates of p-mTOR protein in the normal colon mucosa, the adenomatous polyps, and the colon carcinomas were 2.5% (1/40), 20% (8/40), and 61.1% (66/108), respectively; with significant differences among the three groups (P<0.05). The expression of leptin and p-mTOR proteins were related to invasive depth, TNM stages, lymph node metastasis,</abstract><cop>China</cop><pmid>22561505</pmid><doi>10.3969/j.issn.1672-7347.2012.03.004</doi><tpages>5</tpages></addata></record> |
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| ispartof | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2012-03, Vol.37 (3), p.233-237 |
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| language | chi |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenomatous Polyps - metabolism Adenomatous Polyps - pathology Aged Colon - metabolism Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Female Humans Intestinal Mucosa - metabolism Leptin - metabolism Male Middle Aged Neoplasm Metastasis Phosphorylation Prognosis TOR Serine-Threonine Kinases - metabolism |
| title | Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma |
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