Advanced microscopy techniques to assess solid-state properties of inhalation medicines
Efficient control and characterisation of the physico-chemical properties of active pharmaceutical ingredients (APIs) and excipients for orally inhaled drug products (OIDPs) are critical to successful product development. Control and reduction of risk require the introduction of a material science b...
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| Veröffentlicht in: | Advanced drug delivery reviews 2012-03, Vol.64 (4), p.369-382 |
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| container_title | Advanced drug delivery reviews |
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| creator | Shur, Jagdeep Price, Robert |
| description | Efficient control and characterisation of the physico-chemical properties of active pharmaceutical ingredients (APIs) and excipients for orally inhaled drug products (OIDPs) are critical to successful product development. Control and reduction of risk require the introduction of a material science based approach to product development and the use of advanced analytical tools in understanding how the solid-state properties of the input materials influence structure and product functionality. The key issues to be addressed, at a microscopic scale, are understanding how the critical quality attributes of input materials influence surface, interfacial and particulate interactions within OIDPs. This review offers an in-depth discussion on the use of advanced microscopy techniques in characterising of the solid-state properties of particulate materials for OIDPs. The review covers the fundamental principles of the techniques, instrumentation types, data interpretation and specific applications in relation to the product development of OIDPs.
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| doi_str_mv | 10.1016/j.addr.2011.11.005 |
| format | Article |
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[Display omitted]</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Atomic force microscopy</subject><subject>Chemical imaging</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Dry powder inhalers</subject><subject>Excipients - chemistry</subject><subject>Humans</subject><subject>Interferometry</subject><subject>Metered dose inhalers</subject><subject>Microscopy</subject><subject>Microscopy - methods</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Raman chemical imaging</subject><subject>Tomography</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAfZo5ddJ9lv8FKKX1DwougtZJNZmrK7WZO00H9vlqpHYSCQeWaY9yHkmkJCgRZ320QoZRMGlCahAPITMqdVyeKK1dkpmQeojjOoP2fkwrktAGVlAedkxhhlAIzNycdS7cUgUUW9ltY4acZD5FFuBv21Qxd5Ewnn0LnImU6r2HnhMRqtGdF6HQDTRnrYiE54bYaoR6WlHtBdkrNWdA6vft4FeX98eFs9x-vXp5fVch3LDMDHpVQgFdYl5FVeYZo1ChuR12mNkIYPlTehlbE2bzClklVpXYkMkCKmJa1ouiC3x73hpOlgz3vtJHadGNDsHA-iKKMFLdKAsiM65XQWWz5a3Qt7CNDEFXzLJ6F8EspDBaFh6OZn_64J4f5Gfg0G4P4IYEi512i5kxono9qi9FwZ_d_-b-Vbh78</recordid><startdate>20120330</startdate><enddate>20120330</enddate><creator>Shur, Jagdeep</creator><creator>Price, Robert</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120330</creationdate><title>Advanced microscopy techniques to assess solid-state properties of inhalation medicines</title><author>Shur, Jagdeep ; Price, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-7cd0cde9705858e34bdeba5939e0358ed5b70542f5be31c28398a40e1ee371813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Atomic force microscopy</topic><topic>Chemical imaging</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Dry powder inhalers</topic><topic>Excipients - chemistry</topic><topic>Humans</topic><topic>Interferometry</topic><topic>Metered dose inhalers</topic><topic>Microscopy</topic><topic>Microscopy - methods</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Raman chemical imaging</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shur, Jagdeep</creatorcontrib><creatorcontrib>Price, Robert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shur, Jagdeep</au><au>Price, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced microscopy techniques to assess solid-state properties of inhalation medicines</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2012-03-30</date><risdate>2012</risdate><volume>64</volume><issue>4</issue><spage>369</spage><epage>382</epage><pages>369-382</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Efficient control and characterisation of the physico-chemical properties of active pharmaceutical ingredients (APIs) and excipients for orally inhaled drug products (OIDPs) are critical to successful product development. 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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2012-03, Vol.64 (4), p.369-382 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Inhalation Animals Atomic force microscopy Chemical imaging Chemistry, Pharmaceutical - methods Dry powder inhalers Excipients - chemistry Humans Interferometry Metered dose inhalers Microscopy Microscopy - methods Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Raman chemical imaging Tomography |
| title | Advanced microscopy techniques to assess solid-state properties of inhalation medicines |
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