The Role of the beta 5- alpha 11 Loop in the Active-Site Dynamics of Acylated Penicillin-Binding Protein A from Mycobacterium tuberculosis

Penicillin-binding protein A (PBPA) is a class B penicillin-binding protein that is important for cell division in Mycobacterium tuberculosis. We have determined a second crystal structure of PBPA in apo form and compared it with an earlier structure of apoenzyme. Significant structural differences...

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Veröffentlicht in:	Journal of molecular biology 2012-05, Vol.418 (5), p.316-330
Hauptverfasser:	Fedarovich, Alena, Nicholas, Robert A, Davies, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Antibiotics Apoenzymes beta -Lactam antibiotics Ceftriaxone Cell division Crystal structure Data processing Fluorescence Imipenem Mycobacterium tuberculosis Penicillin penicillin-binding protein penicillin-binding protein A Tryptophan
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