Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on retinal dopaminergic system in mice

► We examine effects of methamphetamine and MPTP on the retinal dopaminergic system. ► Neither low or high dose of methamphetamine affected dopamine or its metabolites. ► Low-dose MPTP significantly decreased DOPAC and HVA concentration. ► High dose MPTP produced significant depletion of both DA and...

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Veröffentlicht in:	Neuroscience letters 2012-05, Vol.515 (2), p.107-110
Hauptverfasser:	Hamilton, W. Ryan, Trickler, William J., Robinson, Bonnie L., Paule, Merle G., Ali, Syed F.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Acute effects Amine oxidase (flavin-containing) Animals Catechol O-Methyltransferase - metabolism Dopamine Dopamine - metabolism Dopamine Agents - pharmacology Enzymes High-performance liquid chromatography homovanillic acid Homovanillic Acid - metabolism Male Metabolites Methamphetamine Mice Mice, Inbred C57BL Movement disorders MPTP Nervous system Neurodegenerative diseases Neurotoxicity Neurotoxins Neurotoxins - pharmacology Parkinson's disease Retina Retina - drug effects Retina - metabolism Visual system
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