Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial

Summary Background Infection with Clostridium difficile is the primary infective cause of antibiotic-associated diarrhoea. We aimed to compare efficacy and safety of fidaxomicin and vancomycin to treat patients with C difficile infection in Europe, Canada, and the USA. Methods In this multicentre, d...

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Veröffentlicht in:	The Lancet infectious diseases 2012-04, Vol.12 (4), p.281-289
Hauptverfasser:	Cornely, Oliver A, Prof, Crook, Derrick W, Prof, Esposito, Roberto, Prof, Poirier, André, MD, Somero, Michael S, MD, Weiss, Karl, Prof, Sears, Pamela, PhD, Gorbach, Sherwood, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aminoglycosides - therapeutic use Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Clinical trials Clostridium difficile Clostridium difficile - isolation & purification Diarrhea Diarrhea - drug therapy Diarrhea - microbiology Double-Blind Method Enterocolitis, Pseudomembranous - drug therapy Enterocolitis, Pseudomembranous - microbiology Feces - microbiology Female Gastroenterology. Liver. Pancreas. Abdomen Human bacterial diseases Humans Infection Infectious Disease Infectious diseases Kaplan-Meier Estimate Male Medical sciences Middle Aged Other diseases. Semiology Pharmaceuticals Pharmacology. Drug treatments Prospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Toxins Vancomycin Vancomycin - therapeutic use
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